Enhancement of vascular endothelial growth factor’s angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine

Abbas, Ozan Luay; Terzi, Yunus Kasım; Özatik, Orhan; Özatik, Fikriye Yasemin; Turna, Gamze; Nar, Rukiye; Musmul, Ahmet

doi:10.1080/2000656x.2017.1285784

Cited by 1 publication

(1 citation statement)

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“…In addition, nicotine inhibited the angiogenesis process in wound healing by inhibiting angiogenic factors, where the cells that produced these factors, such as lymphocytes, were reduced by nicotine. Reduced lymphocytes could cause decreased ability to form new blood vessels [18,19].…”

Section: Difference In the Number Of Fibroblasts Between The Exposure And Treatment Groups 3 Resultsmentioning

confidence: 99%

The Effects of Antimicrobial Peptide Gel on Angiogenesis and Fibroblast Cells in Periodontal Tissue Regeneration in a Periodontitis Rats Model Exposed by Nicotine

Andriani¹,

Rahmawati²,

Nurhasanah³

et al. 2021

Advances in Health Sciences Research

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Nicotine, a major component of tobacco, is a significant contributing factor for the exacerbation of periodontal diseases. Periodontitis, one of the periodontal diseases, leads to alveolar bone damage triggered by bacteria and exacerbated by nicotine exposure as mostly suffered by smokers. Periodontitis treatment requires an antibacterial for the regeneration process; antimicrobial peptide gel (AMP) has a broad-spectrum antimicrobial that is rarely resistant. This study aims to determine the effect of antimicrobial peptide gel on the regeneration process of periodontitis in rat models exposed to nicotine by observing the number of angiogenesis and fibroblast cells. Twenty-four Wistar rats were divided into four groups based on nicotine exposure, the control group and treated rats. Periodontitis was induced by ligation on the mandibular central incisor for 14 days, and the periodontitis rats were treated with AMP on their sulcus of gingiva on day 1, 3, and 7. On day 3, 7, and 14 after treatment, two rats were taken randomly in each group for decapitation, followed by histological processing and examination with Hematoxylin-Eosin. The non-parametric statistic test of Kruskal-Wallis revealed that the value of p=0,000 for angiogenesis and p=0,001 for fibroblast showed significant difference (p <0,05 ) between the treated and control groups in both groups with and without exposure to nicotine. Conclusion: The high number of angiogenesis and fibroblast cells in treated rats indicated that the Antimicrobial Peptide Gel successfully accelerated periodontitis' regeneration process in rat models exposed to nicotine.

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Section: Difference In the Number Of Fibroblasts Between The Exposure And Treatment Groups 3 Resultsmentioning

confidence: 99%

The Effects of Antimicrobial Peptide Gel on Angiogenesis and Fibroblast Cells in Periodontal Tissue Regeneration in a Periodontitis Rats Model Exposed by Nicotine

Andriani¹,

Rahmawati²,

Nurhasanah³

et al. 2021

Advances in Health Sciences Research

View full text Add to dashboard Cite

show abstract

Enhancement of vascular endothelial growth factor’s angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine

Abstract: Notch inhibition significantly improved TRAM flap survival in animals exposed to nicotine by promoting VEGF-induced angiogenesis.

Cited by 1 publication

References 48 publications

The Effects of Antimicrobial Peptide Gel on Angiogenesis and Fibroblast Cells in Periodontal Tissue Regeneration in a Periodontitis Rats Model Exposed by Nicotine

The Effects of Antimicrobial Peptide Gel on Angiogenesis and Fibroblast Cells in Periodontal Tissue Regeneration in a Periodontitis Rats Model Exposed by Nicotine

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