Enhancement of the biological autoluminescence by mito-liposomal gold nanoparticle nanocarriers

Sardarabadi, Hadi; Chafai, Djamel Eddine; Gheybi, Fatemeh; Sasanpour, Pezhman; Rafii-Tabar, Hashem; Cifra, Michal

doi:10.1016/j.jphotobiol.2020.111812

Cited by 10 publications

(5 citation statements)

References 29 publications

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“…This approach is valuable for selectively targeting liposomes to specific tissues or cells, enhancing the selectivity of drug delivery and diagnostics. For example, the formulation of intra-liposomal GNPs functionalized with SPE-PEG (2000)-maleimide-peptide demonstrated efficiency in penetrating mitochondria and Revolutionizing Therapy: Nanomaterials in Liposomes Redefine the Future of Medicinal Drugs DOI: http://dx.doi.org/10.5772/intechopen.1005237 inducing biological autoluminescence, directly impacting the functioning of these organelles [49]. Nanocarriers like this play a fundamental role in biological research, significantly contributing to understanding biochemical and physiological processes.…”

Section: Functionalization Of Liposomesmentioning

confidence: 99%

Revolutionizing Therapy: Nanomaterials in Liposomes Redefine the Future of Medicinal Drugs

M. Oliveira,

M.F. Duarte,

de L. Lins

et al. 2024

Liposomes - A Modern Approach in Research [Working Title]

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Liposomes are microscopic lipid-based vesicles that have emerged as a promising vehicle for transporting therapeutic agents with precision and efficiency. From enhanced drug bioavailability to targeted delivery, combining nanomaterials and liposomes offers a transformative approach to therapeutic interventions. Encapsulating nanomaterials with drugs in liposomes holds immense significance as it enhances precision, efficiency, and targeted delivery, revolutionizing therapeutic interventions in medicine. This chapter delves into the unique properties of nanomaterials encapsulated within liposomes, examining their potential to revolutionize medicine. In addition, it highlights key advancements, challenges, and prospects in this dynamic and rapidly evolving field, providing readers with a comprehensive understanding of the revolutionary impact on the future of medicinal drugs.

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Section: Functionalization Of Liposomesmentioning

confidence: 99%

Revolutionizing Therapy: Nanomaterials in Liposomes Redefine the Future of Medicinal Drugs

M. Oliveira,

M.F. Duarte,

de L. Lins

et al. 2024

Liposomes - A Modern Approach in Research [Working Title]

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“…NPs are suitable for the enhancement of BAL. Sardarabadi et al [ 151 ] designed mito-liposomal gold nanocarriers; holotomography revealed no changes in cell morphology before cell internalization and an increased affinity to the mitochondria, an essential organelle involved in BAL processes, thus helping to increase BAL measurement in U2OS cells. To our knowledge, not many studies report on using AFM and HTM as complementary techniques to monitor the entry, transformation, and final destination of NMs in living cells.…”

Section: Atomic Force and Holotomography Microscopy In Cancer Microbi...mentioning

confidence: 99%

Holotomography and atomic force microscopy: a powerful combination to enhance cancer, microbiology and nanotoxicology research

Medina-Ramirez,

Macias-Diaz,

Masuoka-Ito

et al. 2024

Discover Nano

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Modern imaging strategies are paramount to studying living systems such as cells, bacteria, and fungi and their response to pathogens, toxicants, and nanomaterials (NMs) as modulated by exposure and environmental factors. The need to understand the processes and mechanisms of damage, healing, and cell survivability of living systems continues to motivate the development of alternative imaging strategies. Of particular interest is the use of label-free techniques (microscopy procedures that do not require sample staining) that minimize interference of biological processes by foreign marking substances and reduce intense light exposure and potential photo-toxicity effects. This review focuses on the synergic capabilities of atomic force microscopy (AFM) as a well-developed and robust imaging strategy with demonstrated applications to unravel intimate details in biomedical applications, with the label-free, fast, and enduring Holotomographic Microscopy (HTM) strategy. HTM is a technique that combines holography and tomography using a low intensity continuous illumination laser to investigate (quantitatively and non-invasively) cells, microorganisms, and thin tissue by generating three-dimensional (3D) images and monitoring in real-time inner morphological changes. We first review the operating principles that form the basis for the complementary details provided by these techniques regarding the surface and internal information provided by HTM and AFM, which are essential and complimentary for the development of several biomedical areas studying the interaction mechanisms of NMs with living organisms. First, AFM can provide superb resolution on surface morphology and biomechanical characterization. Second, the quantitative phase capabilities of HTM enable superb modeling and quantification of the volume, surface area, protein content, and mass density of the main components of cells and microorganisms, including the morphology of cells in microbiological systems. These capabilities result from directly quantifying refractive index changes without requiring fluorescent markers or chemicals. As such, HTM is ideal for long-term monitoring of living organisms in conditions close to their natural settings. We present a case-based review of the principal uses of both techniques and their essential contributions to nanomedicine and nanotoxicology (study of the harmful effects of NMs in living organisms), emphasizing cancer and infectious disease control. The synergic impact of the sequential use of these complementary strategies provides a clear drive for adopting these techniques as interdependent fundamental tools. Graphical abstract

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“…NPs are suitable for the enhancement of BAL. Sardarabadi et al, 2020 designed mito-liposomal gold nanocarriers; holotomography revealed no changes in cell morphology before cell internalization and an increased affinity to the mitochondria, an essential organelle involved in BAL processes, thus helping to increase BAL measurement in U2OS cells [121]. To our knowledge, not many studies report on using AFM and HT as complementary techniques to monitor the entry, transformation, and final destination of NMs in living cells.…”

Section: Nanotoxicology and Nanomedicinementioning

confidence: 99%

Holotomography and Atomic Force Microscopy: A Powerful Combination to Enhance Cancer, Microbiology and Nanotoxicology Research

Medina-Ramirez,

Macías-Díaz,

Masuoka

et al. 2023

Preprint

View full text Add to dashboard Cite

Modern imaging strategies are paramount to studying living systems such as cells, bacteria, and fungi and their response to pathogens, toxicants, and nanomaterials as modulated by exposure and environmental factors. The need to understand the processes and mechanisms of damage, healing and cell survivability of living systems continues to motivate the development of alternative imaging strategies. Of particular interest is the use of label-free techniques that minimize interference of biological processes by foreign marking substances and reduce intense light exposure and potential photo-toxicity effects. This review focus on the potential synergic capabilities of atomic force microscopy (AFM) as a well-developed and robust imaging strategy with demonstrated applications to unravel intimate details in biomedical applications, with the label-free, fast, and enduring Holotomographic Microscopy (HT) strategy. We first review the operating principles that form the basis for the complementary details provided by these techniques regarding the surface and internal information provided by HT and AFM is essential and complimentary for the development of several biomedical areas studying the interaction mechanisms of nanomaterials with living organisms. First, AFM can provide superb resolution on surface morphology and biomechanical characterization. Second, the quantitative phase capabilities of HT enable superb modeling and quantification of the volume, surface area, protein content, and mass density of the main components of cells and microorganisms, including morphology of cells in microbiological systems. These capabilities result from directly quantifying refractive index changes without requiring fluorescent markers or chemicals. As such, HT is ideally suited for long-term monitoring of living organisms in conditions close to their natural settings. We present a case-based review of the principal uses of both techniques and their essential contributions to nanomedicine and nanotoxicology, emphasizing cancer and infectious disease control. The synergic impact of the sequential use of these complementary strategies provides a clear drive for adopting these techniques as interdependent fundamental tools.

show abstract

Enhancement of the biological autoluminescence by mito-liposomal gold nanoparticle nanocarriers

Cited by 10 publications

References 29 publications

Revolutionizing Therapy: Nanomaterials in Liposomes Redefine the Future of Medicinal Drugs

Revolutionizing Therapy: Nanomaterials in Liposomes Redefine the Future of Medicinal Drugs

Holotomography and atomic force microscopy: a powerful combination to enhance cancer, microbiology and nanotoxicology research

Holotomography and Atomic Force Microscopy: A Powerful Combination to Enhance Cancer, Microbiology and Nanotoxicology Research

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