Enhancing the Sensitivity of Needle-Implantable Electrochemical Glucose Sensors via Surface Rebuilding

Vaddiraju, Santhisagar; Legassey, Allen; Qiang, Liangliang; Wang, Yan; Burgess, Diane J.; Papadimitrakopoulos, Fotios

doi:10.1177/193229681300700221

Cited by 12 publications

(11 citation statements)

References 55 publications

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“…Although the linear detection range could be enhanced by restricting glucose transmission [33], there are still difficulties to collect effective signal and to produce the sensors at low cost. Moreover, the successive accumulation of H 2 O 2 in the reaction would result in electrode poisoning and the leakage would stimulate surrounding tissue [5,29,33]. An oxygen regeneration system prepared by immobilizing both GOD and Cat on sensing surface was proposed by Lucisano and Takashi et al [30,31].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the strong turnover rate of Cat to H 2 O 2 , using Cat on ampere electrode can eliminate the accumulation of H 2 O 2 in GOD and replenish oxygen, thereby ameliorating oxygen deficiency and ensuring the sufficient sensitivity to glucose [30][31][32]. However, immobilization of Cat on the same sensing plane restricts glucose reacting dose, and decreases GOD quantity [33]. Therefore, both of the two ways succeed at the cost of sensitivity decreasing.…”

Section: Introductionmentioning

confidence: 99%

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Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

et al. 2020

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This study aims to develop an oxygen regeneration layer sandwiched between multiple porous polyurethanes (PU) to improve the performance of implantable glucose sensors. Sensors were prepared by coating electrodes with platinum nanoparticles, Nafion, glucose oxidase and sandwich hierarchically porous membrane with an oxygen supplement function (SHPM-OS). The SHPM-OS consisted of a hierarchically porous structure synthesized by polyethylene glycol and PU and a catalase (Cat) layer that was coated between hierarchical membranes and used to balance the sensitivity and linearity of glucose sensors, as well as reduce the influence of oxygen deficiency during monitoring. Compared with the sensitivity and linearity of traditional non-porous (NO-P) sensors (35.95 nA/mM, 0.9987, respectively) and single porous (SGL-P) sensors (45.3 nA /mM, 0.9610, respectively), the sensitivity and linearity of the SHPM-OS sensor was 98.45 nA/mM and 0.9989, respectively, which was more sensitive with higher linearity. The sensor showed a response speed of five seconds and a relative sensitivity of 90% in the first 10 days and remained 78% on day 20. This sensor coated with SHPM-OS achieved rapid responses to changes of glucose concentration while maintaining high linearity for long monitoring times. Thus, it may reduce the difficulty of back-end hardware module development and assist with effective glucose self-management for people with diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

et al. 2020

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“…22 The majority of the hydrogen peroxide-detecting sensors are percutaneous devices that resemble either the “needle-type” sensor initially described by Shichiri et al 43 or the variant coil-type sensor. 45 Both sensors are of course suitable for in vivo use. Peroxide is oxidized amperometrically at platinum/iridum alloy working electrodes (+0.6 to +0.7 V vs. Ag|AgCl, 3 M KCl).…”

Section: Applications Of In Vivo Chemical Sensorsmentioning

confidence: 99%

In Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility

et al. 2016

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“…Nanoparticles may also be used to spatially organize electrochemical detectors. A needle-implantable electrochemical glucose sensor with excellent in vivo sensitivity was recently facilitated by generating a nanoporous working electrode via decoration with platinum nanoparticles 37. As the diversity of nanomaterials increases, so does their potential utility in the next generation of electrochemical biosensors.…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

Novel Molecular and Nanosensors for In Vivo Sensing

Eckert¹,

Vu²,

Zhang³

et al. 2013

Theranostics

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In vivo sensors are an emerging field with the potential to revolutionize our understanding of basic biology and our treatment of disease. In this review, we highlight recent advances in the fields of in vivo electrochemical, optical, and magnetic resonance biosensors with a focus on recent developments that have been validated in rodent models or human subjects. In addition, we discuss major challenges in the development and translation of in vivo biosensors and present potential solutions to these problems. The field of nanotechnology, in particular, has recently been instrumental in driving the field of in vivo sensors forward. We conclude with a discussion of emerging paradigms and techniques for the development of future biosensors.

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Enhancing the Sensitivity of Needle-Implantable Electrochemical Glucose Sensors via Surface Rebuilding

Abstract: Enhanced sensor performance in terms of sensitivity and large signal-to-noise ratio has been attained via electrochemical rebuilding of the WE. This approach also bypasses the need for conventional and nanostructured mediators currently employed to enhance sensor performance.

Cited by 12 publications

References 55 publications

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

In Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility

Novel Molecular and Nanosensors for In Vivo Sensing

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