Enhancing digestive fistula healing by the off-label use of a thermoresponsive vessel occluder polymer associated with esophageal stent placement: A case report

Abstract

are co-founders and shareholder of Evora Biosciences. The other authors declare no financial conflict of interest.Informed patient consent was obtained for publication of patient information.

Local administration of stem cell-derived extracellular vesicles in a thermoresponsive hydrogel promotes a pro-healing effect in a rat model of colo-cutaneous post-surgical fistula

“…It was well-tolerated by the patient while inducing a reduction in the external fistula orifice diameter and secretion output volume in combination to a stent placement. 63 Due to its thermoresponsive properties, this biomaterial can be administrated as a liquid via a catheter. Its gelation in situ at body temperature is expected to enable its retention at the fistula tract, limiting the circulation of secretions and thus favoring the healing process.…”

Regenerative medicine for digestive fistulae therapy: Benefits, challenges and promises of stem/stromal cells and emergent perspectives via their extracellular vesicles

“…Emerging therapies for persisting fistulae tend to advocate minimally invasive treatments through endoscopic placement of stents, through-the-scope or over-the-scope clips [89], or the use of various sealing agents such as fibrin glue [90], cyanoacrylic glue [91] or the thermoresponsive hydrogel poloxamer 407 [92]. Amongst them, the possibility of stem/stromal cell therapy has received growing attention over the years.…”