Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate

Abstract

Background-A new intracellular adenosine triphosphate (ATP) delivery technique has been developed and was tested for skin wound care.

Low‐level light stimulates excisional wound healing in mice

“…The activation of this enzyme leads to an increase in the production of ATP that is required for numerous cellular functions providing both energy and phosphates required for the regulation of cellular functions. Moreover, addition of external ATP was shown to stimulate wound healing in an animal model [34]. Although no increase in contraction was found in mice treated with external ATP, in vitro observations suggest that ATP increases wound contraction by serving both as an energy source for generation of contractile force and motility, and as a phosphate donor for kinase reactions regulating contraction [35,36].…”

The Continued Promise of Neuroprotection for Acute Stroke Treatment

“…Liposome encapsulated adenosine triphosphate (ATP) (Arakawa et al, 1998) can be used for direct energy delivery and has shown a protective effect in intestinal injury from hemorrhagic shock (Zakaria el et al, 2005) and skin wound healing (Chiang et al, 2007). Because of the enriched purinergic receptors in nerve cells, direct energy delivery has not been successful in the nervous system.…”

Purinergic Signaling and Blood Vessels in Health and Disease

“…Improvement of ischemic skin flap survival used in surgery when exposed to ATP has been described (Boss et al, 1984;Cikrit et al, 1984;Zimmerman et al, 1987;Knight et al, 1989), perhaps because of its vasodilator effects (Kuzon et al, 1985). Direct Mg-ATP delivery to cutaneous wounds accelerates healing, perhaps by increasing synthesis of vascular endothelial growth factor (Chiang et al, 2007).…”