Enhancement of the Cytotoxic Effect of Doxorubicin on Tumor Cells Upon Exposure to Atmospheric Cold Plasma

Akopdzhanov, A. G.; Sveshnikova, E. D.; Guseyn-zade, N. G.; Колик, Л. В.; Konchekov, E. M.; Shimanovskiy, N. L.

doi:10.1007/s11094-021-02363-7

Cited by 8 publications

(3 citation statements)

References 4 publications

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“…The interaction of plasma with an object is complex and highly dependent on various factors, such as the plasma's characteristics, the nature of the object's surface, and the specific application or purpose of the plasma treatment. Plasma finds applications in a very wide range of fields (Figure 1), including controlled fusion, environmental remediation [10][11][12][13], surface modification [14,15], modification of petroleum products [16,17], synthesis of micro- [18,19] and nanomaterials [20,21], disinfection [22][23][24], medicine [25][26][27][28][29][30][31][32], agriculture [33][34][35][36], food processing [37,38] etc. When directed towards biological materials, such as cells, tissues, or microorganisms, plasma can induce a range of effects with potential applications: Int.…”

Section: Physical Plasma and Its Effect On Objectsmentioning

confidence: 99%

Advancements in Plasma Agriculture: A Review of Recent Studies

Konchekov,

Gusein-zade,

Burmistrov

et al. 2023

IJMS

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This review is devoted to a topic of high interest in recent times—the use of plasma technologies in agriculture. The increased attention to these studies is primarily due to the demand for the intensification of food production and, at the same time, the request to reduce the use of pesticides. We analyzed publications, focusing on research conducted in the last 3 years, to identify the main achievements of plasma agrotechnologies and key obstacles to their widespread implementation in practice. We considered the main types of plasma sources used in this area, their advantages and limitations, which determine the areas of application. We also considered the use of plasma-activated liquids and the efficiency of their production by various types of plasma sources.

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Section: Physical Plasma and Its Effect On Objectsmentioning

confidence: 99%

Advancements in Plasma Agriculture: A Review of Recent Studies

Konchekov,

Gusein-zade,

Burmistrov

et al. 2023

IJMS

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“…A series of studies using the "CAPKO" plasma source showed that PDD has a dosedependent cytotoxic effect on cancer cells in vitro. At the same time, the antitumor drug doxorubicin enhances this effect, and the antioxidant dihydroquercetin weakens it [36]. The combined effect of PDD and doxorubicin on tumor cells showed an increase in the effectiveness of doxorubicin by 40%.…”

Section: Introductionmentioning

confidence: 97%

Bacterial Decontamination of Water-Containing Objects Using Piezoelectric Direct Discharge Plasma and Plasma Jet

Konchekov,

Gudkova,

Burmistrov

et al. 2024

Biomolecules

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Cold atmospheric plasma has become a widespread tool in bacterial decontamination, harnessing reactive oxygen and nitrogen species to neutralize bacteria on surfaces and in the air. This technology is often employed in healthcare, food processing, water treatment, etc. One of the most energy-efficient and universal methods for creating cold atmospheric plasma is the initiation of a piezoelectric direct discharge. The article presents a study of the bactericidal effect of piezoelectric direct discharge plasma generated using the multifunctional source “CAPKO”. This device allows for the modification of the method of plasma generation “on the fly” by replacing a unit (cap) on the working device. The results of the generation of reactive oxygen and nitrogen species in a buffer solution in the modes of direct discharge in air and a plasma jet with an argon flow are presented. The bactericidal effect of these types of plasma against the bacteria E. coli BL21 (DE3) was studied. The issues of scaling the treatment technique are considered.

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“…The anti-cancer activity of the above solutions was studied on cell cultures and showed different cytotoxic properties [ 13 , 15 , 16 ]. Most of the studies are devoted to plasma treatment of the nutrient medium in which the cells are placed [ 20 , 21 , 22 ] or the nutrient medium in which the cells are already located [ 21 , 23 , 24 , 25 ]. Although the nutrient medium has a complex composition and the most effective cytotoxic effect, it is not prescribed for medical use.…”

Section: Introductionmentioning

confidence: 99%

The Role of Autophagy and Apoptosis in the Combined Action of Plasma-Treated Saline, Doxorubicin, and Medroxyprogesterone Acetate on K562 Myeloid Leukaemia Cells

Pavlik

Gudkova

Razvolyaeva

et al. 2023

IJMS

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The anti-cancer properties of plasma-treated solutions (PTS) and their interaction with drugs are one of the most popular topics in modern plasma medicine. Our research involved comparing the effects of four physiological saline solutions (0.9% NaCl, Ringer’s solution, Hank’s Balanced Salt Solution, Hank’s Balanced Salt Solution with amino acids added in concentrations observed in the human blood) treated with cold atmospheric plasma and studying the combined cytotoxic effect of PTS with doxorubicin and medroxyprogesterone acetate (MPA). Analysis of the effect of the studied agents on the formation of radicals in the incubation medium, the vitality of K562 myeloid leukaemia cells, and the processes of autophagy and apoptosis in them revealed two key findings. The first is that when using PTS and doxorubicin-containing PTS, autophagy is the predominant process in cancer cells. The second is that combining PTS with MPA enhances apoptotic processes. It was hypothesised that while autophagy is stimulated by the accumulation of reactive oxygen species in the cell, apoptosis is stimulated through specific cell progesterone receptors.

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Enhancement of the Cytotoxic Effect of Doxorubicin on Tumor Cells Upon Exposure to Atmospheric Cold Plasma

Cited by 8 publications

References 4 publications

Advancements in Plasma Agriculture: A Review of Recent Studies

Advancements in Plasma Agriculture: A Review of Recent Studies

Bacterial Decontamination of Water-Containing Objects Using Piezoelectric Direct Discharge Plasma and Plasma Jet

The Role of Autophagy and Apoptosis in the Combined Action of Plasma-Treated Saline, Doxorubicin, and Medroxyprogesterone Acetate on K562 Myeloid Leukaemia Cells

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