The relative bioavailability of a single oral dose oftemafloxacin given with and without enteral feeding was determined in 18 healthy male volunteers in a randomised crossover study. Subjects were administered 600mg oftemafloxacin orally as an intact tablet, or a crushed tablet suspended in water administered through a nasogastric tube with or without an enteral feeding solution [Osmolite® (Ross) 100 ml/h started 2h before administration oftemafloxacin and continued for 4h postdosej. Plasma samples were analysed by a high performance liquia chromatographic technique. Mean peak plasma concentrations (Cmax) for the oral tablet, crushed tablet, and crushed tablet with enteral feeding solution were 3.95 ± 1.02,4.85 ± 0.69, and 4.69 ± 0.61 mgfLj70kg, respectively, and mean calculated area under the concentration-time curve from time 0 to 48h (AUC(0-48h» values were 48.1 ± 11.0, 54.5 ± 6.52, and 49.7 ± 5.89 mgfL' hj70kg, respectively. In terms of AUC(0-48h) and Cmax, the relative bioavailability of temafloxacin after nasogastric delivery of crushed temafloxacin given with and without an enteral feeding solution was equivalent to the reference oral regimen.