Enhancement of the Circulating Antibody Secreting Cell Response in Human Diarrhea by a Human Lactobacillus Strain

Kaila, Minna; Isolauri, Erika; Soppi, Esa; Virtanen, Elina; Laine, Seppo; Arvilommi, Heikki

doi:10.1203/00006450-199208000-00002

Cited by 616 publications

(282 citation statements)

References 18 publications

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“…It is noteworthy that this stimulation was without an inflammatory response, a property essential for the safe use of the strain in clinical or therapeutic applications [9,17,47]. Lactobacillus rhamnosus GG was also able to stimulate local and systemic IgA to rotavirus in children with acute rotavirus infection [32,46].…”

Section: Functional Effects Of Successful Probiotic Strainsmentioning

confidence: 98%

Probiotics in the new millennium

Vaughan

Mollet²

1999

Nahrung

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Beneficial effects on human health by specific probiotic microorganisms such as prevention of gastrointestinal tract infections immune stimulation, and balancing of the intestinal microflora have been established in numerous clinical trials. The successful probiotic strains which are mainly members of Lactobacillus and more recently Bifidobacterium naturally found in the human intestinal tract, have been traditionally incorporated into fermented milk products but have excellent potential for further inclusion in functional foods and health-related products. While the health claims are generally accepted by both scientists and consumers, often the molecular mechanisms underlying the probiotic properties remains controversial. Further progress concerning the molecular basis of probiotic traits will give vital reinforcement to the probiotic concept and is a prerequisite for rational development into further applications. In this review, current research on the genetics of properties of the intestinal lactobacilli that may contribute to the activity and effectiveness of probiotics is described. The potential of molecular biology for future probiotic applications is addressed and a probiotic strains developed by modern biotechnology with advantages for specific consumers is presented.

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Section: Functional Effects Of Successful Probiotic Strainsmentioning

confidence: 98%

Probiotics in the new millennium

Vaughan

Mollet²

1999

Nahrung

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“…Studies have demonstrated that probiotics improve gut function potentially through a number of mechanisms (1,2), including increasing epithelial barrier function (3) and modulation of the immune response (4)(5)(6). There is also evidence that probiotics can prevent colonization of the gut by pathogens.…”

mentioning

confidence: 99%

Lactobacillus rhamnosus GG Inhibits the Toxic Effects of Staphylococcus aureus on Epidermal Keratinocytes

Mohammedsaeed

McBain

Cruickshank

et al. 2014

Appl Environ Microbiol

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Few studies have evaluated the potential benefits of the topical application of probiotic bacteria or material derived from them. We have investigated whether a probiotic bacterium, Lactobacillus rhamnosus GG, can inhibit Staphylococcus aureus infection of human primary keratinocytes in culture. When primary human keratinocytes were exposed to S. aureus, only 25% of the keratinocytes remained viable following 24 h of incubation. However, in the presence of 10 8 CFU/ml of live L. rhamnosus GG, the viability of the infected keratinocytes increased to 57% (P ‫؍‬ 0.01). L. rhamnosus GG lysates and spent culture fluid also provided significant protection to keratinocytes, with 65% (P ‫؍‬ 0.006) and 57% (P ‫؍‬ 0.01) of cells, respectively, being viable following 24 h of incubation. Keratinocyte survival was significantly enhanced regardless of whether the probiotic was applied in the viable form or as cell lysates 2 h before or simultaneously with (P ‫؍‬ 0.005) or 12 h after (P ‫؍‬ 0.01) S. aureus infection. However, spent culture fluid was protective only if added before or simultaneously with S. aureus. With respect to mechanism, both L. rhamnosus GG lysate and spent culture fluid apparently inhibited adherence of S. aureus to keratinocytes by competitive exclusion, but only viable bacteria or the lysate could displace S. aureus (P ‫؍‬ 0.04 and 0.01, respectively). Furthermore, growth of S. aureus was inhibited by either live bacteria or lysate but not spent culture fluid. Together, these data suggest at least two separate activities involved in the protective effects of L. rhamnosus GG against S. aureus, growth inhibition and reduction of bacterial adhesion.

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“…They inhibit potentially pathogenic bacteria, and have various immunomodulating and immunostimulating effects; they promote immune cell proliferation, enhance phagocyte activity, and increase IgA production. All this determines their potential benefits in preventing infection, particularly by intestinal pathogens, as well as bacterial translocation (95)(96)(97).…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Clinical Practice Guideline: Irritable bowel syndrome with constipation and functional constipation in the adult

Mearin¹,

Ciriza²,

Mínguez³

et al. 2016

Rev Esp Enferm Dig

103

151

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In this Clinical Practice Guideline we discuss the diagnostic and therapeutic approach of adult patients with constipation and abdominal complaints at the confluence of the irritable bowel syndrome spectrum and functional constipation. Both conditions are included among the functional bowel disorders, and have a significant personal, healthcare, and social impact, affecting the quality of life of the patients who suffer from them. The first one is the irritable bowel syndrome subtype, where constipation represents the predominant complaint, in association with recurrent abdominal pain, bloating, and abdominal distension. Constipation is characterized by difficulties with or low frequency of bowel movements, often accompanied by straining during defecation or a feeling of incomplete evacuation. Most cases have no underlying medical cause, and are therefore considered as a functional bowel disorder. There are many clinical and pathophysiological similarities between both disorders, and both respond similarly to commonly used drugs, their primary difference being the presence or absence of pain, albeit not in an "all or nothing" manner. Severity depends not only upon bowel symptom intensity but also upon other biopsychosocial factors (association of gastrointestinal and extraintestinal symptoms, grade of involvement, and perception and behavior variants). Functional bowel disorders are diagnosed using the Rome criteria. This Clinical Practice Guideline has been made consistent with the Rome IV criteria, which were published late in May 2016, and discuss alarm criteria, diagnostic tests, and referral criteria between Primary Care and gastroenterology settings. Furthermore, all the available treatment options (exercise, fluid ingestion, diet with soluble fiber-rich foods, fiber supplementation, other dietary components, osmotic or stimulating laxatives, probiotics, antibiotics, spasmolytics, peppermint essence, prucalopride, linaclotide, lubiprostone, biofeedback, antidepressants, psychological therapy, acupuncture, enemas, sacral root neurostimulation, surgery) are discussed, and practical recommendations are made regarding each of them.

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Enhancement of the Circulating Antibody Secreting Cell Response in Human Diarrhea by a Human Lactobacillus Strain

Cited by 616 publications

References 18 publications

Probiotics in the new millennium

Probiotics in the new millennium

Lactobacillus rhamnosus GG Inhibits the Toxic Effects of Staphylococcus aureus on Epidermal Keratinocytes

Clinical Practice Guideline: Irritable bowel syndrome with constipation and functional constipation in the adult

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