Enhancing the Effect of Pharmacological Ascorbate in Cancer Therapy via Acid‐Triggered Ferritin Nanoparticles

Xu, Nuo; Yang, Yuanfan; Chen, Long; Xu, Liang; Xu, Xiaojie; Lin, Jian

doi:10.1002/adbi.201900006

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…Herein, we developed a carrier-and-deliver system to efficaciously deliver copper ions to tumor tissues. Human ferritin (Fn) protein, which self-assembles into a 24-mer nanocage and possesses the ability to encapsulate metal ions in its cavity, − was chosen as the carrier module. − Albumin, which is the most abundant component in serum and is highly uptaken in multiple tumors, was chosen as the deliverer module toward the tumor. The ferritin–albumin–Cu nanoparticle (FHC NP) was thus invented.…”

Section: Introductionmentioning

confidence: 99%

A Ferritin–Albumin–Cu Nanoparticle that Efficaciously Delivers Copper(II) Ions to a Tumor and Improves the Therapeutic Efficacy of Disulfiram

Yang

Chen

et al. 2020

ACS Omega

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The application of disulfiram can be traced back to the 1920s, from when it was utilized to facilitate alcohol abstinence by producing allergic reactions toward alcohol. In previous research, combination of disulfiram and copper ions has demonstrated significant anti-tumor activity. However, both disulfiram and copper ions lack the ability of specific targeting to tumor tissues and may lead to a high risk of side effects, especially for copper ion, which is a kind of toxic heavy metal. Herein, a ferritin−albumin−Cu nanoparticle (FHC NP) was introduced. The nanoparticle was synthesized by first covalently cross-linking ferritin and albumin and then encapsulating the copper ions in the ferritin nanocage. The nanoparticle showed good accumulation in a tumor and when combined with disulfiram exhibited good in vitro selectivity toward cancer cells and better in vivo anti-tumor activity. Herein, the nanoparticle invented here represented a good strategy to efficaciously deliver copper ions into tumors and thus improve the therapeutic efficacy of disulfiram in tumor therapy.

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Section: Introductionmentioning

confidence: 99%

A Ferritin–Albumin–Cu Nanoparticle that Efficaciously Delivers Copper(II) Ions to a Tumor and Improves the Therapeutic Efficacy of Disulfiram

Yang

Chen

et al. 2020

ACS Omega

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Serum protein-based nanoparticles for cancer diagnosis and treatment

Iqbal

Yang

et al. 2021

Journal of Controlled Release

122

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Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology

Mohanty

Parida

Raut

et al. 2022

ACS Bio Med Chem Au

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The essence of bionanotechnology lies in the application of nanotechnology/nanomaterials to solve the biological problems. Quantum dots and nanoparticles hold potential biomedical applications, but their inherent problems such as low solubility and associated toxicity due to their interactions at nonspecific target sites is a major concern. The self-assembled, thermostable, ferritin protein nanocages possessing natural iron scavenging ability have emerged as a potential solution to all the above-mentioned problems by acting as nanoreactor and nanocarrier. Ferritins, the cellular iron repositories, are hollow, spherical, symmetric multimeric protein nanocages, which sequester the excess of free Fe(II) and synthesize iron biominerals (Fe2O3·H2O) inside their ∼5–8 nm central cavity. The electrostatics and dynamics of the pore residues not only drives the natural substrate Fe2+ inside ferritin nanocages but also uptakes a set of other metals ions/counterions during in vitro synthesis of nanomaterial. The current review aims to report the recent developments/understanding on ferritin structure (self-assembly, surface/pores electrostatics, metal ion binding sites) and chemistry occurring inside these supramolecular protein cages (protein mediated metal ion uptake and mineralization/nanoparticle formation) along with its surface modification to exploit them for various nanobiotechnological applications. Furthermore, a better understanding of ferritin self-assembly would be highly useful for optimizing the incorporation of nanomaterials via the disassembly/reassembly approach. Several studies have reported the successful engineering of these ferritin protein nanocages in order to utilize them as potential nanoreactor for synthesizing/incorporating nanoparticles and as nanocarrier for delivering imaging agents/drugs at cell specific target sites. Therefore, the combination of nanoscience (nanomaterials) and bioscience (ferritin protein) projects several benefits for various applications ranging from electronics to medicine.

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Enhancing the Effect of Pharmacological Ascorbate in Cancer Therapy via Acid‐Triggered Ferritin Nanoparticles

Cited by 3 publications

References 33 publications

A Ferritin–Albumin–Cu Nanoparticle that Efficaciously Delivers Copper(II) Ions to a Tumor and Improves the Therapeutic Efficacy of Disulfiram

A Ferritin–Albumin–Cu Nanoparticle that Efficaciously Delivers Copper(II) Ions to a Tumor and Improves the Therapeutic Efficacy of Disulfiram

Serum protein-based nanoparticles for cancer diagnosis and treatment

Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology

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