Neuroendocrine adenocarcinomas of the duodenum comprise a rare subset of neuroendocrine tumors and commonly present with symptoms of gastric outlet obstruction (GOO). Most of the time, patients are recommended a GI bypass in the setting of metastatic disease. In a small subset of patients who prefer a non-operative approach or are poor surgical candidates, duodenal stenting can often accomplish similar results as surgery. However, duodenal stenting is associated with numerous complications, including duodenal stent migration and, less commonly, duodenal perforation. We present a case where duodenal stenting resulted in a perforation of the second portion of the duodenum that ultimately required a definitive pancreaticoduodenectomy.