Enhancing probe’s sensitivity for peroxynitrite through alkoxy modification of dicyanovinylchromene

Yu, Hui; Fang, Ying; Wang, Jun; Zhang, Qi; Chen, Shaojin; Wang, Kun-Peng; Hu, Zhi‐Qiang

doi:10.1007/s00216-022-04239-5

Cited by 11 publications

(2 citation statements)

References 47 publications

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“…When the fluorophore molecule is exposed to the target, the degree of charge transfer changes, resulting in a “turn-on” effect response of fluorescence or a shift in wavelength [ 84 ]. Up to now, some FOSMPs based on ICT mechanism have been designed [ 63 , 64 , 65 , 66 , 67 , 68 ]. For example, Xiong et al [ 63 ] designed an ICT-based probe for CN - detection.…”

Section: Fosmps For Bioimaging and Detectionmentioning

confidence: 99%

Fluorescent Organic Small Molecule Probes for Bioimaging and Detection Applications

et al. 2022

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The activity levels of key substances (metal ions, reactive oxygen species, reactive nitrogen, biological small molecules, etc.) in organisms are closely related to intracellular redox reactions, disease occurrence and treatment, as well as drug absorption and distribution. Fluorescence imaging technology provides a visual tool for medicine, showing great potential in the fields of molecular biology, cellular immunology and oncology. In recent years, organic fluorescent probes have attracted much attention in the bioanalytical field. Among various organic fluorescent probes, fluorescent organic small molecule probes (FOSMPs) have become a research hotspot due to their excellent physicochemical properties, such as good photostability, high spatial and temporal resolution, as well as excellent biocompatibility. FOSMPs have proved to be suitable for in vivo bioimaging and detection. On the basis of the introduction of several primary fluorescence mechanisms, the latest progress of FOSMPs in the applications of bioimaging and detection is comprehensively reviewed. Following this, the preparation and application of fluorescent organic nanoparticles (FONPs) that are designed with FOSMPs as fluorophores are overviewed. Additionally, the prospects of FOSMPs in bioimaging and detection are discussed.

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Section: Fosmps For Bioimaging and Detectionmentioning

confidence: 99%

Fluorescent Organic Small Molecule Probes for Bioimaging and Detection Applications

et al. 2022

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“…The DCV group serves as a Michael acceptor for nucleophilic analytes, such as bisulfite, biothiols, and amines . The DCV group is also responsive to electrophilic analytes such as hypochlorous acid and peroxynitrite, which react with the carbon–carbon double bond. Besides, the DCV group can also serve as the electron acceptor in the electron donor–acceptor-type dipolar fluorophores, which show environment-sensitive emission behavior and thus are used for observing the cellular viscosity and polarity change.…”

Section: Introductionmentioning

confidence: 99%

Dissecting the Crosstalk between Bisulfite and Hypochlorous Acid in the Reaction-Based Fluorescence Detection with Dicyanovinyl-Based Probes

et al. 2023

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Fluorescent probes bearing a reactive moiety of 1,1dicyanovinyl are known to detect several biological species including bisulfite and hypochlorous acid, which, however, possess a selectivity issue among those analytes. Structural modifications of the reactive group for optimal steric and electron effects based on theoretical calculations led us to address the selectivity issue, offering new reactive moieties that provide complete analyte selectivity, including that between bisulfite and hypochlorous acid, in cells as well as in solution.

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A rationally designed fluorescent probe for sulfur dioxide and its derivatives: applications in food analysis and bioimaging

Fang,

Zheng,

Zhang

et al. 2023

Anal Bioanal Chem

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Enhancing probe’s sensitivity for peroxynitrite through alkoxy modification of dicyanovinylchromene

Cited by 11 publications

References 47 publications

Fluorescent Organic Small Molecule Probes for Bioimaging and Detection Applications

Fluorescent Organic Small Molecule Probes for Bioimaging and Detection Applications

Dissecting the Crosstalk between Bisulfite and Hypochlorous Acid in the Reaction-Based Fluorescence Detection with Dicyanovinyl-Based Probes

A rationally designed fluorescent probe for sulfur dioxide and its derivatives: applications in food analysis and bioimaging

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