Cortical inhibition plays an important role in information processing in the brain. However, the mechanisms by which inhibition and excitation are coordinated to generate functions in the six layers of the cortex remain unclear. Here, we measured laminar-specific responses to stimulus orientations in primary visual cortex (V1) of awake monkeys (male, Macaca mulatta ). We distinguished inhibitory effects (suppression) from excitation, by taking advantage of the separability of excitation and inhibition in the orientation and time domains. We found two distinct types of suppression governing different layers. Fast suppression (FS) was strongest in input layers (4C and 6), and slow suppression (SS) was 3 times stronger in output layers (2/3 and 5). Interestingly, the two types of suppression were correlated with different functional properties measured with drifting gratings. FS was primarily correlated with orientation selectivity in input layers ( r = −0.65, p < 10 −9 ), whereas SS was primarily correlated with surround suppression in output layers ( r = 0.61, p < 10 −4 ). The earliest SS in layer 1 indicates the origin of cortical feedback for SS, in contrast to the feedforward/recurrent origin of FS. Our results reveal two V1 laminar subnetworks with different response suppression that may provide a general framework for laminar processing in other sensory cortices. SIGNIFICANCE STATEMENT This study sought to understand inhibitory effects (suppression) and their relationships with functional properties in the six different layers of the cortex. We found that the diversity of neural responses across layers in primary visual cortex (V1) could be fully explained by one excitatory and two suppressive components (fast and slow suppression). The distinct laminar distributions, origins, and functional roles of the two types of suppression provided a simplified representation of the differences between two V1 subnetworks (input network and output network). These results not only help to elucidate computational principles in macaque V1, but also provide a framework for general computation of cortical laminae in other sensory cortices.

Recurrent outbreaks of the coronavirus disease 2019 (COVID-19) have occurred in many countries around the world. We developed a twofold framework in this study, which is composed by one novel descriptive model to depict the recurrent global outbreaks of COVID-19 and one dynamic model to understand the intrinsic mechanisms of recurrent outbreaks. We used publicly available data of cumulative infected cases from 1 January 2020 to 2 January 2021 in 30 provinces in China and 43 other countries around the world for model validation and further analyses. These time series data could be well fitted by the new descriptive model. Through this quantitative approach, we discovered two main mechanisms that strongly correlate with the extent of the recurrent outbreak: the sudden increase in cases imported from overseas and the relaxation of local government epidemic prevention policies. The compartmental dynamical model (Susceptible, Exposed, Infectious, Dead and Recovered (SEIDR) Model) could reproduce the obvious recurrent outbreak of the epidemics and showed that both imported infected cases and the relaxation of government policies have a causal effect on the emergence of a new wave of outbreak, along with variations in the temperature index. Meanwhile, recurrent outbreaks affect consumer confidence and have a significant influence on GDP. These results support the necessity of policies such as travel bans, testing of people upon entry, and consistency of government prevention and control policies in avoiding future waves of epidemics and protecting economy.

Gamma oscillation (GAMMA) in the local field potential (LFP) is a synchronized activity commonly found in many brain regions, and it has been thought as a functional signature of network connectivity in the brain, which plays important roles in information processing. Studies have shown that the response property of GAMMA is related to neural interaction through local recurrent connections (RC), feed-forward (FF), and feedback (FB) connections. However, the relationship between GAMMA and long-range horizontal connections (HC) in the brain remains unclear. Here, we aimed to understand this question in a large-scale network model for the primary visual cortex (V1). We created a computational model composed of multiple excitatory and inhibitory units with biologically plausible connectivity patterns for RC, FF, FB, and HC in V1; then, we quantitated GAMMA in network models at different strength levels of HC and other connection types. Surprisingly, we found that HC and FB, the two types of large-scale connections, play very different roles in generating and modulating GAMMA. While both FB and HC modulate a fast gamma oscillation (around 50-60 Hz) generated by FF and RC, HC generates a new GAMMA oscillating around 30 Hz, whose power and peak frequency can also be modulated by FB. Furthermore, response properties of the two GAMMAs in a network with both HC and FB are different in a way that is highly consistent with a recent experimental finding for distinct GAMMAs in macaque V1. The results suggest that distinct GAMMAs are signatures for neural connections in different spatial scales and they might be related to different functions for information integration. Our study, for the first time, pinpoints the underlying circuits for distinct GAMMAs in a mechanistic model for macaque V1, which might provide a new framework to study multiple gamma oscillations in other cortical regions.