2015
DOI: 10.1016/j.cyto.2015.06.007
|View full text |Cite
|
Sign up to set email alerts
|

Enteric nematodes and the path to up-regulation of type 2 cytokines IL-4 and IL-13

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
13
0

Year Published

2015
2015
2021
2021

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 16 publications
(14 citation statements)
references
References 93 publications
(123 reference statements)
0
13
0
Order By: Relevance
“…Intestinal nematodes are among the most common and widely distributed animal parasites of humans, estimated to infect over 2.5 billion of the world's population, the majority of infections occurring in children 1, 2. Among the most prevalent intestinal worms are the hookworm ( Ancylostoma duodenale and Necator americanus ), roundworm ( Ascaris lumbricoides ) and whipworm ( Trichuris trichiura ) , which are typically found endemic in developing and tropical countries.…”
Section: Introductionmentioning
confidence: 99%
“…Intestinal nematodes are among the most common and widely distributed animal parasites of humans, estimated to infect over 2.5 billion of the world's population, the majority of infections occurring in children 1, 2. Among the most prevalent intestinal worms are the hookworm ( Ancylostoma duodenale and Necator americanus ), roundworm ( Ascaris lumbricoides ) and whipworm ( Trichuris trichiura ) , which are typically found endemic in developing and tropical countries.…”
Section: Introductionmentioning
confidence: 99%
“…Whether the sole lack of IL-4/IL-13 responsiveness on enteric nerves in an otherwise immunocompetent host would impair worm expulsion has not been determined. Even so, there is published evidence for STAT6-responsive enteric nerve receptors such as protease-activated receptors 1 and 2, muscarinic 3 receptor, 36 while immune cells including macrophages and T cells produce and respond to adrenaline and acetylcholine. 37 Combined, these data are entirely consistent with the rapidly emerging field of neuroimmunology, which is predicated on data showing that communication between neuronal networks and the immune system has a broad impact upon the outcome of host-pathogen interactions.…”
Section: Th2 Cytokinesmentioning
confidence: 99%
“…In the case of GINs, innate immunity includes responses from cells in the epithelium of the GIT, including goblet cells that produce mucus, as well as innate lymphoid cells that produce type 2 cytokines (IL‐4, IL‐5, IL‐13, etc.). The mucin layer covering the luminal surface of the GIT acts as a physical barrier to GIN establishment and promotes worm expulsion . Parasite infection triggers goblet cell hyperplasia, changes the composition and volume of mucus, and upregulates goblet cell‐associated effector molecules, in particular MUC2 and MUC5AC .…”
Section: Phenotypic Markers Of Resistance To Gin Infectionmentioning
confidence: 99%
“…Similar temporal differences in the expression of the Th1/Th2/Treg immune response have been observed between Scottish Blackface sheep selected for either high or low FEC and between Suffolk sheep with or without the allele Ovar‐DRB1*1101, which has been associated with resistance. Th2 cells typically produce the cytokine panel IL‐4, IL‐5, IL‐9, IL‐13, IL‐25 and IL33 . IL‐4 suppresses the development of Th1 and Th17 subsets, while concurrently driving the Th2 response.…”
Section: Phenotypic Markers Of Resistance To Gin Infectionmentioning
confidence: 99%
See 1 more Smart Citation