Enteric-coated capsules filled with mono-disperse micro-particles containing PLGA-lipid-PEG nanoparticles for oral delivery of insulin

VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption

“…In addition, after oral administration the insulin-loaded nanoparticles can accumulate in Peyer's patches in the intestinal tissues (Lopes et al, 2014). Surface modification of particulate drug delivery systems, such as enteric coating (Yu et al, 2015), chitosan coating (Fonte et al, 2012) and thiolated modification of carrier materials (Zhang et al, 2012) further promote the absorption of insulin in the small intestine. Therefore, submicron sized particulate carriers seem to be more suitable for delivery and increase the absorption of insulin through the intestinal membrane.…”

Enhanced oral bioavailability of insulin-loaded solid lipid nanoparticles: pharmacokinetic bioavailability of insulin-loaded solid lipid nanoparticles in diabetic rats

“…Patients with Type 1 diabetes are completely dependent on insulin injections. However, longterm insulin injections have many disadvantages like pain, allergic reactions, hyper-insulinemia and insulin lipodystrophy around the injection site (Gowthamarajan & Kulkarni, 2003;Yu et al, 2015). Fear of insulin injection is associated with poor glycemic control, clinical complications, psychological co-morbidities, poor general well-being and health status and increased risk of mortality for diabetes patients.…”

A microparticulate based formulation to protect therapeutic enzymes from proteolytic digestion: phenylalanine ammonia lyase as case study

“…Even though our strategy provided a protective effect towards trypsin digestion, further optimizations would be possibly required to prolong PAL activity during the transit in the intestinal tract. To guarantee the gastric protection of the system the particle should be loaded in enteric capsules for example in dried form 39 . However, testing these capsules in vivo would require a larger animal model than the gold standard Pah enu2/enu2 mouse model.…”