1985
DOI: 10.1016/0016-5085(85)90195-7
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Enteric nerves in diabetic rats: Increase in vasoactive intestinal polypeptide but not substance P

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Cited by 121 publications
(57 citation statements)
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“…The diabetes-induced changes in NA-, NOS-, VIP-, and CGRP-containing nerves supplying the ileum were similar to those reported previously (22,40,41). There is evidence that VIP-and NA-containing nerves are degenerating at this stage, whereas changes in CGRP-containing nerves reflect loss of neurotransmitter expression rather than nerve fiber loss (4,5,42,43).…”
Section: Diabetic Autonomic Neuropathy Preventionsupporting
confidence: 89%
“…The diabetes-induced changes in NA-, NOS-, VIP-, and CGRP-containing nerves supplying the ileum were similar to those reported previously (22,40,41). There is evidence that VIP-and NA-containing nerves are degenerating at this stage, whereas changes in CGRP-containing nerves reflect loss of neurotransmitter expression rather than nerve fiber loss (4,5,42,43).…”
Section: Diabetic Autonomic Neuropathy Preventionsupporting
confidence: 89%
“…Of these, enteric neuropathy may be particularly important (5,6,48). Several studies of animal models of diabetes have convincingly shown disturbances in enteric nerves, particularly involving nitrergic nerves (14,49,52).…”
Section: Discussionmentioning
confidence: 99%
“…Systematization of the studies on the enteric neurons, especially those of the myenteric plexus of species such as the rat, mouse and guinea-pig, have permitted to determine, with relative precision, the functions of specific groups of neurons [7][8][9] . Due to the accessibility of the ENS, investigations about the alterations caused by pathophysiological states, such as diabetes, have been equally productive; there are reports on the literature [10][11][12][13] about the differential effects of diabetes on specific neurotransmitter systems and on neurons of diverse intestinal segments.…”
Section: Palavras-chave: Duodeno Neurônios Mientéricos Diabetes Agumentioning
confidence: 99%