Entering the second decade: <i>FEBS Open Bio</i> in 2022

Wright, Duncan E.; Rosa, Miguel A. De la

doi:10.1002/2211-5463.13343

Cited by 2 publications

(1 citation statement)

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“…It is possible that even within a single disease process, there are many forms of dysbiosis, a concept that has previously been referred to as the 'Anna Karenina principle' about Tolstoy's writings that "happy families are all alike; every unhappy family is unhappy in its way" [13]. The lung microbiome differs between patients with DM and RA associated with ILD [25]. In the present study, Streptococcus was high in subjects with IPF compared to HP and unclassifiable ILD, and Staphylococcus was found in relatively equal proportions in the three cohorts.…”

Section: Discussionmentioning

confidence: 99%

Lung Microbiota in Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis, and Unclassified Interstitial Lung Diseases: A Preliminary Pilot Study

Man,

Ungur,

Motoc

et al. 2023

Diagnostics

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(1) Introduction: Although historically, the lung has been considered a sterile organ, recent studies through 16S rRNA gene sequencing have identified a substantial number of microorganisms. The human microbiome has been considered an “essential organ,” carrying about 150 times more information (genes) than are found in the entire human genome. The purpose of the present study is to characterize and compare the microbiome in three different interstitial lung diseases: idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis, and nondifferential interstitial lung disease. (2) Material and methods: This was a prospective cohort study where the DNA of 28 patients with ILD was extracted from the lavage and then processed using the standard technique of 16S RNA gene sequencing. In a tertiary teaching hospital in the northern, western part of Romania, samples were collected through bronchoscopy and then processed. (3) Results: The same four species were found in all the patients but in different quantities and compositions: Firmicutes, Actinobacteria, Proteobacteria and Bacteroides. Streptococcus was the most prevalent genus, followed by Staphylococcus and Prevotella. Statistically significant differences in the OUT count for the ten most abundant taxa were found for the genus: Gemella, Actinobacteria, Prevotella, Neisseria, Haemophilus, and Bifidobacterium. The comparative analysis showed a richer microbiota in patients with IPF, as shown by the alpha diversity index. (4) Conclusions: In interstitial lung diseases, the microorganisms normally found in the lung are reduced to a restricted flora dominated by the Firmicutes family. These changes significantly disrupt the continuity of the observed bacterial pattern from the oropharynx to the bronchial tree and lung, possibly impacting the evolution and severity of interstitial lung diseases.

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Section: Discussionmentioning

confidence: 99%