Enhancing language performance with non-invasive brain stimulation—A transcranial direct current stimulation study in healthy humans

Sparing, Roland; Dafotakis, Manuel; Meister, Ingo G.; Thirugnanasambandam, Nivethida; Fink, Gereon R.

doi:10.1016/j.neuropsychologia.2007.07.009

Cited by 205 publications

(134 citation statements)

References 56 publications

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“…So far, there is growing evidence that the integrity and strength of spontaneous functional connectivity in several networks are of behavioral and cognitive relevance (Massimini et al, 2005;Hampson et al, 2006;He et al, 2007;Schacter et al, 2007;Kelly et al, 2008;Schilbach et al, 2008;Lewis et al, 2009;Ferrarelli et al, 2010;Wirth et al, 2011). Thus, our findings may explain why a wide range of cognitive domains has already been successfully modulated by prefrontal tDCS Sparing et al, 2008;Cerruti and Schlaug, 2009;Dockery et al, 2009;Elmer et al, 2009;Fertonani et al, 2010;Hecht et al, 2010;Ambrus et al, 2011;Fiori et al, 2011). Within this range of cognitive domains, we have recently shown that prefrontal tDCS using similar stimulation parameters as in the current study, led to an improvement of working memory performance (n-back) associated with changes in EEG activity patterns (Keeser et al, 2011).…”

Section: Effects Of Tdcs On Rsnsmentioning

confidence: 59%

“…Anodal tDCS of the dorsolateral prefrontal cortex (DLPFC) with the cathode placed over the contralateral supraorbital region has been found to improve performance in several cognitive domains, including executive functions, verbal skills, and memory performance in healthy subjects (Iyer et al, 2005;Wassermann and Grafman, 2005;Cerruti and Schlaug, 2009;Sparing et al, 2008;Dockery et al, 2009;Fiori et al, 2011), as well as in patients with Parkinson's disease and stroke Jo et al, 2009). Promising pilot data suggest a positive therapeutic effect in patients with major depression Boggio et al, 2008;Rigonatti et al, 2008;Ferrucci et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Keeser¹,

Meindl²,

Bor³

et al. 2011

J. Neurosci.

526

363

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Transcranial direct current stimulation (tDCS) has been proposed for experimental and therapeutic modulation of regional brain function. Specifically, anodal tDCS of the dorsolateral prefrontal cortex (DLPFC) together with cathodal tDCS of the supraorbital region have been associated with improvement of cognition and mood, and have been suggested for the treatment of several neurological and psychiatric disorders. Although modeled mathematically, the distribution, direction, and extent of tDCSmediated effects on brain physiology are not well understood. The current study investigates whether tDCS of the human prefrontal cortex modulates resting-state network (RSN) connectivity measured by functional magnetic resonance imaging (fMRI). Thirteen healthy subjects underwent real and sham tDCS in random order on separate days. tDCS was applied for 20 min at 2 mA with the anode positioned over the left DLPFC and the cathode over the right supraorbital region. Patterns of resting-state brain connectivity were assessed before and after tDCS with 3 T fMRI, and changes were analyzed for relevant networks related to the stimulation-electrode localizations. At baseline, four RSNs were detected, corresponding to the default mode network (DMN), the left and right frontal-parietal networks (FPNs) and the self-referential network. After real tDCS and compared with sham tDCS, significant changes of regional brain connectivity were found for the DMN and the FPNs both close to the primary stimulation site and in connected brain regions. These findings show that prefrontal tDCS modulates resting-state functional connectivity in distinct functional networks of the human brain.

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Section: Effects Of Tdcs On Rsnsmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Keeser¹,

Meindl²,

Bor³

et al. 2011

J. Neurosci.

526

363

View full text Add to dashboard Cite

show abstract

“…In tDCS, a weak electrical current is directly applied to the head to generate an electrical field that modulates neuronal activity (see Paulus, this issue). Anodal tDCS (atDCS) has a general facilitation effect and causes membrane depolarisation, whereas cathodal tDCS (ctDCS) has a general inhibitory effect and causes membrane hyperpolarisation (cathodal stimulation, see Liebetanz, Nitsche, Tergau, & Paulus, 2002 (Nitsche et al, 2003;Reis et al, 2009), working memory (Fregni et al, 2005;Ohn et al, 2008), pitch memory (Vines, Schnider, & Schlaug, 2006), perception (Antal et al, 2004), and language (Fertonani, Rosini, Cotelli, Rossini, & Miniussi, 2010;Iyer et al, 2005;Sparing, Dafotakis, Meister, Thirugnanasambandam, & Fink, 2008). Interestingly, and particularly relevant to the neurorehabilitation field, these tDCS-induced modifications of cortical excitability and behaviour can outlast the stimulation period itself.…”

Section: Introductionmentioning

confidence: 99%

Anomia training and brain stimulation in chronic aphasia

Cotelli

Fertonani

Miozzo

et al. 2011

Neuropsychological Rehabilitation

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Recent studies have reported enhanced performance on language tasks induced by non-invasive brain stimulation, i.e., repetitive transcranial magnetic stimulation (rTMS), or transcranial direct current stimulation (tDCS), in patients with aphasia due to stroke or Alzheimer's disease (AD). The first part of this article reviews brain stimulation studies related to language recovery in aphasic patients. The second part reports results from a pilot study with three chronic stroke patients who had non-fluent aphasia, where real or placebo rTMS was immediately followed by 25 minutes of individualised speech therapy. Real rTMS consisted of high-frequency rTMS over the left dorsolateral prefrontal cortex (BA 8/9) for 25 minutes. Each patient underwent a total of four weeks of intervention. P1 underwent four weeks of real rTMS (5 days/week) where individualised speech therapy was provided for 25 minutes immediately following each rTMS session. P2 and P3 each underwent two weeks of placebo rTMS, followed immediately by individualised speech therapy; then two weeks of real rTMS, followed immediately by individualised speech therapy. Assessments took place at 2, 4, 12, 24 and 48 weeks post-entry/baseline testing. Relative to entry/baseline testing, a significant improvement in object naming was observed at all testing times, from two weeks post-intervention in real rTMS plus speech therapy, or placebo rTMS plus speech therapy. Our findings suggest beneficial effects of targeted behavioural training in combination with brain stimulation in chronic aphasic patients. However, further work is required in order to verify whether optimal combination parameters (rTMS alone or speech therapy alone) and length of rTMS treatment may be found.

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“…Cette é tude a permis de mettre en é vidence l'importance d'une intensité suffisante pour induire un effet bé né fique sur le langage. L'effet d'une stimulation des aires de Wernicke et de Broca a é galement é té é tudié , montrant une augmentation de la rapidité de ré ponse à la dé nomination d'objets (Sparing et al, 2008) et une amé lioration de l'aisance verbale ainsi qu'une meilleure performance lors d'une tâ che de fluence sé mantique et phoné mique (Cattaneo et al, 2011). Contrairement aux pré cé dents ré sultats, la stimulation cathodique peut s'avé rer bé né fique dans le cadre d'une aphasie de Broca à la suite d'un AVC (Monti et al, 2008).…”

Section: Effets Sur Le Langageunclassified

La stimulation transcrânienne à courant continu : un nouvel outil de neurostimulation

Thibaut¹,

Chatelle²,

Gosseries³

et al. 2013

Revue Neurologique

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Enhancing language performance with non-invasive brain stimulation—A transcranial direct current stimulation study in healthy humans

Cited by 205 publications

References 56 publications

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Anomia training and brain stimulation in chronic aphasia

La stimulation transcrânienne à courant continu : un nouvel outil de neurostimulation

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