Enhancement of water solubility of indomethacin by complexation with protein hydrolysate

Design of chitospheres loaded with pristine polymer particles for extended drug delivery via polyelectrolyte complexation and particulate leaching

“…This may suggest that increasing the quantity of crosslinker and PMMA particles, creates a shift in the release mechanism from a predominantly erosion-based (where n > 1) release towards a coupled polymer-relaxation, erosion and diffusion-oriented release termed as super case II transport (where 0.45 < n <0.89) (Maity and Sa, 2014;Nayak et al, 2014). Since indomethacin is a poorly water soluble drug (Inada et al, 2013), its release may occur mainly by surface erosion (Contreras et al, 2012) of the chitospheres as depicted in the SEM images in Fig. 2 in addition to diffusion occurring from the peripherally hydrated layers of the chitospheres and via the porous surface left by the dissolution of surface pristine PMMA particles and erosion of the PEC.…”

Evaluation of the Hydrophilic and Hydrophobic Balance for the Complex between Indomethacin and Casein Hydrolysate Using an Aqueous Two-Phase System

“…Experimental details -72 -for the preparation of Pep are given in the literature [10]. From the results of gel filtration chromatography/HPLC analysis, Pep showed a wide molecular weight distribution with a range of roughly 1,000-10,000 [Da].…”

“…The water solubility of Indo-Pep increases with increasing pH because of the deprotonation of the carboxylic acid group [10]. In order to study the factors for the complexation between indomethacin and Pep, the distribution of Pep and Indo-Pep as a function of pH was examined.…”

“…Recently, complexation with a peptide mixture obtained as casein hydrolysate (Pep) was developed as a novel technique for the enhancement of the water-solubility of indomethacin [10]. The water-solubility of the complex (Indo-Pep) is much higher than that of indomethacin alone.…”

Gamma/alpha‐zein hydrolysates as oral delivery vehicles: Enhanced physicochemical stability and in vitro bioaccessibility of curcumin

“…Recently, some protein fragments and hydrolysates have been studied as delivery systems to improve the physicochemical stability and bioaccessibility of such bioactive ingredients. For example, casein hydrolysate complex remarkably enhances the water solubility of indomethacin (Inada et al ., ), and mungbean protein hydrolysate shows an increase in the efficacy of pentacyclic triterpene anticancer asiatic acid (Wongekalak et al ., ).…”