Enhancement of the photokilling effect of aluminum phthalocyanine in photodynamic therapy by conjugating with nitrogen-doped TiO2 nanoparticles

Pan, Xiaobo; Xie, Jin; Li, Zheng; Chen, Maxin; Wang, Mengyan; Wang, Pei-Nan; Chen, Li; Mi, Lan

doi:10.1016/j.colsurfb.2015.04.028

Cited by 46 publications

(30 citation statements)

References 40 publications

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“…However, the problem of tumor delivery still remains, mainly due to their lipophylic character, poor tumor specificity and the Pc tendency to aggregate. A number of possible delivery strategies have been suggested, ranging from the use of oil-in-water (o/w) emulsions to liposomes and nanoparticles as potential carrier vehicles reviewed in Josefson, et al [23, 39, 40, 41, 42, 43, 44] and to enhance the cellular uptake and subsequent antitumor efficacy of PDT [45, 46, 47]. …”

Section: Discussionmentioning

confidence: 99%

Combined regimen of photodynamic therapy mediated by Gallium phthalocyanine chloride and Metformin enhances anti-melanoma efficacy

et al. 2017

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BackgroundMelanoma therapy is challenging, especially in advanced cases, due to multiple developed tumor defense mechanisms. Photodynamic therapy (PDT) might represent an adjuvant treatment, because of its bimodal action: tumor destruction and immune system awakening. In this study, a combination of PDT mediated by a metal substituted phthalocyanine—Gallium phthalocyanine chloride (GaPc) and Metformin was used against melanoma. The study aimed to: (1) find the anti-melanoma efficacy of GaPc-PDT, (2) assess possible beneficial effects of Metformin addition to PDT, (3) uncover some of the mechanisms underlining cell killing and anti-angiogenic effects.MethodsTwo human lightly pigmented melanoma cell lines: WM35 and M1/15 subjected to previous Metformin exposure were treated by GaPc-PDT. Cell viability, death mechanism, cytoskeleton alterations, oxidative damage, were assessed by means of colorimetry, flowcytometry, confocal microscopy, spectrophotometry, ELISA, Western Blotting.ResultsGaPc proved an efficient photosensitizer. Metformin addition enhanced cell killing by mechanisms dependent on the cell line, namely apoptosis in the metastatic M1/15 and necrosis in the radial growth phase, WM35. Cell death mechanism relied on the inhibition of nuclear transcription factor (NF)-κB activation and tumor necrosis factor (TNF)—related apoptosis-inducing ligand (TRAIL) sensitization, leading to TRAIL and TNF-α induced apoptosis. Metformin diminished the anti-angiogenic effect of PDT.ConclusionsMetformin addition to GaPc-PDT increased tumor cell killing through enhanced oxidative damage and induction of proapoptotic mechanisms, but altered PDT anti-angiogenic effects.General significanceCombination of Metformin and PDT might represent a solution to enhance the efficacy, leading to a potential adjuvant role of PDT in melanoma therapy.

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Section: Discussionmentioning

confidence: 99%

Combined regimen of photodynamic therapy mediated by Gallium phthalocyanine chloride and Metformin enhances anti-melanoma efficacy

et al. 2017

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“…The discussed in this chapter selected TiO2 NPs combined with photosensitizers were summarized in Table 1. An excellent example of a combination of TiO2 NPs and phthalocyanine was presented by Pan et al, who linked aluminum(III) tetrasulfonatedphthalocyanine chloride (TSAlClPc) to nitrogen-doped anatase TiO2 NPs by electrostatic interactions (Figure 4) [58]. The hybrid material was characterized by Zeta potential, transmission electron microscopy and UV-Vis absorption spectroscopy.…”

Section: Modifications Of Tio2 With Photosensitizers Aiming To Improvmentioning

confidence: 99%

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

Mlynarczyk

et al. 2020

Preprint

106

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Metallic nanoparticles (NPs), among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in the novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites with other molecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 NPs, leading to hybrid materials. These nanostructures can reveal increased light absorption allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer therapy, many approaches utilizing titanium dioxide were tested. The most significant studies are discussed in this review.

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“…The photokilling efficiency of N–TiO 2 –Pc was over ten times higher than that of Pc. Their results showed that N–TiO 2 –Pc is a promising candidate as a photosensitizer in PDT …”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy and nuclear imaging activities of zinc phthalocyanine‐integrated TiO₂ nanoparticles in breast and cervical tumors

et al. 2017

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In recent years, phthalocyanines (Pcs) have been widely used as photosensitizer in photodynamic therapy applications. Because of their strong absorptions in the near-infrared region (640-700 nm). The integration of phthalocyanine derivatives to a nanoparticle is expected to be efficient way to improve the activity of the photosensitizer on the targeted tissue. It is known that the integrated molecules not only show better accumulation on tumor tissue but also reduce toxicity in healthy tissues. In this study, the ZnPc molecule was synthesized and integrated to the TiO nanoparticle, to investigate the potential of PDT and its cytotoxicity. Additionally, ZnPc and ZnPc-TiO molecules were labeled with I and it was aimed to put forth the nuclear imaging/therapy potentials of I labeled ZnPc/ZnPc-TiO by determining in vitro uptakes in mouse mammary carcinoma (EMT6), human cervical adenocarcinoma (HeLa). In result of our study, it was observed that the radiolabeling yields of the synthesized ZnPc and ZnPc-TiO with I were quite high. In vitro uptake studies shown that I-ZnPc-TiO could be a potential agent for nuclear imaging/treatment of breast and cervical cancers. According to PDT results, ZnPc-TiO might have as to be a potential PDT agent in the treatment of cervical tumor. ZnPc and ZnPc-TiO might be used as theranostic agents.

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Enhancement of the photokilling effect of aluminum phthalocyanine in photodynamic therapy by conjugating with nitrogen-doped TiO2 nanoparticles

Cited by 46 publications

References 40 publications

Combined regimen of photodynamic therapy mediated by Gallium phthalocyanine chloride and Metformin enhances anti-melanoma efficacy

Combined regimen of photodynamic therapy mediated by Gallium phthalocyanine chloride and Metformin enhances anti-melanoma efficacy

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Photodynamic therapy and nuclear imaging activities of zinc phthalocyanine‐integrated TiO₂ nanoparticles in breast and cervical tumors

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Enhancement of the photokilling effect of aluminum phthalocyanine in photodynamic therapy by conjugating with nitrogen-doped TiO2 nanoparticles

Cited by 46 publications

References 40 publications

Combined regimen of photodynamic therapy mediated by Gallium phthalocyanine chloride and Metformin enhances anti-melanoma efficacy

Combined regimen of photodynamic therapy mediated by Gallium phthalocyanine chloride and Metformin enhances anti-melanoma efficacy

Titanium Dioxide Nanoparticles &ndash; Prospects and Applications in Medicine

Photodynamic therapy and nuclear imaging activities of zinc phthalocyanine‐integrated TiO2 nanoparticles in breast and cervical tumors

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Product

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Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Photodynamic therapy and nuclear imaging activities of zinc phthalocyanine‐integrated TiO₂ nanoparticles in breast and cervical tumors