Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles

Ban, Choongjin; Jo, Myeongsu; Park, Young Hyun; Kim, Jaehwan; Han, Jae Yong; Lee, Ki Won; Kweon, Dae-Hyuk; Choi, Young Jin

doi:10.1016/j.foodchem.2019.125328

Cited by 177 publications

(81 citation statements)

References 39 publications

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“…Carnosol and polyphenols in general are hydrophobic and have low intestinal absorption rate. To bypass these absorption problem researchers are experimenting with encapsulation approaches but we have not found any such studies for carnosol as is the case for polyphenols such as resveratrol [ 33 ] and curcumin [ 34 ]. A study by Soler-Rivas et al (2010) showed that carnosol present in a supercritical fluid extract of rosemary in sunflower oil (42 mg RE/g) is 62.59% bioaccessible to target tissues and increases to 87.85% by the addition of lecithin (37 mg/g) [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence

et al. 2020

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Cancer is characterized by unrestricted cell proliferation, inhibition of apoptosis, enhanced invasion and migration, and deregulation of signalling cascades. These properties lead to uncontrolled growth, enhanced survival, and the formation of tumours. Carnosol, a naturally occurring phyto-polyphenol (diterpene) found in rosemary, has been studied for its extensive antioxidant, anti-inflammatory, and anticancer effects. In cancer cells, carnosol has been demonstrated to inhibit cell proliferation and survival, reduce migration and invasion, and significantly enhance apoptosis. These anticancer effects of carnosol are mediated by the inhibition of several signalling molecules including extracellular signal-regulated kinase (ERK), p38, c-Jun N-terminal kinase (JNK), Akt, mechanistic target of rapamycin (mTOR) and cyclooxygenase-2 (COX-2). Additionally, carnosol prevents the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and promotes apoptosis, as indicated by increased levels of cleaved caspase-3, -8, -9, increased levels of the pro-apoptotic marker Bcl-2-associated X (BAX), and reduced levels of the anti-apoptotic marker B-cell lymphoma 2 (Bcl-2). The current review summarizes the existing in vitro and in vivo evidence examining the anticancer effects of carnosol across various tissues.

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Section: Introductionmentioning

confidence: 99%

Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence

et al. 2020

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“…Curcumin loaded in long-PEGylated [polyoxyethylene (100) stearyl ether, PEG100SE] SLNs showed greater absorption and long-term stability in rat after oral administration. In this study, bioavailability of curcumin can be increased 12-fold in PEG100SE (17.1 mM) formulated SLNs and 13.2-fold in PEG100SE (46.9 mM) formulated SLNs, whereas the short-PEGylated formulated SLNs does not (Ban et al, 2020 ). In another study, to overcome the initial burst release of SLNs, Huang et al applied sodium caseinate (NaCas) and sodium caseinate-lactose (NaCas-Lac) conjugates as bioemulsifiers to stabilize curcumin SLNs.…”

Section: Types Of Nanocurcumin Formulationsmentioning

confidence: 78%

Application of Functional Biocompatible Nanomaterials to Improve Curcumin Bioavailability

Shi

et al. 2020

Front. Chem.

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Curcumin is a lipophilic natural product extracted from turmeric and commonly used as a dietary spice. Being multi-functional, curcumin has been proposed in the prevention and treatment of a broad spectrum of diseases. However, due to unsatisfactory aqueous solubility and hence low bioavailability, clinical application of curcumin has been greatly restrained. To break these limitations, biocompatible nanoformulation, such as liposomes, nanoparticles, micelles, nanoemulsions and conjugates has been employed as alternatives to improve in vivo delivery of curcumin. In this scenario, in order to enhance bioavailability of curcumin, the choice of effective molecules as facilitators is of prominence. In this review, we focus on functional biocompatible materials, including polymers, protein molecules, polysaccharide, surface stabilizers and phospholipid complexes, and decipher their potential applications as how they assist to promote medicinal performance of curcumin.

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“…SLNs and NLCs have been applied in a wide variety of areas. Recent research from the last 2 years on SLN/NLC preparation include some important studies on the antiproliferative effect of cationic SLNs loaded with epigallocatechingallate (EGCG) against different cell lines [ 38 ], SLNs for the treatment of herpes simplex virus (HSV) infection [ 39 ], NLCs for antioxidant delivery [ 40 ], SLNs for food applications [ 41 ], and the enhancement of the oral bioavailability of curcumin through the use of SLNs [ 42 ]. Table 2 presents some examples of commercial lipids and surfactants used in SLN/NLC preparation, as well as some different applications.…”

Section: Solid Lipid Nanoparticles and Nanostructured Lipid Carriementioning

confidence: 99%

Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds

et al. 2020

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Phenolic compounds are one of the most widespread classes of compounds in nature, with several beneficial biological effects being associated with their anti-oxidant and anti-carcinogenic activities. Their application in the prevention or treatment of numerous chronic diseases have been studied, but a major drawback is still the low bioavailability of these compounds, as well as their instability towards pH, temperature, and light in some cases. Nanotechnology has emerged as an alternative to overcome these limitations, and the use of lipidic encapsulation systems is a promising technique to achieve an efficient drug delivery, protecting molecules from external factors and improving their bioavailability. In this review, solid lipid nanoparticles and nanostructured lipid carriers are highlighted as an important tool for the improvement of the bioavailability and stability of natural phenolic compounds, including their preparation methods and functionalization approaches and the discussion of several applications for putative use in cosmetic and pharmacologic products.

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Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles

Cited by 177 publications

References 39 publications

Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence

Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence

Application of Functional Biocompatible Nanomaterials to Improve Curcumin Bioavailability

Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds

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