Enhancing Transdermal Delivery of Glimepiride Via Entrapment in Proniosomal Gel

Abdallah, Marwa H.; Sabry, Shereen A.; Hasan, Azza A.

doi:10.5530/jyp.2016.4.8

Cited by 21 publications

(19 citation statements)

References 11 publications

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“…Currently, most the active pharmaceutical ingredients suffer from low solubility and bioavailability, which could be avoided via applying nanotechnology in developing drug delivery systems. A number of nanocarriers have been successfully developed, including nanoparticles, nanoemulsion, ethosome, niosome and liposome [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Quality by Design for Optimizing a Novel Liposomal Jojoba Oil-Based Emulgel to Ameliorate the Anti-Inflammatory Effect of Brucine

Abdallah

Elsewedy

Lila

et al. 2021

Gels

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One of the recent advancements in research is the application of natural products in developing newly effective formulations that have few drawbacks and that boost therapeutic effects. The goal of the current exploration is to investigate the effect of jojoba oil in augmenting the anti-inflammatory effect of Brucine natural alkaloid. This is first development of a formulation that applies Brucine and jojoba oil int a PEGylated liposomal emulgel proposed for topical application. Initially, various PEGylated Brucine liposomal formulations were fabricated using a thin-film hydration method. (22) Factorial design was assembled using two factors (egg Phosphatidylcholine and cholesterol concentrations) and three responses (particle size, encapsulation efficiency and in vitro release). The optimized formula was incorporated within jojoba oil emulgel. The PEGylated liposomal emulgel was inspected for its characteristics, in vitro, ex vivo and anti-inflammatory behaviors. Liposomal emulgel showed a pH of 6.63, a spreadability of 48.8 mm and a viscosity of 9310 cP. As much as 40.57% of Brucine was released after 6 h, and drug permeability exhibited a flux of 0.47 µg/cm2·h. Lastly, % of inflammation was lowered to 47.7, which was significant effect compared to other formulations. In conclusion, the anti-inflammatory influence of jojoba oil and Brucine was confirmed, supporting their integration into liposomal emulgel as a potential nanocarrier.

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Section: Introductionmentioning

confidence: 99%

Quality by Design for Optimizing a Novel Liposomal Jojoba Oil-Based Emulgel to Ameliorate the Anti-Inflammatory Effect of Brucine

Abdallah

Elsewedy

Lila

et al. 2021

Gels

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“…Whereas for niosomal formulations F TS and F SB it was 2.125 ± 0.44 and 2.375 ± 0.2314 hours respectively. The higher Tmax of niosomal formulations was owing to the slow dissolution and extended release of the drug from niosomes (Abdallah et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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2021

Pak. J. Pharm. Sci

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Cyclosporine A (CsA) is an immunosuppressant agent. Two niosomal formulations of CsA, F TS and F SB were formulated. Both formulations were studied in terms of size, polydispersity index (PDI), morphology and entrapment efficacy etc. Niosomal formulations F TS and F SB and plain aqueous dispersion were given to three assemblies of Albino rabbits (n=8 per group). CsA levels in plasma were determined at appropriate time intervals and pharmacokinetic parameters were evaluated. The percentage entrapment efficiencies of F TS and F SB were found to be 77.29 and 89.31% for respectively. Transmission electron microscopy results indicated spherical nature of niosomes. In vivo studies demonstrated that the value of Cmax for the F SB formulation was 1968.419 ng/ml and it was 1498.951 ng/ml and 1073.87 ng/ml for F TS and aqueous dispersion of CsA (control) respectively. It was found that both niosomal formulation F TS & F SB presented significantly high (p<0.05) Cmax, AUC0-t, MRT 0-inf and half-life (t1/2) as associated to plain drug dispersion. However niosomal formulation F SB exhibited better in-vivo performance as compared to F TS . It was established that CsA can be successfully entrapped in niosomes. So niosomes are promising vehicle for CsA oral delivery.

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“…The results reveal that formula 11 (tween 60, HLB= 14.9) has the highest EE% (58.43%) while Formula 15 (tween 60and40, HLB= 15.25) has the smallest EE% (9.52 %). These findings could be attributed to the affinity of cholesterol to lipophilic surfactant [16]. The results of in vitro release have shown that formula F1 (HLB= 14.9) has the highest release 97.5% compared to formula F7 (HLB= 15.25) which has the lowest in vitro release 89.1%.…”

Section: Determination Of Ee%mentioning

confidence: 96%

Diacerein-Loaded Niosomes (Dc-Ns): A New Technique to Sustain the Release of Drug Action

Kaoud

Heikal²,

Hammady

2022

Int J App Pharm

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Objective: The study's main goal is to develop a suitable niosomes (NS) encapsulated drug for anti-inflammatory effects such as diacerein (DC) and to evaluate the system's vesicle size (VS), entrapment efficiency (EE %), physical stability and in vitro release. Methods: Tween (40 and 60), cholesterol, and stearylamine were used in a 1:1:0.1 molar ratios as non-ionic surfactants. Thin film hydration was used to create the NS. Results: The higher EE% was observed with NS (F11) prepared from tween 60, cholesterol and 2.5 min sonication. These formulations' release patterns were Higuchi diffusion and first order. For the stability study, NS formulations were stored at temperature between 2-8 °C for 60 d retains the most drugs when compared to room and high temperature conditions. Conclusion: The findings of this study have conclusively shown that after NS encapsulation of DC, drug release is prolonged at a constant and controlled rate.

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Enhancing Transdermal Delivery of Glimepiride Via Entrapment in Proniosomal Gel

Cited by 21 publications

References 11 publications

Quality by Design for Optimizing a Novel Liposomal Jojoba Oil-Based Emulgel to Ameliorate the Anti-Inflammatory Effect of Brucine

Quality by Design for Optimizing a Novel Liposomal Jojoba Oil-Based Emulgel to Ameliorate the Anti-Inflammatory Effect of Brucine

Untitled

Diacerein-Loaded Niosomes (Dc-Ns): A New Technique to Sustain the Release of Drug Action

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