Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate

Hsiao, Pa Fan; Peng, Sydney; Tang, Ting-Cheng; Lin, Shih‐Yin; Tsai, Hsieh‐Chih

doi:10.2147/ijn.s102599

Cited by 17 publications

(7 citation statements)

References 47 publications

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“…The positive charge imposed on the globular surface indicates stabilized and substantially emulsified CNE4 ferrying lipophilic LUT. OA is a hydrophobic compound and has been reported to provide highly monodispersed nanoparticles, which may be attributed its electrostatic repulsion among globules dispersed in the continuous phase [ 43 ]. Tsai et al investigated the significant impact of functionalized PEG-OA used as an amphiphilic surfactant for synthesis of gold nanoparticles for improved epidermal permeation and in vivo efficacy [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…OA is a hydrophobic compound and has been reported to provide highly monodispersed nanoparticles, which may be attributed its electrostatic repulsion among globules dispersed in the continuous phase [ 43 ]. Tsai et al investigated the significant impact of functionalized PEG-OA used as an amphiphilic surfactant for synthesis of gold nanoparticles for improved epidermal permeation and in vivo efficacy [ 43 ]. It was observed that LAB had a substantial impact on globular size (decreased from 373 nm to 158 nm) from CNE1 to CNE3 (1:1 to 1:3) which can be attributed to the relatively increased concentration of LAB in S mix , as observed in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…In this study, the imposed positivity on globular size of the developed nanoemulsions was purposely used to achieve (a) electrostatic interaction with skin cells, (b) augmented colloidal stability due to electrostatic repulsion between them, (c) increased skin permeation across the skin strata due to possible OA-PEG-mediated reversible changes in skin protein layer [ 43 ], and (d) reduced chances of Ostwald ripening [ 43 , 44 ]. All formulations were set at physiological pH (~7.4).…”

Section: Resultsmentioning

confidence: 99%

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Development and Evaluations of Transdermally Delivered Luteolin Loaded Cationic Nanoemulsion: In Vitro and Ex Vivo Evaluations

et al. 2021

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Introduction: Luteolin (LUT) is natural flavonoid with multiple therapeutic potentials and is explored for transdermal delivery using a nanocarrier system. LUT loaded cationic nanoemulsions (CNE1–CNE9) using bergamot oil (BO) were developed, optimized, and characterized in terms of in vitro and ex vivo parameters for improved permeation. Materials and methods: The solubility study of LUT was carried out in selected excipients, namely BO, cremophor EL (CEL as surfactant), labrasol (LAB), and oleylamine (OA as cationic charge inducer). Formulations were characterized with globular size, polydispersity index (PDI), zeta potential, pH, and thermodynamic stability studies. The optimized formulation (CNE4) was selected for comparative investigations (% transmittance as %T, morphology, chemical compatibility, drug content, in vitro % drug release, ex vivo skin permeation, and drug deposition, DD) against ANE4 (anionic nanoemulsion for comparison) and drug suspension (DS). Results: Formulations such as CNE1–CNE9 and ANE4 (except CNE6 and CNE8) were found to be stable. The optimized CNE4 based on the lowest value of globular size (112 nm), minimum PDI (0.15), and optimum zeta potential (+26 mV) was selected for comparative assessment against ANE4 and DS. The %T values of CNE1–CNE9 were found to be ˃95% and CEL content slightly improved the %T value. The spherical CNE4 was compatible with excipients and showed % total drug content in the range of 97.9–99.7%. In vitro drug release values from CNE4 and ANE4 were significantly higher than DS. Moreover, permeation flux (138.82 ± 8.4 µg/cm2·h), enhancement ratio (8.23), and DD (10.98%) were remarkably higher than DS. Thus, ex vivo parameters were relatively high as compared to DS which may be attributed to nanonization, surfactant-mediated reversible changes in skin lipid matrix, and electrostatic interaction of nanoglobules with the cellular surface. Conclusion: Transdermal delivery of LUT can be a suitable alternative to oral drug delivery for augmented skin permeation and drug deposition.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Development and Evaluations of Transdermally Delivered Luteolin Loaded Cationic Nanoemulsion: In Vitro and Ex Vivo Evaluations

et al. 2021

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“…[63] Hsiao and co-workers employed this approach to investigate the positive effects of polyethylene glycol (HS-PEG-COOH) and HS-PEG-oleylamine (OAm) functionalization on the skin permeation of spherical 10 nm AuNPs. [64] Using an in vivo rat model, they showed that PEG-and PEG-OAmfunctionalized AuNPs were able to overcome the skin barrier and deposit in the deeper subcutaneous adipose tissue. Moreover, the follicular deposition of AuNPs increased 2fold after PEG-OAm functionalization, demonstrating a preferential accumulation mediated by the stabilizing ligand.…”

Section: Figure 2 Schematic Representation Of Plasmonic Nps With Different Geometries (A) and Of The Human Skin Layers (B)mentioning

confidence: 99%

Bioconjugated Plasmonic Nanoparticles for Enhanced Skin Penetration

Alba‐Molina¹,

Giner‐Casares²,

Cano³

2019

Topics in Current Chemistry Collections

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Plasmonic nanoparticles (NPs) are one of the most promising and studied inorganic nanomaterials for different biomedical applications. Plasmonic NPs provide excellent biocompatibility, long-term stability against physical and chemical degradation, relevant optical properties, well-known synthesis methods and tuneable surface functionalities.Herein, a review of recently reported bioconjugated plasmonic NPs using different chemical approaches and loading cargoes (such as drug, gene, and proteins) for enhancement of transdermal delivery across biological tissues is presented. The main aim is the understanding of the interaction of the complex skin structure with biomimetic plasmonic NPs. This knowledge not only plays an important role for enhancing transdermal delivery of pharmaceutical formulations but also for controlling undesired skin penetration of industrial products, such as cosmetic, sunscreen formulations and any other mass-usage consumable containing nanoparticles.

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“…Moreover, PSI can hydrolyse into poly(aspartic acid) under physiological conditions and is excreted from the body through renal and other physiological processes [24][25][26][27][28][29]. Oleylamine (OA) is a fatty acid that has been utilised for biomedical applications such as transdermal and anticancer treatment [30][31][32]. Previously, PSI-OA has been used to enhance the biocompatibility of a 19 F magnetic resonance imaging agent [33].…”

Section: Introductionmentioning

confidence: 99%

Preparation of protein-loaded nanoparticles based on poly(succinimide)-oleylamine for sustained protein release: a two-step nanoprecipitation method

Chen,

Moonshi,

Nguyen

et al. 2023

Nanotechnology

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Currently, the treatment for acute disease encompasses the use of various biological drugs (BDs). However, the utilisation of BDs is limited due to its rapid clearance and non-specific accumulation in unwanted sites which results in a lack of therapeutic efficacy accompanied with adverse effects. While nanoparticles were considered a good candidate to resolve this problem, some available polymeric carriers for these BDs are mainly designed for long-term sustained release. Thus, there is a need to explore new polymeric carriers for diseases’ acute phase that requires sustained release of BDs in a short period such as thrombolysis and infec-tion. Poly(succinimide)-oleylamine (PSI-OA), a biocompatible polymer with tuneable dissolu-tion profile, represents a promising strategy to load BD for sustained release within a 48-hour period. In this work, we developed a two-step nanoprecipitation method to load the model protein (e.g. bovine serum albumin (BSA) and lipase) with PSI-OA. The characteristics of the nanoparticles were assessed based on various loading parameters, such as concentration, stir-ring rate, flow rate, volume ratios, dissolution, and the release of the protein. The optimised NPs displayed a size within 200 nm that is suitable for vasculature delivery to the target sites. These findings suggest that PSI-OA can be employed as a carrier for BDs for applications that require sustained release in a short period.

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Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate

Cited by 17 publications

References 47 publications

Development and Evaluations of Transdermally Delivered Luteolin Loaded Cationic Nanoemulsion: In Vitro and Ex Vivo Evaluations

Development and Evaluations of Transdermally Delivered Luteolin Loaded Cationic Nanoemulsion: In Vitro and Ex Vivo Evaluations

Bioconjugated Plasmonic Nanoparticles for Enhanced Skin Penetration

Preparation of protein-loaded nanoparticles based on poly(succinimide)-oleylamine for sustained protein release: a two-step nanoprecipitation method

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