Enhancing the efficacy of photodynamic therapy by a chinese herbal medicine for hepatocellular carcinoma

Ma, Juan; Chen, Minhu; Dai, Yun; Qiao, Liang

doi:10.4161/cbt.5.9.3322

Cited by 7 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They found that Pa can significantly inhibit the growth of R-HepG2 cells [72]. It has been showed that Pa can enhance the efficacy of photodynamic therapy (PDT) for HCC, very likely due to its antiproliferative and pro-apoptotic effect [73–75]. …”

Section: Methodsmentioning

confidence: 99%

Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges

Martin

2011

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Use of herbal medicine in the treatment of liver cancer has a long tradition. The compounds derived from the herb and herbal composites are of considerable interest among oncologists. In the past, certain herbal compounds and herbal composite formulas have been studied through in vitro and in vivo as an anti-hepatocellular carcinoma (HCC) agent, enhancing our knowledge about their biologic functions and targets. However there is a significant distinction between the herbal medicine and the herbal production even though both are the plant-based remedies used in the practice. In this article, for the sake of clarity, the effective herbal compounds and herbal composite formulas against HCC are discussed, with emphasizing the basic conceptions of herbal medicine in order to have a better understanding of the prevention and treatment of HCC by herbal active compounds and herbal composite formulas.

show abstract

Section: Methodsmentioning

confidence: 99%

Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges

Martin

2011

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Light-activated Pa could significantly kill liver cancer, breast cancer, pancreatic cancer, and colon cancer cells [7,[14][15][16][17]. In this present study, we investigated apoptosis of pancreatic adenocarcinoma Capan-2 cells treated by LED-activated Pa.…”

Section: Discussionmentioning

confidence: 99%

“…Pheophorbide a (Pa), an active ingredient of Chinese herbal medicine Scutellaria Barbata and Silkworm Excreta, has been proven to be an effective photosensitizer [14][15][16]. Light-activated Pa could significantly kill liver cancer, breast cancer, pancreatic cancer, and colon cancer cells [7,[14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Apoptosis of pancreatic adenocarcinoma cells induced by LED-activated pheophorbide a

Liu¹,

Leung²,

Xia³

et al. 2010

Laser Phys. Lett.

View full text Add to dashboard Cite

Apoptosis is an important form of cell death. The present study investigated apoptotic cell death of pancreatic adenocarcinoma cells treated by LED‐activated pheophorbide a (Pa) using nuclear staining and flow cytometric analysis with Annexin V/PI staining 8 h after LED‐activated Pa. We further investigated the changes of mitochondrial membrane potential 3 h after LED‐activated Pa. The results showed that apoptosis significantly occurred and mitochondrial membrane potential markedly decreased in pancreatic adenocarcinoma cells after LED‐activated Pa. Our data demonstrated that LED‐activated Pa could remarkably induce apoptosis of pancreatic adenocarcinoma cells, and the collapse of mitochondrial membrane potential might be an important event in the apoptosis of pancreatic adenocarcinoma cells after LED‐activated Pa. (© 2011 by Astro Ltd., Published exclusively by WILEY‐VCH Verlag GmbH & Co. KGaA) (© 2011 by Astro Ltd., Published exclusively by WILEY‐VCH Verlag GmbH & Co. KGaA)

show abstract

“…Pheophorbide a (Pa) is from the extract from Chinese herbal medicine Scutellaria Barbata and Silkworm Excreta well-known to be helpful to treating tumor in traditional Chinese medicine [7]. Recent studies showed that pheophorbide a (Pa)-mediated photodynamic action could significantly deactivate liver cancer cells and suggested that Pa was a potential secondgeneration photosensitizer with improved physical, chemical and spectral properties [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, pheophorbide a (Pa) from Chinese herbal medicine Scutellaria Barbata and Silkworm Excreta, as a second-generation photosensitizer, is showing an important promise in the field of PDT on solid tumor. Several studies have indicated that Pa-mediated PDT has become a promising approach for deactivating liver cancer cells [7][8][9]. However, the light sources used currently in PDT mainly are quartz-tungsten-halogen bulbs and laser [3].…”

Section: Introductionmentioning

confidence: 99%

LED-activated pheophorbide a induces cellular destruction of colon cancer cells

Leung

Liu

et al. 2010

Laser Phys. Lett.

View full text Add to dashboard Cite

Pheophorbide a (Pa) from Chinese herbal medicine Scutellaria Barbata and Silkworm Excreta shows an important promise in the photodynamic therapy on malignant tumor. The present study investigated that LED-activated Pa induced the cellular destruction of colon cancer HT-29 cells. The results showed that Pa resulted in a drug-dose dependent photocytotoxicity in the HT-29 cells, meaning the photocytotoxicity of Pa depends on the drug concentration (0 -2 μM). We further investigated the apoptosis of the HT-29 cells 18 hours after photosensitization of Pa using a confocal laser scanning microscopy with Hoechst 33258 staining. These data demonstrated that LED-activated Pa could significantly induce the cellular destruction of the HT-29 cells.The nuclear features in the HT-29 cells 18 hours after PDT with Pa (0.5 μM, 1 J/cm 2 ) observed using CLSM with Hoechst 33258 staining. PDT with Pa

show abstract

Enhancing the efficacy of photodynamic therapy by a chinese herbal medicine for hepatocellular carcinoma

Cited by 7 publications

References 29 publications

Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges

Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges

Apoptosis of pancreatic adenocarcinoma cells induced by LED-activated pheophorbide a

LED-activated pheophorbide a induces cellular destruction of colon cancer cells

Contact Info

Product

Resources

About