Enhancing the antitumor immunosurveillance of PD-L1-targeted gene therapy for metastatic melanoma using cationized Panax Notoginseng polysaccharide

Ma, Mengya; Liu, Xiaobin; Ma, Chaoqun; Guo, Ruyue; Zhang, Xueling; Zhang, Zhenzhong; Ren, Xueling

doi:10.1016/j.ijbiomac.2022.11.242

Cited by 11 publications

(7 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 Polysaccharides can resist tumor development by activating macrophages and lymphocytes, promoting cytokine secretion, and improving host antitumor immune function. [19][20][21] Macrophages are the primary immunoregulatory cells in tumors and play a vital role in the tumor immune response. 22 The polarization of TAMs is ubiquitous in tumorigenesis and development.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Sambucus adnata Polysaccharide SPS-1 Inhibits Growth of Transplanted Lung Cancer via Polarizing Tumor Associated Macrophage From M2 into M1

Yuan

2023

Natural Product Communications

View full text Add to dashboard Cite

Macrophages are the primary immune cells in the tumor microenvironment, where they exhibit the immunosuppressive M2 phenotype to support tumor development. Reshaping M2 tumor-associated macrophages (TAMs) into the antitumor M1 phenotype is a promising approach in tumor immunotherapy. We had previously demonstrated that a high-purity homogeneous Sambucus adnata wall polysaccharide SPS-1 isolated from S. adnata exerted a good immunoregulatory effect. In the present study, we explored whether SPS-1 can remodel TAMs and inhibit the development of lung cancer. In the tumor mouse model transplanted with Lewis lung cancer, SPS-1 promoted the apoptosis of tumor cells and inhibited angiogenesis in tumor tissues by remodeling M2 macrophages in the tumor microenvironment into M1 macrophages, which exerted effective antitumor effects. Therefore, SPS-1 may be used as a novel immunostimulator in tumor immunotherapy, and our study also provides a novel pathway and material for reshaping immune defense to prevent and treat tumors.

show abstract

Section: Conclusion and Discussionmentioning

confidence: 99%

Sambucus adnata Polysaccharide SPS-1 Inhibits Growth of Transplanted Lung Cancer via Polarizing Tumor Associated Macrophage From M2 into M1

Yuan

2023

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…The designed PNP-PEI loaded with short hairpin RNA targeting the PD-L1 exhibited immunopotentiating therapeutic results in tumor immunotherapy. 466 Furthermore, advances in the utilization of poly(ethylene glycol)-grafted-polyethylenimine (PEI-g-PEG) as a delivery vehicle for mRNA therapeutics have been noteworthy. Specifically, different terminal functional groups and grafting ratios of PEG were explored for their influence on transgene expression levels.…”

Section: Diverse Polymer Selection Based On Therapeuticmentioning

confidence: 99%

“…Positively charged PEI has also been grafted onto the backbone of Panax notoginseng polysaccharide (PNP) to enable charge reversal and produce a functional RNA vector (PNP-PEI). The designed PNP-PEI loaded with short hairpin RNA targeting the PD-L1 exhibited immunopotentiating therapeutic results in tumor immunotherapy . Furthermore, advances in the utilization of poly(ethylene glycol)-grafted-polyethylenimine (PEI-g-PEG) as a delivery vehicle for mRNA therapeutics have been noteworthy.…”

Section: Chemical Modifications On Rna Nanodelivery Platformsmentioning

confidence: 99%

Chemically Modified Platforms for Better RNA Therapeutics

Shi,

Zhen,

Zhang

et al. 2024

Chem. Rev.

View full text Add to dashboard Cite

RNA-based therapies have catalyzed a revolutionary transformation in the biomedical landscape, offering unprecedented potential in disease prevention and treatment. However, despite their remarkable achievements, these therapies encounter substantial challenges including low stability, susceptibility to degradation by nucleases, and a prominent negative charge, thereby hindering further development. Chemically modified platforms have emerged as a strategic innovation, focusing on precise alterations either on the RNA moieties or their associated delivery vectors. This comprehensive review delves into these platforms, underscoring their significance in augmenting the performance and translational prospects of RNA-based therapeutics. It encompasses an in-depth analysis of various chemically modified delivery platforms that have been instrumental in propelling RNA therapeutics toward clinical utility. Moreover, the review scrutinizes the rationale behind diverse chemical modification techniques aiming at optimizing the therapeutic efficacy of RNA molecules, thereby facilitating robust disease management. Recent empirical studies corroborating the efficacy enhancement of RNA therapeutics through chemical modifications are highlighted. Conclusively, we offer profound insights into the transformative impact of chemical modifications on RNA drugs and delineates prospective trajectories for their future development and clinical integration. CONTENTS1. Introduction 930 2. Current Status and Challenges of RNA Therapeutics in Clinics 933 2.1. Molecular Mechanisms and Clinical Research Progress of RNAs 934 2.1.1. ASO 934 2.1.2. siRNA 934 2.1.3. Aptamer 936 2.1.4. mRNA 936 2.1.5. RNA Therapeutics on the Cusp of Clinical Breakthroughs 938 2.2. Major Challenges of Current RNA Therapeutics in Clinics 940 2.

show abstract

“…Astragalus membranaceus root extract Polysaccharide nanoparticles [8,9] Cellobiose Cryoprotectant for liposomes [10] Chia seed oil from Salvia hispanica L. Liposomes and nanoemulsions [11] Chitosan extracted from fungi (Aspergillus niger; Agaricus bisporus) Chitosan nanoparticles [8,12,13] Chondroitin sulphate (synthetic) Polysaccharide nanoparticles [14][15][16] Coagulated potato proteins Protein-based nanoparticles [17,18] Dextran from Leuconostoc mesenteroides Polysaccharide nanoparticles Reviewed by [19] Digitaria exilis Polysaccharide nanoparticles [20] Eggshell membrane protein hydrolysate Protein-based nanoparticles [21][22][23] Fucoidan extracted from the seaweed Fucus vesiculosus and Undaria pinnatifida Polysaccharide nanoparticles [24][25][26] Guar gum Polysaccharide nanoparticles [27] Lucerne leaf extract from Medicago sativa Protein-based nanoparticles [28] Mung bean seed proteins from Vigna radiata Protein-based nanoparticles [29,30] Panax notoginseng root extract Polysaccharide nanoparticles [31] Phytoglycogen Polysaccharide nanoparticles Polyelectrolyte complex [32][33][34][35][36][37] Phytosterols Solid lipid nanoparticles Liposomes [38,39] Phospholipids from egg yolk Liposomes [40][41][42] Phosphatidylserine from soya and fish phospholipids Liposomes [43,44] Rapeseed protein from Brassica nap...…”

Section: Material(s) From Novel Foods Type Of Carrier Referencesmentioning

confidence: 99%

Combination of Nanodelivery Systems and Constituents Derived from Novel Foods: A Comprehensive Review

Truzzi,

Bertelli,

Bilia

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Novel Food is a new category of food, regulated by the European Union Directive No. 2015/2283. This latter norm defines a food as “Novel” if it was not used “for human consumption to a significant degree within the Union before the date of entry into force of that regulation, namely 15 May 1997”. Recently, Novel Foods have received increased interest from researchers worldwide. In this sense, the key areas of interest are the discovery of new benefits for human health and the exploitation of these novel sources of materials in new fields of application. An emerging area in the pharmaceutical and medicinal fields is nanotechnology, which deals with the development of new delivery systems at a nanometric scale. In this context, this review aims to summarize the recent advances on the design and characterization of nanodelivery systems based on materials belonging to the Novel Food list, as well as on nanoceutical products formulated for delivering compounds derived from Novel Foods. Additionally, the safety hazard of using nanoparticles in food products, i.e., food supplements, has been discussed in view of the current European regulation, which considers nanomaterials as Novel Foods.

show abstract

Enhancing the antitumor immunosurveillance of PD-L1-targeted gene therapy for metastatic melanoma using cationized Panax Notoginseng polysaccharide

Cited by 11 publications

References 43 publications

Sambucus adnata Polysaccharide SPS-1 Inhibits Growth of Transplanted Lung Cancer via Polarizing Tumor Associated Macrophage From M2 into M1

Sambucus adnata Polysaccharide SPS-1 Inhibits Growth of Transplanted Lung Cancer via Polarizing Tumor Associated Macrophage From M2 into M1

Chemically Modified Platforms for Better RNA Therapeutics

Combination of Nanodelivery Systems and Constituents Derived from Novel Foods: A Comprehensive Review

Contact Info

Product

Resources

About