Enteric coated timed release systems for colonic targeting

Wilding, Ian R.; Davis, S.S.; Pozzi, F.; Furlani, Pia; Gazzaniga, A.

doi:10.1016/0378-5173(94)90406-5

Cited by 58 publications

(25 citation statements)

References 14 publications

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“…Systems with different approaches has been reported to delay or create the lag period in drug release such as a reservoir system, surrounded by a polymeric membrane which either erodes/dissolves (Gazzaniga et al, 1994;Wilding et al, 1994) or ruptures (Krogel & Bodmeier, 1999;Bussemer et al, 2003). Several systems based on capsular drug delivery have been designed to control the lag time and/or drug release onset which delivers therapeutic agents into the body in a time-or position-controlled pulsatile release fashion.…”

Section: Introductionmentioning

confidence: 99%

Osmotically controlled pulsatile release capsule of montelukast sodium for chronotherapy: Statistical optimization,in vitroandin vivoevaluation

Ranjan¹,

Nayak²,

Reddy³

et al. 2013

Drug Delivery

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The purpose of present study was to design, optimize and evaluate osmotically controlled pulsatile release capsule (PRC) of montelukast sodium (MKS) for the prevention of episodic attack of asthma in early morning and associated allergic rhinitis. Assembly of the capsular systems consisted of push, active and plug tablet arranged from bottom to top in hard gelatin capsule. The capsule system was coated with a semi-permeable membrane of cellulose acetate and drilled towards plug side in cap. A three-factor, three-level central composite design (CCD) with ¼ 1 was introduced to execute the experiments and quadratic polynomial model was generated to predict and assess the independent variables with respect to the dependent variables. The composition of optimal formulation was determined as weight of push tablet 138 mg (coded value: þ0.59), plug tablet 60 mg (coded value: þ0.49) and coating weight gain of 8.4 mg (coded value: À0.82). The results showed that the optimal formulation of PRCs had lag time of 4.5 h, release at 6 and 12 h are 61.95% and 96.29%, respectively. The X-ray radiographic imaging study was carried out to monitor the in vivo behavior of developed barium sulfate-loaded PRCs in rabbits under fasting conditions. In vivo pharmacokinetic study revealed T max of 2 h for marketed tablets; however 7 h for PRCs with initial lag time of 4 h. Thus designed capsular system may be helpful for patients with episodic attack of asthma in early morning and associated allergic rhinitis.

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Section: Introductionmentioning

confidence: 99%

Osmotically controlled pulsatile release capsule of montelukast sodium for chronotherapy: Statistical optimization,in vitroandin vivoevaluation

Ranjan¹,

Nayak²,

Reddy³

et al. 2013

Drug Delivery

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“…5. Where V t is the volume (cm 3 ) of the tablet and ρs is the particle density (g/cm 3 ) of the solid material. A plot ln (1/1-D) versus applied pressure (P) which corresponds to the Heckle plots were then made for MCC and the different MCC motifs.…”

Section: Heckle Modelmentioning

confidence: 99%

“…These have contributed to the pressure to develop new excipients especially those with multifunctional properties to reduce final cost of production and also meet the increasing need for emerging new drug delivery technology [1][2][3]. In modern drug production technology the availability of excipients with innovative physicochemical and functional properties is as critical as the invention of new formulation techniques.…”

Section: Introductionmentioning

confidence: 99%

Impact of Co-Processing on Some Fundamental Physicochem

Builders¹

2013

IOSR-JPBS

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“…The time lag depends on the thickness of the coating layer [46]. The Time Clock® system consists of a solid dosage form coated with lipid barriers containing carnauba wax and bees wax along with surfactants, such as polyoxyethylene sorbitan monooleate [47,48]. This coat erodes or emulsifies in the aqueous environment in a time proportional to the thickness of the film, and the core is then available for dispersion.…”

Section: Iiport Systemsmentioning

confidence: 99%

Recent trends in pulsatile drug delivery systems - A review.

Sharma¹,

Srikanth²,

Uhumwangho³

et al. 2010

Int j Drug delivery

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The purpose of writing this review on pulsatile drug delivery systems (PDDS) is to compile the recent literatures with special focus on the different types and approaches involved in the development of the formulation. PDDS are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site. Some of the disease conditions wherein PDDS are promising include duodenal ulcer, cardiovascular diseases, arthritis, asthma, diabetes, neurological disorder, cancer, hypertension and hypercholesterolemia. PDDS can be classified into time controlled systems wherein the drug release is controlled primarily by the delivery system, stimuli induced PDDS in which release is controlled by the stimuli, such as the pH or enzymes present in the intestinal tract or enzymes present in the drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. This review also summarizes some current PDDS already available in the market. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

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Enteric coated timed release systems for colonic targeting

Cited by 58 publications

References 14 publications

Osmotically controlled pulsatile release capsule of montelukast sodium for chronotherapy: Statistical optimization,in vitroandin vivoevaluation

Osmotically controlled pulsatile release capsule of montelukast sodium for chronotherapy: Statistical optimization,in vitroandin vivoevaluation

Impact of Co-Processing on Some Fundamental Physicochem

Recent trends in pulsatile drug delivery systems - A review.

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