Ensayo clínico de intervención en pacientes con hiperfibrinogenemia en prevención primaria de enfermedad cardiovascular en el ámbito de la atención primaria de salud

Cristobal, Juan José Rodríguez; Grote, C.A. Villaverde; Serra, Ferran; Mercadé, Pere Travé i; Santos, José Ma. Pérez; Sendra, Esther Peña

doi:10.1016/s0214-9168(08)72593-2

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“…This manuscript is a translation of our already published manuscript [ 1 ]. Fibrinogen can be considered an independent cardiovascular risk factor (CVRF) [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Randomised clinical trial of an intensive intervention in the primary care setting of patients with high plasma fibrinogen in the primary prevention of cardiovascular disease

Cristobal¹,

Alonso-Villaverde

Mercadé

et al. 2012

BMC Res Notes

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BackgroundWe have studied the possible effects of an intensive lifestyle change program on plasma fibrinogen levels, in patients with no cardiovascular disease, with elevated levels of fibrinogen, normal cholesterol levels, and a moderate estimated risk of coronary heart disease (CHD) and we have also analysed whether the effect on fibrinogen is independent of the effect on lipids.ResultsThis clinical trial was controlled, unblinded and randomized, with parallel groups, done in 13 Basic Health Areas (BHA) in l'Hospitalet de Llobregat (Barcelona) and Barcelona city. The study included 436 patients, aged between 35 and 75 years, with no cardiovascular disease, elevated levels of fibrinogen (> 300 mg/dl), cholesterol < 250 mg/dl, 218 of whom received a more intensive intervention consisting of advice on lifestyle and treatment. The follow-up frequency of the intervention group was every 2 months. The other 218 patients followed their standard care in the BHAs. Fibrinogen, plasma cholesterol and other clinical biochemistry parameters were assessed.The evaluation of the baseline characteristics of the patients showed that both groups were homogenous. Obesity and hypertension were the most prevalent risk factors. After 24 months of the study, statistically significant changes were seen between the adjusted means of the two groups, for the following parameters: fibrinogen, plasma cholesterol, systolic and diastolic blood pressure and body mass index.ConclusionIntensive intervention to achieve lifestyle changes has shown to be effective in reducing some of the estimated CHD factors. However, the effect of intensive intervention on plasma fibrinogen levels did not correlate with the variations in cholesterol.Trial RegistrationClinicalTrials.gov: NCT01089530

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“…This manuscript is a translation of our already published manuscript [ 1 ]. Fibrinogen can be considered an independent cardiovascular risk factor (CVRF) [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%