Enhancing extraction ability by rational design of phosphoryl functionalized ionic liquids and mechanistic investigation on neodymium (III) extraction

Wang, Junping; Zhao, Jie-Ying; Feng, Dan; Kang, Xinchun; Sun, Yue; Zhao, Lingling; Liang, Hongze

doi:10.1016/s1002-0721(14)60579-2

Cited by 26 publications

(5 citation statements)

References 34 publications

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“…In recent years, we have synthesized a series of phosphonate- or phosphine oxide-functionalized ILs (PFILs), and explored their potential applications in rare earth extraction, solar energy, and lithium-ion batteries. − These types of ILs exhibit sufficient binding capability to a set of metal ions including lithium and rare earth ions. The intrinsic ionic nature and affinity to metals of PFILs trigger our curiosity to further explore the applicability of PFIL-modified materials as new adsorbents to the selective enrichment of phosphorylated peptides.…”

Section: Results and Discussionmentioning

confidence: 99%

Phosphonate-Functionalized Ionic Liquid: A New Surface Modifier Contributing to the Enhanced Enrichment of Phosphorylated Peptides

Wang

Liang

et al. 2021

ACS Sustainable Chem. Eng.

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Phosphopeptide enrichment with high selectivity and detection sensitivity is essential for phosphoproteomic studies and remains a long-standing challenge. In this study, new immobilized metal affinity chromatography nanocomposite adsorbents with a phosphonate-functionalized ionic liquid (PFIL) as a surface modifier are successfully prepared via a reaction sequence of amination, quaternization, phosphonate hydrolyzation, and metal immobilization. Taking advantages of integrated features of a flexible and strong tripodal phosphonate chelator, a hydrophilic ionic liquid linker, a large surface area, and the size-exclusion effect, the resulting nanocomposite G@mSiO 2 -PFIL-Ti 4+ exhibits excellent detection sensitivity to enrich phosphorylated peptides from a tryptic β-casein digest (0.15 fmol), and superior enrichment selectivity to capture phosphorylated peptides from a digest mixture of β-casein and bovine serum albumin (a molar ratio of 1:10,000). Strong immobilization of tripodal chelation to metal ions endows the nanocomposite adsorbent with high tolerance to experimental conditions, and thus excellent reusability of the adsorbent has been achieved without remarkable loss of enrichment efficiency for 10 cycles. Due to the excellent size-exclusion effect, high enrichment specificity of G@mSiO 2 -PFIL-Ti 4+ to phosphopeptides has been observed and 23 endogenous phosphopeptides have been captured from human saliva. In addition, 924 phosphopeptides (enrichment specificity, 56.1%) have been identified from the tryptic digest of mouse brain lysate. Particularly, six of 975 phosphorylation sites were Alzheimer's disease-related hyperphosphorylation sites within tau protein. These results demonstrate that G@mSiO 2 -PFIL-Ti 4+ nanocomposite affinity materials show great application potential for a proteomic study of complicated biological samples.

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Section: Results and Discussionmentioning

confidence: 99%

Phosphonate-Functionalized Ionic Liquid: A New Surface Modifier Contributing to the Enhanced Enrichment of Phosphorylated Peptides

Wang

Liang

et al. 2021

ACS Sustainable Chem. Eng.

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“…With this aim, ionic liquids have been successfully employed as an organic phase in solvent extraction for the purication of metal ions, including transition metals and rare-earth elements. [10][11][12][25][26][27][28][29][30][31][32] In contrast, less effort has been made in order to replace the aqueous phase by other liquid media able to facilitate the separation process. Deep-eutectic solvents (DESs) could act as a new functionalized, more polar phase for the leaching, solvent extraction, separation and purication of metal ions.…”

Section: Introductionmentioning

confidence: 99%

Separation of rare earths and other valuable metals from deep-eutectic solvents: a new alternative for the recycling of used NdFeB magnets

et al. 2017

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“…Moreover, there are also some studies for the separation of neodymium by solvent extraction using ionic liquids. Wang et al (2016). ILs extraction behaviour was tested under many variables and a solvating mechanism was proposed for Nd(NO 3 ) 3 extraction.…”

Section: Introductionmentioning

confidence: 99%

Experimental and modelling studies of neodymium solvent extraction from chloride media with methyl-tri(octyl/decyl)ammonium oleate ionic liquid diluted in kerosene

et al. 2017

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A study of the solvent extraction process of Nd(III) from chloride solutions has been carried out using an ionic liquid (AliOle) prepared from Aliquat 336 (Methyl-tri(octyl/decyl)ammonium chloride) and Oleic Acid. The IL was chosen among other homemade ionic liquids and commercial extractants due to its high Nd(III) extraction ability and good phase separation. Increasing AliOle concentration improves the extraction of Nd(III) as expected. The pH of the aqueous phase strongly influences the extraction process. The appropriate equilibrium pH region has been established in the range 5–6.5. The effect of chloride concentration in the aqueous phase has been investigated. High concentrations of Cl- anion contribute to increasing the extraction yield by promoting neodymium(III) speciation in the aqueous phase. Two extraction models are proposed from experimental data. Chloride concentration in the aqueous phase determines the Nd(III) extraction mechanism. The models consider extraction of Nd3 + species when chloride concentration in the solution is low and NdCl2 + species when chloride concentration is high. Competitive extraction between HCl and the metal ions is also included in the models. They are able to reproduce feasibly the experimental Nd(III) extraction extension.Peer ReviewedPreprin

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Enhancing extraction ability by rational design of phosphoryl functionalized ionic liquids and mechanistic investigation on neodymium (III) extraction

Cited by 26 publications

References 34 publications

Phosphonate-Functionalized Ionic Liquid: A New Surface Modifier Contributing to the Enhanced Enrichment of Phosphorylated Peptides

Phosphonate-Functionalized Ionic Liquid: A New Surface Modifier Contributing to the Enhanced Enrichment of Phosphorylated Peptides

Separation of rare earths and other valuable metals from deep-eutectic solvents: a new alternative for the recycling of used NdFeB magnets

Experimental and modelling studies of neodymium solvent extraction from chloride media with methyl-tri(octyl/decyl)ammonium oleate ionic liquid diluted in kerosene

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