Ent-kaurenoic acid-enriched Mikania glomerata leaves-complexed β-cyclodextrin: Pharmaceutical development and in vivo antitumor activity in a sarcoma 180 mouse model

Ent-kaurane diterpenoids from the Annonaceae family: a review of research progress and call for further research

“…Alongside thirteen other natural isolates, KA was found to exhibit considerable antiproliferative effects in five cell lines, HeLa, A-549, Hep-2, PC-3, and MCF-7 cells in a dose-dependent manner (Cuca et al, 2011). Alves  et al (2023) in their bid to circumvent the hydrophobicity and thermosensitivity challenges of KA, prepared complexes of ent-kaurenoic acid-enriched Mikania glomerata leaves extract with β-cyclodextrin and assessed the antitumor activity of this formulation in rodents. The formulation displayed low systemic toxicity in mice and its antitumor activity was ascribed to its ability to inhibit LDH activity and NF-κB signaling pathway (Alves  et al, 2023).…”

“…Alves  et al (2023) in their bid to circumvent the hydrophobicity and thermosensitivity challenges of KA, prepared complexes of ent-kaurenoic acid-enriched Mikania glomerata leaves extract with β-cyclodextrin and assessed the antitumor activity of this formulation in rodents. The formulation displayed low systemic toxicity in mice and its antitumor activity was ascribed to its ability to inhibit LDH activity and NF-κB signaling pathway (Alves  et al, 2023). Antitumor activities have also been reported for microbial-derived KA derivatives against the breast cancer cell lines, MCF-7 (da Costa et al, 2018) and 4 T1 (Ferreira et al, 2022), the human glioblastoma cell line, U87 (Lizarte Neto et al, 2013) and other cell lines (Dutra et al, 2014).…”