Enhancement of the water solubility and antioxidant activity of hesperidin by chitooligosaccharide

Abstract

The preparation conditions of Hesp-COS in this study were efficient and produced an increment in both the water solubility and antioxidant activity of hesperidin. © 2017 Society of Chemical Industry.

Hesperidin: synthesis and characterization of bioflavonoid complex

“…2 shows also the thermal stability of obtained AMS-HESP complex with a 12.5-15.2% loss of weight (Table1). However, the pure hesperidin has low thermal stability, reported previously by Cao et al They described the loss of weight about 60% between 266 and 500 °C [9]. The results obtained for pure hesperidin are similar to those in literature (Fig.…”

“…Cao et al described preparation and characterization of complex hesperidin and chitooligosaccharide. They reported that obtained product has stronger antioxidant properties than hesperidin [9]. The antioxidant properties of the flavonoid rutin and two derivatives: rutin laurate and rutin palmitate were investigated showing decreased reducing power and metal chelating abilities as compared to rutin [10].…”

Benefits of Hesperidin for Cutaneous Functions

“…Although hesperidin alone barely dissolves in aqueous solution, it dissolves well in both propylene glycol and poly(ethylene glycol)-400 [71]. Reaction of hesperidin with chitooligosaccharide yields hesperidin-chitooligosaccharide complex, which renders it water soluble and further exhibits superior antioxidant activity to hesperidin alone [72]. Moreover, mix of hesperidin and other flavonoids such as theaflavin-3 3′-digallate can increase the solubility of hesperidin in 10% dimethyl sulfoxide [73].…”

Application of Gelatin Decorated with Allura Red as Resonance Rayleigh Scattering Sensor to Detect Chito-Oligosaccharides

“…COS captured much attention from researchers on account of its good dissolvability [2] and a higher degree of deacetylation [3]. To our knowledge, COS has been proven to not only have antioxidant activity [4], and antimicrobial activity [5] but also have anti-tumor activity [6,7] and anti-inflammatory properties [8,9]. Therefore, COS was widely used in many fields, such as cosmeceutical products [10], nutraceuticals [11], pharmaceuticals [3], and core-shell nanoparticles [12].…”

“…Therefore, the development of a simple, rapid, sensitive and accurate quantitative analysis method will greatly improve the quality control level of COS products. 0.2-9.9 mg/L 16 mg/mL ELISA [16] capillary electrophoresis (GlcN)2 2 µmol/L [17] (GlcN)3 2 µmol/L (GlcN) 4 2 µmol/L (GlcN) 5 3 µmol/L (GlcN) 6 5 µmol/L a representing the product of hydrolysis of COS, glucosamine.…”