Enrichment patterns of intrinsic disorder in proteins

Patil, Ashwini

doi:10.1007/s12551-022-01016-7

Cited by 2 publications

(1 citation statement)

References 63 publications

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“…Molecular evolution has posed varying degrees of selective pressure on protein dynamics (Patil, 2022). Some biological functions, mostly regulatory switches, involve proteins or protein regions that do not fold by themselves into an ordered threedimensional structure.…”

Section: Introductionmentioning

confidence: 99%

Protein structure and dynamics in the era of integrative structural biology

Grandori

2023

Front. Biophys.

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Proteins carry out their biological activity as dynamic structures and populate in solution or in biological membranes structural distributions with different degrees of heterogeneity. The central challenge in structural biology is to capture protein structural dynamics under equilibrium or kinetic conditions shifting from single, static pictures to movies of conformational ensembles. Ideally, this task should be pursued both in vitro and in vivo, under the influence of the native environment. The last decade has seen a tremendous development of biophysical methods for the investigation of protein structure and dynamics. However, each method has specific limitations and no single approach offers such a complex level of description. Nonetheless, the combination of experimental and computational, complementary methods is opening promising new avenues. Also the ambition of implementing structural studies on an “omic” scale is becoming more and more realistic. In spite of still major limitations, integrative structural biology is bringing dynamics into structural proteomics, with exciting perspectives for basic and applied sciences.

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Section: Introductionmentioning

confidence: 99%

Protein structure and dynamics in the era of integrative structural biology

Grandori

2023

Front. Biophys.

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Computational biophysics and structural biology of proteins—a Special Issue in honor of Prof. Haruki Nakamura’s 70th birthday

2022

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Receiving his initial training jointly in theoretical and applied physics at the University of Tokyo, Professor Haruki Nakamura has had a long and eventful scientific career, along the way helping to shape the way that biophysics is carried out in Japan. Concentrating his research efforts on the simulation of protein structure and function, he has, over his career arc, acted as director of the Institute for Protein Research (Osaka, Japan), director of the Protein Data Bank of Japan (PDBj), president of the Biophysical Society of Japan (BSJ), president of the Protein Science Society of Japan (PSSJ), and group leader and professor of Bioinformatics and Computational Structural Biology at Osaka University. In 2022, Prof. Haruki Nakamura turned 70 years old, and to mark this occasion, his scientific colleagues from around the world have combined their efforts to produce this Festschrift Issue of the IUPAB Biophysical Reviews journal around the theme of the computational biophysics and structural biology of proteins.

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Enrichment patterns of intrinsic disorder in proteins

Cited by 2 publications

References 63 publications

Protein structure and dynamics in the era of integrative structural biology

Protein structure and dynamics in the era of integrative structural biology

Computational biophysics and structural biology of proteins—a Special Issue in honor of Prof. Haruki Nakamura’s 70th birthday

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