1980
DOI: 10.1161/01.hyp.2.4.395
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Enkephalin effects on blood pressure, heart rate, and baroreceptor reflex.

Abstract: The cardiovascular effects of opioid peptides have been studied. Leucine-enkephalin (Leu-ENK) produced blood pressure (BP) increases following administration into the lateral brain ventricles (i.v.t.), into the cisterna magna (i.c.i.), and following intravenous (i.v.) administration. Heart rate (HR) increases were observed following all routes of administration (threshold for BP and HR effects at 0.3 nmole, maximum at 360 nmoles). The cardiovascular effects were independent of generalized seizures, which may o… Show more

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Cited by 193 publications
(43 citation statements)
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“…The present study shows that the endogenous enkephalins ([Met] or [Leul enkephalin) or derivatives (DAMEA and DALEA), peptides known to evoke potent blood pressure changes in conscious rats (Schaz et al, 1980; Thornhill & Saunders, unpublished observations) do Carb -2.0 ± 0.2 -2.7 ± 0.9 -1.9 ± 0.6 NA + ME 3.0 ± 0.4 5.2 ± 0.3 3.6 ± 0.7 Iso + ME [Met] enkephalin on the peripheral vasculature cannot be ruled out (Sander et al, 1981). Eiden & Ruth (1982) indicated that [Met] and [Leu] enkephalin, P-endorphin and other pentapeptide derivatives had no effect on the basal beating rate of isolated atria of Sprague-Dawley rats.…”
Section: Discussionmentioning
confidence: 73%
“…The present study shows that the endogenous enkephalins ([Met] or [Leul enkephalin) or derivatives (DAMEA and DALEA), peptides known to evoke potent blood pressure changes in conscious rats (Schaz et al, 1980; Thornhill & Saunders, unpublished observations) do Carb -2.0 ± 0.2 -2.7 ± 0.9 -1.9 ± 0.6 NA + ME 3.0 ± 0.4 5.2 ± 0.3 3.6 ± 0.7 Iso + ME [Met] enkephalin on the peripheral vasculature cannot be ruled out (Sander et al, 1981). Eiden & Ruth (1982) indicated that [Met] and [Leu] enkephalin, P-endorphin and other pentapeptide derivatives had no effect on the basal beating rate of isolated atria of Sprague-Dawley rats.…”
Section: Discussionmentioning
confidence: 73%
“…3 Intra-ventricular injection of short chain peptides (leu and met encephalin) in awake animals, have been shown to result in hypertension and tachycardia. 5 Opiate antagonists have been shown to abolish this hypertensive response. 5 Epidural meperidine may well have a similar effect on the cardiovascular control centre, and cause hypertension.…”
Section: Discussionmentioning
confidence: 99%
“…However the mechanisms of action of opioids in inducing cardiovascular changes are not yet fully elucidated. In general the effects of administered Met-enkephalin and analogues on the cardiovascular sys-tem, especially blood pressure, depend on the animal species studied, route of administration and anaesthesia used thus causing an increase in blood pressure in conscious animals (Schaz et al, 1980;Yukimura et al:, 1981;Sander & Giles, 1982) or a decrease in blood pressure in anaesthetized animals (Wei et al, 1980;Eulie & Rhee, 1984). When tested, these effects are blocked by naloxone suggesting the involvement of opioid receptors.…”
Section: Introductionmentioning
confidence: 99%