Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs

Morishita, Shinya; Kawaguchi, Hiroaki; Ono, Tetsuya; Miura, Naoki; Murakoshi, Michiaki; Sugiyama, Kazunari; Kato, Harubumi; Tanimoto, Akihide; Nishino, Hoyoku

doi:10.1080/09168451.2015.1091713

Cited by 25 publications

(7 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, significant additive interactions between famine exposure and the high-fat and high-salt dietary pattern on the risk of diabetes and hypercholesterolaemia were found. Morishita et al reported that highfat diet behaviour could form atherosclerotic plaque and block blood vessels by damaging vascular endothelium and, thereafter, contribute to hypertension and other cardiovascular and cerebrovascular diseases by lumen narrowing (36) . In addition, high-salt diets can promote body fluid volume expansion, adrenal cortical production and release of sodium pump inhibitor increasing through inhibiting the cell membrane Na + 2K + 2ATP enzyme activity, which could contribute to blood pressure elevation and dyslipidaemia (37) .…”

Section: Main Findingsmentioning

confidence: 99%

The effect of Chinese famine exposure in early life on dietary patterns and chronic diseases of adults

Zhou

Sheng

Fan

et al. 2018

Public Health Nutr.

View full text Add to dashboard Cite

ObjectiveTo assess the effect of famine exposure during early life on dietary patterns, chronic diseases, and the interaction effect between famine exposure and dietary patterns on chronic diseases in adulthood.DesignCross-sectional study. Dietary patterns were derived by factor analysis. Multivariate quantile regression and log-binomial regression were used to evaluate the impact of famine exposure on dietary patterns, chronic diseases and the interaction effect between famine exposure and dietary patterns on chronic diseases, respectively.SettingHefei, China.ParticipantsAdults aged 45–60 years (n 939).Results‘Healthy’, ‘high-fat and high-salt’, ‘Western’ and ‘traditional Chinese’ dietary patterns were identified. Early-childhood and mid-childhood famine exposure were remarkably correlated with high intake of the traditional Chinese dietary pattern. Compared with the non-exposed group (prevalence ratio (PR); 95 % CI), early-childhood (3·13; 1·43, 6·84) and mid-childhood (2·37; 1·05, 5·36) exposed groups showed an increased PR for diabetes, and the early-childhood (2·07; 1·01, 4·25) exposed group showed an increased PR for hypercholesterolaemia. Additionally, relative to the combination of non-exposed group and low-dichotomous high-fat and high-salt dietary pattern, the combination of famine exposure in early life and high-dichotomous high-fat and high-salt dietary pattern in adulthood had higher PR for diabetes (4·95; 1·66, 9·05) and hypercholesterolaemia (3·71; 1·73, 7·60), and significant additive interactions were observed.ConclusionsHaving suffered the Chinese famine in childhood might affect an individual’s dietary habits and health status, and the joint effect between famine and harmful dietary pattern could have serious consequences on later-life health outcomes.

show abstract

Section: Main Findingsmentioning

confidence: 99%

The effect of Chinese famine exposure in early life on dietary patterns and chronic diseases of adults

Zhou

Sheng

Fan

et al. 2018

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…Lactoferrin receptors (low-density lipoprotein receptor-related protein 1 and 2, intelectin 1 and nucleolin) are localised on a variety of cells such as monocytes, lymphocytes, adipocytes, hepatocytes and endothelial cells [4]. So far, multiple activities of lactoferrin have been shown in both preclinical [5,6,7] and clinical studies [8,9]. It was documented that lactoferrin possesses anti-inflammatory, antibacterial, antiviral, immunomodulatory, antioxidant, and anticancer activities [4].…”

Section: Introductionmentioning

confidence: 99%

No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women

Jamka

Krzyżanowska-Jankowska

Mądry

et al. 2019

Nutrients

View full text Add to dashboard Cite

Background: The aim of the study was to compare serum lactoferrin concentrations in metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) women. Methods: Three hundred (101 MHO and 199 MUHO) women were recruited to the study. Basic anthropometric parameters and blood pressure were measured. Body mass index (BMI) was calculated. Fat mass and visceral adipose tissue mass were assessed using dual X-ray absorptiometry scan. Fasting glucose, insulin, lipid profile, high sensitivity C-reactive protein (hs-CRP) and lactoferrin levels were determined. Results: Lactoferrin levels did not differ between MHO and MUHO subjects (median (interquartile range): 1639 (1055–2396) vs. 1622 (1009–23345) ng/mL). However, in the total population insulin (r = 0.131, p = 0.0234) and hs-CRP (r = 0.165, p = 0.0045) levels were correlated with lactoferrin concentrations. In addition, a weak positive association between serum lactoferrin concentrations and anthropometric parameters was also detected, and predominantly referred to MHO group (body weight: r = 0.231, p = 0.0201; BMI: r = 0.286, p = 0.0037; waist circumference: r = 0.258, p = 0.0092). In addition, serum lactoferrin concentrations were negatively correlated with fasting glucose (r = −0.250, p = 0.0115) and HDL-C levels (r = −0.203, p = 0.0411) in MHO subjects. Conclusions: Lactoferrin levels did not differ between MHO and MUHO women. However, some mild correlations between lactoferrin concentrations and anthropometric and metabolic parameters were observed mostly in MHO subjects.

show abstract

“… Biological functions of bioactive milk osteopontin. Related references cited in the Figure: ( a: [ 125 , 126 ]; b : [ 127 ]; c : [ 128 ]; d : [ 129 ]; e : [ 130 , 131 , 132 ]; f : [ 133 ]; g : [ 134 ]; h : [ 135 ]; i : [ 136 ]; j : [ 137 ]; k : [ 138 ]; l : [ 139 , 140 ]; m : [ 141 ]; n : [ 142 ]; o : [ 143 ]; p : [ 144 ]; q : [ 145 ]; r : [ 146 ]; s : [ 147 ]; t : [ 148 , 149 ]; u : [ 150 ]). …”

Section: Figureunclassified

Lactoferrin, Osteopontin and Lactoferrin–Osteopontin Complex: A Critical Look on Their Role in Perinatal Period and Cardiometabolic Disorders

et al. 2023

View full text Add to dashboard Cite

Milk-derived bioactive proteins have increasingly gained attention and consideration throughout the world due to their high-quality amino acids and multiple health-promoting attributes. Apparently, being at the forefront of functional foods, these bioactive proteins are also suggested as potential alternatives for the management of various complex diseases. In this review, we will focus on lactoferrin (LF) and osteopontin (OPN), two multifunctional dairy proteins, as well as to their naturally occurring bioactive LF–OPN complex. While describing their wide variety of physiological, biochemical, and nutritional functionalities, we will emphasize their specific roles in the perinatal period. Afterwards, we will evaluate their ability to control oxidative stress, inflammation, gut mucosal barrier, and intestinal microbiota in link with cardiometabolic disorders (CMD) (obesity, insulin resistance, dyslipidemia, and hypertension) and associated complications (diabetes and atherosclerosis). This review will not only attempt to highlight the mechanisms of action, but it will critically discuss the potential therapeutic applications of the underlined bioactive proteins in CMD.

show abstract

Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs

Cited by 25 publications

References 39 publications

The effect of Chinese famine exposure in early life on dietary patterns and chronic diseases of adults

The effect of Chinese famine exposure in early life on dietary patterns and chronic diseases of adults

No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women

Lactoferrin, Osteopontin and Lactoferrin–Osteopontin Complex: A Critical Look on Their Role in Perinatal Period and Cardiometabolic Disorders

Contact Info

Product

Resources

About