Enhancing electrospun scaffolds of PVP with polypyrrole/iodine for tissue engineering of skin regeneration by coating via a plasma process

Román-Doval, R.; Tellez-Cruz, M.M.; Rojas-Chávez, H.; Cruz-Martínez, H.; Torres, Gustavo; Vásquez-Garzón, Verónica Rocío

doi:10.1007/s10853-018-3024-7

Cited by 25 publications

(20 citation statements)

References 42 publications

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“…The electrospun scaffolds have been recently proposed to create artificial skin tissue for the dermal replacement as well as to promote the wound healing process. The results obtained by Román-Doval et al [99] from the migration assay proved that electrospun PVP fibers favored the cell viability compared to the electrosprayed PVP particles (mean size of 1.0 ± 1.6 µm). Both morphologies were coated with polypyrrole/iodine, which assisted the cell adhesion and accelerated the wound healing, without damaging the cells.…”

Section: Fibersmentioning

confidence: 92%

“…Furthermore, the in vivo wound healing tests revealed that the emodin-loaded fibers accelerated the wound healing process by about 15 days. In the field of the regenerative medicine, Román-Doval et al [99] produced scaffolds based on electrospun PVP fibers (average diameter of 135.6 ± 1.4 nm). The electrospun scaffolds have been recently proposed to create artificial skin tissue for the dermal replacement as well as to promote the wound healing process.…”

Section: Fibersmentioning

confidence: 99%

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The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

2020

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Polyvinylpyrrolidone (PVP) is a hydrophilic polymer widely employed as a carrier in the pharmaceutical, biomedical, and nutraceutical fields. Up to now, several PVP-based systems have been developed to deliver different active principles, of both natural and synthetic origin. Various formulations and morphologies have been proposed using PVP, including microparticles and nanoparticles, fibers, hydrogels, tablets, and films. Its versatility and peculiar properties make PVP one of the most suitable and promising polymers for the development of new pharmaceutical forms. This review highlights the role of PVP in drug delivery, focusing on the different morphologies proposed for different polymer/active compound formulations. It also provides detailed information on active principles and used technologies, optimized process parameters, advantages, disadvantages, and final applications.

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Section: Fibersmentioning

confidence: 92%

Section: Fibersmentioning

confidence: 99%

The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

2020

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“…Other important active compounds in the healing of a wound are vitamins A, C, and E, zinc, iodine, silver nanoparticles, and copper minerals. Therefore, in many studies, there was a growing tendency to incorporate growth factors or antibacterial molecules into the electrospun materials for enhancing the healing quality of wounds [68,69,70,71,72].…”

Section: Electrospun Scaffolds For Wound Dressing Applicationmentioning

confidence: 99%

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

et al. 2019

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Electrospinning technologies have been applied in the field of tissue engineering as materials, with nanoscale-structures and high porosity, can be easily prepared via this method to bio-mimic the natural extracellular matrix (ECM). Tissue engineering aims to fabricate functional biomaterials for the repairment and regeneration of defective tissue. In addition to the structural simulation for accelerating the repair process and achieving a high-quality regeneration, the combination of biomaterials and bioactive molecules is required for an ideal tissue-engineering scaffold. Due to the diversity in materials and method selection for electrospinning, a great flexibility in drug delivery systems can be achieved. Various drugs including antibiotic agents, vitamins, peptides, and proteins can be incorporated into electrospun scaffolds using different electrospinning techniques and drug-loading methods. This is a review of recent research on electrospun nanofibrous scaffolds for tissue-engineering applications, the development of preparation methods, and the delivery of various bioactive molecules. These studies are based on the fabrication of electrospun biomaterials for the repair of blood vessels, nerve tissues, cartilage, bone defects, and the treatment of aneurysms and skin wounds, as well as their applications related to oral mucosa and dental fields. In these studies, due to the optimal selection of drugs and loading methods based on electrospinning, in vitro and in vivo experiments demonstrated that these scaffolds exhibited desirable effects for the repair and treatment of damaged tissue and, thus, have excellent potential for clinical application.

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“…Proliferation of keratinocytes depends on the degree of cell differentiation, availability of growth factors, and cell attachment to the substrate [9]. Specific designs by polymer processing technologies in combination with surface coating and chemical modification enable the interaction of medical devices with tissue to create a structural microenvironment for cells during scaffold seeding and tissue formation [10,11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Silk Fibroin on Cell Viability in Electrospun Scaffolds of Polyethylene Oxide

et al. 2019

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In this study, a coating from electrospun silk fibroin was performed with the aim to modify the surface of breast implants. We evaluated the effect of fibroin on polymeric matrices of poly (ethylene oxide) (PEO) to enhance cell viability, adhesion, and proliferation of HaCaT human keratinocytes to enhance the healing process on breast prosthesis implantation. We electrospun six blends of fibroin and PEO at different concentrations. These scaffolds were characterized by scanning electron microscopy, contact angle measurements, ATR-FTIR spectroscopy, and X-ray diffraction. We obtained diverse network conformations at different combinations to examine the regulation of cell adhesion and proliferation by modifying the microstructure of the matrix to be applied as a potential scaffold for coating breast implants. The key contribution of this work is the solution it provides to enhance the healing process on prosthesis implantation considering that the use of these PEO–fibroin scaffolds reduced (p < 0.05) the amount of pyknotic nuclei. Therefore, viability of HaCaT human keratinocytes on PEO–fibroin matrices was significantly improved (p < 0.001). These findings provide a rational strategy to coat breast implants improving biocompatibility.

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Enhancing electrospun scaffolds of PVP with polypyrrole/iodine for tissue engineering of skin regeneration by coating via a plasma process

Cited by 25 publications

References 42 publications

The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

Effect of Silk Fibroin on Cell Viability in Electrospun Scaffolds of Polyethylene Oxide

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