Enhancement of the neural response during 40 Hz auditory entrainment in closed-eye state in human prefrontal region

Han, Chuanliang; Zhao, Xixi; Li, Meijia; Haihambo, Naem; Teng, Jiayi; Li, Sixiao; Qiu, Jinyi; Feng, Xiaoyang; Gao, Michel

doi:10.1007/s11571-022-09834-x

Cited by 17 publications

(9 citation statements)

References 89 publications

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“…Other EEG studies have also evaluated the efficacy of different sound conditions to induce gamma brain activity. Auditory stimulation at 40 Hz was found to induce the strongest neuronal response in the prefrontal cortex (PFC) using sinusoidal waves as compared to square wave sound [23]. Steady-state scalp EEG recordings also show that 40 Hz binaural click sounds are effective at inducing 40 Hz cerebral activity in widespread cortical regions, and this is associated with memory performance improvements [24][25][26].…”

Section: Feasibility and Optimization Of Gamma Sensory Stimulation Fo...mentioning

confidence: 99%

Audiovisual gamma stimulation for the treatment of neurodegeneration

Blanco‐Duque,

Chan,

Kahn

et al. 2023

J Intern Med

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Alzheimer's disease (AD) is the most common type of neurodegenerative disease and a health challenge with major social and economic consequences. In this review, we discuss the therapeutic potential of gamma stimulation in treating AD and delve into the possible mechanisms responsible for its positive effects. Recent studies reveal that it is feasible and safe to induce 40 Hz brain activity in AD patients through a range of 40 Hz multisensory and noninvasive electrical or magnetic stimulation methods. Although research into the clinical potential of these interventions is still in its nascent stages, these studies suggest that 40 Hz stimulation can yield beneficial effects on brain function, disease pathology, and cognitive function in individuals with AD. Specifically, we discuss studies involving 40 Hz light, auditory, and vibrotactile stimulation, as well as noninvasive techniques such as transcranial alternating current stimulation and transcranial magnetic stimulation. The precise mechanisms underpinning the beneficial effects of gamma stimulation in AD are not yet fully elucidated, but preclinical studies have provided relevant insights. We discuss preclinical evidence related to both neuronal and nonneuronal mechanisms that may be involved, touching upon the relevance of interneurons, neuropeptides, and specific synaptic mechanisms in translating gamma stimulation into widespread neuronal activity within the brain. We also explore the roles of microglia, astrocytes, and the vasculature in mediating the beneficial effects of gamma stimulation on brain function. Lastly, we examine upcoming clinical trials and contemplate the potential future applications of gamma stimulation in the management of neurodegenerative disorders.

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Section: Feasibility and Optimization Of Gamma Sensory Stimulation Fo...mentioning

confidence: 99%

Audiovisual gamma stimulation for the treatment of neurodegeneration

Blanco‐Duque,

Chan,

Kahn

et al. 2023

J Intern Med

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“…Many authoritative researchers at home and abroad have found that different brain regions have varying sensitivity to different frequency band oscillation signals ( Han et al, 2021a , b , c , 2022a , b , c ; Cao et al, 2022 ). EEG is often used to study neuronal activity.…”

Section: Discussionmentioning

confidence: 99%

Research on brain functions related to visual information processing and body coordination function of pilots based on the low-frequency amplitude method

Li²,

Chen³

et al. 2023

Front. Hum. Neurosci.

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ObjectiveResearch on the differences in physiological and psychological mechanisms of practitioners in different occupations is a current hot spot, such as pilots. This study explores the frequency-dependent changes of pilots’ low-frequency amplitudes in the classical frequency band and sub-frequency band between pilots and general occupations. The goal of the current work is to provide objective brain images for the selection and evaluation of outstanding pilots.MethodsTwenty-six pilots and 23 age-, sex-, and education-matched healthy controls were included in this study. Then the mean low-frequency amplitude (mALFF) of the classical frequency band and sub-frequency band was calculated. The two-sample t-test was performed on SPM12 to analyze the differences between the flight group and control group in the classic frequency band. To explore the main effects and the inter-band effects of the mean low-frequency amplitude (mALFF), the mixed design analysis of variance was applied in the sub-frequency bands.ResultsCompared with the control group, left cuneiform lobe and the right cerebellum six area of pilots show significant difference in the classic frequency band. And the main effect results in the sub-frequency bands show that the area with higher mALFF in the flight group is located on the left middle occipital gyrus, the left cuneiform lobe, the right superior occipital gyrus, the right superior gyrus, and the left lateral central lobule. However, the area where the value of mALFF decreased is mainly located on the left rectangular cleft with surrounding cortex and the right dorsolateral superior frontal gyrus. Besides, compared with the slow-4 frequency band, the mALFF of the left middle orbital middle frontal gyrus of the slow-5 frequency band was increased, while the mALFF value of the left putamen, left fusiform gyrus, and right thalamus was decreased. The sensitivity of the slow-5 frequency band and the slow-4 frequency band to the pilots’ different brain areas was also different. Also, the different brain areas in the classic frequency band and the sub-frequency band were significantly correlated with pilots’ flight hours.ConclusionOur findings showed that the left cuneiform brain area and the right cerebellum of pilots changed significantly during resting state. And there was a positive correlation between the mALFF value of those brain area and flight hours. The comparative analysis of sub-frequency bands found that the slow-5 band could elucidate a wider range of different brain regions, providing new ideas for exploring the brain mechanisms of pilots.

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“…Furthermore, given the localization of auditory cortex, sound stimulation might be more effective than light stimulation in entraining gamma oscillations in the temporal lobes. Therefore, a recent study (Han et al, 2022) 2022) investigated if 40 Hz entrainment in healthy participants could be improved by modulating cognitive workload during stimulation sessions. The authors administered 5 min sessions of gamma light flickering to 16 participants via a LED matrix (FND-588XW4SM00BW35, Forge, United Kingdom).…”

Section: Genus In Healthy Humansmentioning

confidence: 99%

“…Furthermore, given the localization of auditory cortex, sound stimulation might be more effective than light stimulation in entraining gamma oscillations in the temporal lobes. Therefore, a recent study ( Han et al, 2022 ) compared different conditions of auditory 40 Hz entrainment (i.e., sounds with sinusoidal or square waves; open-eye and closed-eye states), with EEG recorded before and after stimulation. Forty hertz sinusoidal waves with closed eyes induced the strongest gamma response in the prefrontal regions among all conditions.…”

Section: Genus In Healthy Humansmentioning

confidence: 99%

An update on the use of gamma (multi)sensory stimulation for Alzheimer’s disease treatment

Manippa

Palmisano

Filardi

et al. 2022

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is characterized by reduced fast brain oscillations in the gamma band (γ, > 30 Hz). Several animal studies show that inducing gamma oscillations through (multi)sensory stimulation at 40 Hz has the potential to impact AD-related cognitive decline and neuropathological processes, including amyloid plaques deposition, neurofibrillary tangles formation, and neuronal and synaptic loss. Therefore Gamma Entrainment Using Sensory stimulation (GENUS) is among the most promising approaches for AD patients’ treatment. This review summarizes the evidence on GENUS effectiveness, from animal models to AD patients. Despite the application on human is in its infancy, the available findings suggest its feasibility for the treatment of AD. We discuss such results in light of parameter improvement and possible underlying mechanisms. We finally emphasize the need for further research for its development as a disease-modifying non-pharmacological intervention.

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Enhancement of the neural response during 40 Hz auditory entrainment in closed-eye state in human prefrontal region

Cited by 17 publications

References 89 publications

Audiovisual gamma stimulation for the treatment of neurodegeneration

Audiovisual gamma stimulation for the treatment of neurodegeneration

Research on brain functions related to visual information processing and body coordination function of pilots based on the low-frequency amplitude method

An update on the use of gamma (multi)sensory stimulation for Alzheimer’s disease treatment

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