VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption

He, Huan; Wang, Puxiu; Cai, Cuifang; Yang, Rui; Tang, Xing

doi:10.1016/j.ijpharm.2015.08.004

Cited by 39 publications

(18 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the improved understanding of mucosal barrier homeostasis and recent advances in nanotechnology, technologies that safely and effectively surmount the intestinal epithelium, enabling oral delivery of complex therapeutics, are currently lacking. Transcytosis-enabled nanosystems have been proposed by several groups, including our own, for delivery of biomolecules or nanomedicines across the mucosal surfaces of the airways [6][7][8] and the intestine [9][10][11][12]. Regarding oral delivery, these strategies have demonstrated that it is feasible to transport both biotherapeutics and nanoparticles across the intestinal mucosa and into the systemic circulation after oral administration [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Intestinal Uptake and Transport of Albumin Nanoparticles: Potential for Oral Delivery

Hashem

Swedrowska

Vllasaliu

2018

Nanomedicine (Lond.)

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Intestinal Uptake and Transport of Albumin Nanoparticles: Potential for Oral Delivery

Hashem

Swedrowska

Vllasaliu

2018

Nanomedicine (Lond.)

View full text Add to dashboard Cite

show abstract

“…The electrostatic and hydrogen interactions among the excipients thus provide biohybrid systems with improved properties, such as the delivery profile of active molecules increasing plasma halflife [83], permeation [84], and efficacy [85]. Furthermore, this combination of materials can be used to modulate viscosity, consistency, and mucoadhesion of lipid nanoparticles [86] or to add thermoreversible properties to the systems [87,88].…”

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

View full text Add to dashboard Cite

The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

show abstract

“…Statistical analysis was performed using Graph Pad Prism 6 (Graph Pad software Inc.) by analysis of variance (ANOVA). The significance between treatment pairs in pharmacokinetic study was assessed using Bonferronimultiple comparison and differences were considered significant for pvalues <0.05 19 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

IJPSR

View full text Add to dashboard Cite

Present study is a systematic approach to provide "proof of concept" for effective oral delivery of Rosuvastatin lipid nanocarriers for treatment of hyperlipidemia. Rosuvastatin is a "Superstatin" belonging to BCS class II having low bioavailability (20%). Development of lipid nanocarriers for oral delivery of rosuvastatin can be beneficial in enhancing bioavailability and providing sustained release. In the current work, Rosuvastatin lipid nanocarriers were developed using Precirol® ATO 5 as lipid carrier and Tween® 80as surfactant, employing solvent emulsification-evaporation method. Investigation of effect of shear rate, solution temperature and concentration of organic solvent as process parameters were studied. Three-level two-factor(3 2 ) experimental design was applied to study the effect of lipidand surfactant on percent entrapment efficiency and particle size. Complete characterization of optimized formulation such as particle size, zeta potential, entrapment efficiency, TEM and in vitro release profile was carried out. Lipid nanocarriers exhibited mean particle size 79.31±4.82 nm, entrapment efficiency 81.29±1.11% and zeta potential -6.89±3.29 mV. In vitro diffusion of ROS from lipid nanocarriers using dialysis bag diffusion method provided pHindependent drug release. Ex vivo intestinal permeability through chick ileum revealed improvement in apparent permeability coefficient due to lipid coated nanosized particles. In vivo absorption of ROS from lipid nanocarriers resulted in about 4.41-fold increase in AUC 0-last and 8.14-fold increase in mean residence time compared to plain drug. In gist, Rosuvastatin lipid nanocarriers are advantageous in reducing dose and drug consumption, by effectively providing sustained release, which will ultimately help in minimizing dose-dependent adverse effects.

show abstract

VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption

Cited by 39 publications

References 28 publications

Intestinal Uptake and Transport of Albumin Nanoparticles: Potential for Oral Delivery

Intestinal Uptake and Transport of Albumin Nanoparticles: Potential for Oral Delivery

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Untitled

Contact Info

Product

Resources

About