Enhancing encapsulation efficiency of food-grade double emulsions containing resveratrol or vitamin B12 by membrane emulsification

Matos, María; Gutiérrez, Gemma; Iglesias, O.; Coca, José; Pazos, Carmen

doi:10.1016/j.jfoodeng.2015.06.002

Cited by 91 publications

(63 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[56][57][58] It is noteworthy that the incorporation of Res decreased the consistency index (k) of all formulations, which demonstrated that this drug affected molecular bonds between formulation components, resulting in a decrease in viscosity. Matos et al 59 reported that emulsions containing Res exhibited viscosities slightly lower than that of the Res-unloaded emulsion. Fujimura et al 52 also observed that Res incorporation decreased the viscosity of an LCS containing silicone glycol copolymer as a surfactant, polyether-functional siloxane as an oily phase, and Carbopol 974P dispersion as an aqueous phase.…”

Section: Continuous Shear (Flow) Rheologymentioning

confidence: 99%

Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity

Fonseca-Santos

Satake

Calixto

et al. 2017

IJN

View full text Add to dashboard Cite

Resveratrol (Res) is a common phytoalexin present in a few edible materials, such as grape skin, peanuts, and red wine. Evidence has shown the beneficial effects of Res on human health, which may be attributed to its anti-inflammatory activity. However, the poor aqueous solubility of Res limits its therapeutic effectiveness. Therefore, the use of nanostructured delivery systems for Res, such as liquid-crystalline systems, could be beneficial. In this study, we aimed to develop, characterize, and determine the in vivo effectiveness of Res-loaded liquid-crystalline systems. Systems containing copaiba balsam oil, polyethylene glycol-40 hydrogenated castor oil, and water were designed. Results of polarized light microscopy, small-angle X-ray scattering, texture-profile analysis, and flow-rheology analysis showed that the Res-loaded liquid-crystalline system had a lamellar structure, textural and mechanical (hardness, compressibility, and adhesiveness) properties, and behaved as a non-Newtonian fluid, showing pseudoplastic behavior upon skin application. Furthermore, all liquid-crystalline systems presented bioadhesive properties that may have assisted in maintaining the anti-inflammatory activity of Res, since the topical application of the Res-loaded lamellar mesophase liquid crystals resulted in edema inhibition in a carrageenan-induced paw-inflammation mouse model. Therefore, Res-loaded lamellar mesophases represent a promising new therapeutic approach for inhibition of skin inflammation.

show abstract

Section: Continuous Shear (Flow) Rheologymentioning

confidence: 99%

Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity

Fonseca-Santos

Satake

Calixto

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…In a recent work, Matos and co‐workers reported the preparation of concentrated W/O/W double emulsions to entrap RSV using a conventional two‐step mechanical emulsification process . The compositions of these double emulsions were the same to the previously reported by the same authors . Regarding the physicochemical characterization, the formulations presented a bimodal and highly polydisperse droplet size distribution with a mean peak in the 10–30 μm range.…”

Section: Delivery Systemsmentioning

confidence: 61%

Recent Strategies in Resveratrol Delivery Systems

2019

View full text Add to dashboard Cite

Resveratrol, a natural polyphenolic stilbenoid widely found in grapes and wines, displays beneficial properties such as cardio‐protective, antioxidant and anti‐inflammatory activities. Trans‐resveratrol (RSV) is the most bioactive and more abundant stereoisomer found in nature. Despite the positive properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chemical instability. During the last years, an increasing number of strategies such as nano and micro encapsulation have been developed in order to overcome these limitations and enhance the use of RSV in nutritional and pharmaceutical applications. This Review summarizes the advances and main properties of several RSV carriers and delivery systems reported during the last 5 years.

show abstract

“…The authors argue that the first peak could represent the excess of emulsifier that is free or present as small aggregates in the continuous phase. The formation of reverse micelles in the oil phase has been described by other authors . We calculated that PGPR was most likely present in large excess (83.7% to 93.7%) for all tested concentrations (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Among the plethora of food‐compatible encapsulation systems, water‐in‐oil‐in‐water (W 1 /O/W 2 ) double emulsions are suitable to encapsulate water‐soluble compounds . Double emulsions combine a high encapsulation efficiency potential with the ability to mask undesirable tastes in a simple, low‐cost method . Only a few studies have focused on encapsulating iron within water‐in‐oil (W/O) emulsions and within double emulsions .…”

Section: Introductionmentioning

confidence: 99%

Double emulsions for iron encapsulation: is a high concentration of lipophilic emulsifier ideal for physical and chemical stability?

2019

View full text Add to dashboard Cite

BACKGROUND Worldwide iron deficiency in diets has led to a growing interest in the development of food‐compatible encapsulation systems for soluble iron, which are able to prevent iron's undesirable off‐taste and pro‐oxidant activity. Here, we explore the use of double emulsions for this purpose, and in particular, how the lipophilic emulsifier (polyglycerol polyricinoleate, PGPR) concentration influences the physicochemical stability of water‐in‐oil‐in‐water (W 1 /O/W 2 ) double emulsions containing ferrous sulphate in the inner water droplets. Double emulsions were prepared with sunflower oil containing 10 to 70 g kg −1 PGPR in the oil phase, and were monitored for droplet size distribution, morphology, encapsulation efficiency (EE) and oxidative stability over time. RESULTS Fresh double emulsions showed an initial EE higher than 88%, but EE decreased upon storage, which occurred particularly fast and to a high extent in the emulsions prepared with low PGPR concentrations. All double emulsions underwent lipid oxidation, in particular those with the highest PGPR concentration, which could be due to the small inner droplet size and thus promoted contact between oil and the internal water phase. CONCLUSION These results show that a too high PGPR concentration is not needed, and sometimes even adverse, when developing double emulsions as iron encapsulation systems. © 2019 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

show abstract

Enhancing encapsulation efficiency of food-grade double emulsions containing resveratrol or vitamin B12 by membrane emulsification

Cited by 91 publications

References 50 publications

Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity

Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity

Recent Strategies in Resveratrol Delivery Systems

Double emulsions for iron encapsulation: is a high concentration of lipophilic emulsifier ideal for physical and chemical stability?

Contact Info

Product

Resources

About