Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline‐deficient diet: a follow‐up report on long‐term effects of oxidative stress in non‐alcoholic fatty liver disease

Yamamoto, H; Kanno, Keishi; Ikuta, Takuya; Arihiro, Koji; Sugiyama, Akiko; Kishikawa, Nobusuke; Tazuma, Susumu

doi:10.1002/jhbp.333

Cited by 13 publications

(9 citation statements)

References 34 publications

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“…Remarkably, ROS can interact directly with HSCs, which are the main executors of fibrogenesis to generate ECM. The cellular redox environment could regulate the entry of quiescent HSCs into activated cycle [24, 84]. Redox-sensitive transcription factors such as NF- κ B are important to regulate the activities of antioxidant enzymes that mediate ROS signaling.…”

Section: The Relationship and Interdependence Between Oxidative Stmentioning

confidence: 99%

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

Hong

Tan

et al. 2016

Oxidative Medicine and Cellular Longevity

272

179

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The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notably, increasing evidences showed that oxidative stress and inflammation are tightly related, which are regarded as essential partners that present simultaneously and interact with each other in various pathological conditions, creating a vicious cycle to aggravate the hepatic diseases. Clarifying the interaction of oxidative stress and inflammation is of great importance to provide new directions and targets for developing therapeutic intervention. Herein, this review is concerned with the regulation and interdependence of oxidative stress and inflammation in a variety of liver diseases. In addition to classical mediators and signaling, particular emphasis is placed upon immune suppression, a potential linkage of oxidative stress and inflammation, to provide new inspiration for the treatment of liver diseases. Furthermore, since antioxidation and anti-inflammation have been extensively attempted as the strategies for treatment of liver diseases, the application of herbal medicines and their derived compounds that protect liver from injury via regulating oxidative stress and inflammation collectively were reviewed and discussed.

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Section: The Relationship and Interdependence Between Oxidative Stmentioning

confidence: 99%

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

Hong

Tan

et al. 2016

Oxidative Medicine and Cellular Longevity

272

179

View full text Add to dashboard Cite

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“…Furthermore, NADPH oxidase NOX-generated ROS has been suggested to play a preeminent role in the pathogenesis of liver fibrosis by promoting myofibroblast activation [40]. Regardless of etiology, these ROS can directly activate the prime executors of fibrogenesis i-e, hepatic stellate cells (HSCs) to transform into myofibroblasts and produce ECM proteins and further enhance the cellular oxidative stress and inflammation [3,41]. Reflexively, this redox-sensitive cascade results in the onset and exasperation of redox-related progression of liver fibrosis [7,35].…”

Section: Oxidative Stress Mediated Biomarkersmentioning

confidence: 99%

Elucidating Potential Profibrotic Mechanisms of Emerging Biomarkers for Early Prognosis of Hepatic Fibrosis

Zehra

Curry

Pillai

et al. 2020

IJMS

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Hepatic fibrosis has been associated with a series of pathophysiological processes causing excessive accumulation of extracellular matrix proteins. Several cellular processes and molecular mechanisms have been implicated in the diseased liver that augments fibrogenesis, fibrogenic cytokines and associated liver complications. Liver biopsy remains an essential diagnostic tool for histological evaluation of hepatic fibrosis to establish a prognosis. In addition to being invasive, this methodology presents with several limitations including poor cost-effectiveness, prolonged hospitalizations, and risks of peritoneal bleeding, while the clinical use of this method does not reveal underlying pathogenic mechanisms. Several alternate noninvasive diagnostic strategies have been developed, to determine the extent of hepatic fibrosis, including the use of direct and indirect biomarkers. Immediate diagnosis of hepatic fibrosis by noninvasive means would be more palatable than a biopsy and could assist clinicians in taking early interventions timely, avoiding fatal complications, and improving prognosis. Therefore, we sought to review some common biomarkers of liver fibrosis along with some emerging candidates, including the oxidative stress-mediated biomarkers, epigenetic and genetic markers, exosomes, and miRNAs that needs further evaluation and would have better sensitivity and specificity. We also aim to elucidate the potential role of cardiotonic steroids (CTS) and evaluate the pro-inflammatory and profibrotic effects of CTS in exacerbating hepatic fibrosis. By understanding the underlying pathogenic processes, the efficacy of these biomarkers could allow for early diagnosis and treatment of hepatic fibrosis in chronic liver diseases, once validated.

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“…Several studies have shown a relationship between hypertension and NAFLD from the viewpoint of prevalence, natural course, and effects of antihypertensive agents [3][4][5][6][7]. Our previous studies reported that a reduction in antioxidant capacity played a critical role in the development of both steatosis and fibrosis in a hypertensive NAFLD model [8,9].…”

Section: Introductionmentioning

confidence: 96%

“…Systolic blood pressure (BP) and diastolic BP in 7‐week‐old SHR have been reported to be 161 ± 5 and 133 ± 5 mmHg, respectively . We previously described a hypertensive NAFLD model without obesity and DM by feeding SHRs a choline‐deficient (CD) diet for 5 weeks .…”

Section: Introductionmentioning

confidence: 99%

Decrease in major secondary bile acid, hyodeoxycholic acid, was the main alteration in hepatic bile acid compositions in a hypertensive nonalcoholic fatty liver disease model

Kodama

Kanno

Kishikawa

et al. 2019

J Hepato Biliary Pancreat

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Background Previous findings on hepatic bile acid compositions in nonalcoholic fatty liver disease (NAFLD) have been inconsistent and complicated. The aim of this study was to investigate the effects of steatosis on hepatic bile acid composition in a hypertensive NAFLD model without obesity and diabetes mellitus and compare hepatic bile acid composition between hypertensive rats with and without steatosis. Methods Two groups of hypertensive rats were studied: spontaneously hypertensive rats (SHR) fed with a normal diet (SHR‐N) or a choline‐deficient diet (SHR‐CD). Two groups of normotensive rats were studied: Wistar Kyoto rats (WKY) fed a normal diet (WKY‐N) or a choline‐deficient diet (WKY‐CD). Hepatic bile acid analysis was performed using liquid chromatography–electrospray ionization–tandem mass spectrometry. Results Regarding bile acid composition, the hyodeoxycholic acid (HDCA) species in the SHR‐CD group showed the largest change in bile acid composition, significantly decreasing to 21.9% of that found in the SHR‐N group. In the WKY‐CD group, no reduction of HDCA species was observed. Conclusions We demonstrated that the decrease in HDCA species was the main alteration in a hypertensive NAFLD model. It was suggested that the decrease in HDCA species in the SHR‐CD group was caused by dysbiosis.

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Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline‐deficient diet: a follow‐up report on long‐term effects of oxidative stress in non‐alcoholic fatty liver disease

Abstract: Hypertension precipitated hepatic steatosis, and further, acts as an enhancer in NAFLD progression to liver fibrosis through oxidative stress.

Cited by 13 publications

References 34 publications

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

Elucidating Potential Profibrotic Mechanisms of Emerging Biomarkers for Early Prognosis of Hepatic Fibrosis

Decrease in major secondary bile acid, hyodeoxycholic acid, was the main alteration in hepatic bile acid compositions in a hypertensive nonalcoholic fatty liver disease model

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