Enterochromaffin cells in the duodenal mucosa of children with coeliac disease.

Challacombe, D N; Robertson, K

doi:10.1136/gut.18.5.373

Cited by 36 publications

(7 citation statements)

References 16 publications

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“…Thus Polak and co-workers (1973) found an increased number of secretin immunoreactive cells in children with this disease. Results have also been presented indicating a greater number of enterochromaffin cells (Challacombe and Robertson, 1977) and raised 5-HT concentration in the duodenal mucosa of such children.…”

mentioning

confidence: 93%

Duodenal endocrine cells in adult coeliac disease.

Sjölund¹,

Alumets²,

Berg³

et al. 1979

Gut

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SUMMARY Using immunohistochemical techniques we studied duodenal biopsies from 18 patients with coeliac disease and 24 patients with normal duodenal morphology. We had access to antisera against the following gastrointestinal peptides: cholecystokinin (CCK), gastric inhibitory peptide (GIP), gastrin-17, glucagon-enteroglucagon, motilin, neurotensin, pancreatic peptide (PP), secretin, somatostatin, substance P, and vasoactive intestinal peptide (VIP). The somatostatin, GIP, CCK, and glucagon cells were increased in number in coeliac disease. The number of motilin cells was slightly increased, while secretin cells were reduced. Cells storing gastrin-17, substance P, or neurotensin were rare in all patients regardless of diagnosis. No PP immunoreactive cells were found and VIP was localised to neurons only. In biopsies from patients having a mucosa with ridging of villi the number of the various endocrine cell types did not differ from that in the control group.

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mentioning

confidence: 93%

Duodenal endocrine cells in adult coeliac disease.

Sjölund¹,

Alumets²,

Berg³

et al. 1979

Gut

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“…Although mean 5-HT concentrations were greater in the post-challenge biopsies than in the controls, levels did not attain the values found in patients with coeliac disease who had unequivocal histopathological changes in their duodenal biopsies. (Challacombe and Robertson, 1976). In the present study increased tissue concentrations of 5-HT were found in the duodenal mucosa of adults and children with coeliac disease.…”

Section: Resultsmentioning

confidence: 99%

“…Raised blood levels of 5-HT in coeliac disease (Pimparker et al, 1961;Warner and Cohen, 1962) also return to normal after gluten withdrawal from the diet. 5-HT is synthesised in the small intestine by enterochromaffin (EC) cells, and hyperplasia of these cells has been reported in patients with coeliac disease (Challacombe and Robertson, 1976). In the present investigation, tissue levels of 5-HT were estimated in the duodenal mucosa of adults and children with coeliac disease and the results compared with a group of controls.…”

mentioning

confidence: 86%

Increased tissue concentrations of 5-hydroxytryptamine in the duodenal mucosa of patients with coeliac disease.

Challacombe¹,

Dawkins²,

Baker³

1977

Gut

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SUMMARY Tissue concentrations of 5-HT have been measured in the duodenal mucosa of adults and children with coeliac disease and were found to be significantly higher than those from a control group. This finding may be associated with hyperactivity or hyperplasia of enterochromaffin (EC) cells in the duodenum of patients with coeliac disease and could also be directly related to described abnormalities of 5-HT metabolism in this disease.

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“…A markedly increased number of enterochromaffin cells has previously been found in the intestinal wall of patients with celiac disease [23,24]. Furthermore, a patient with celiac disease who developed a metastasizing ileal carcinoid was described by Hallert and Norrby [25], and an ongoing project shows that 60% of patients with midgut carcinoids are HLA DQ2-positive, indicating a hereditary risk for celiac disease.…”

Section: Discussionmentioning

confidence: 99%

First Report on Metastasizing Small Bowel Carcinoids in First-Degree Relatives in Three Generations

Järhult¹,

Landerholm²,

Falkmer

et al. 2010

Neuroendocrinology

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Background/Aims: There is an established association between the multiple endocrine neoplasia type 1 (MEN 1) syndrome and foregut carcinoids. Some registry studies also indicate that offspring to carcinoid patients run an increased risk of developing a carcinoid tumor themselves. However, there are only scattered reports of gastrointestinal carcinoids in two generations. The aim of this study was to describe the clinical characteristics as well as the histopathological, immunohistochemical (IHC) and genetic data of metastasizing ileal carcinoids in three consecutive first-degree relatives. Methods: The histopathological and IHC analyses were performed on newly cut sections of the tumor specimens and included growth pattern, proliferation index (Ki-67) as well as expression of established neuroendocrine markers and recently introduced cocaine-amphetamine-regulated transcript (CART). The genetic analyses were focused on establishing whether a connection with the MEN 1 syndrome existed in this family, by means of mutation screening using polymerase chain reaction, multiple ligation-dependent probe amplification, and genotyping using fluorescent-labeled microsatellite markers. Results: Histopathology and IHC revealed that the tumors were virtually identical, with only minor differences in proliferation index and expression of CART. Genetic analyses indicated that the inheritance of the small bowel carcinoids in the family was not linked to the MEN1 gene. Conclusion: Metastasizing small bowel carcinoids have been found in first-degree relatives in three consecutive generations. All three tumors were very similar when characterized by histopathology and IHC. Based on clinical findings and genetic analyses, it seems unlikely, although not completely excluded, that inheritance was linked to the MEN 1 syndrome.

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Enterochromaffin cells in the duodenal mucosa of children with coeliac disease.

Cited by 36 publications

References 16 publications

Duodenal endocrine cells in adult coeliac disease.

Duodenal endocrine cells in adult coeliac disease.

Increased tissue concentrations of 5-hydroxytryptamine in the duodenal mucosa of patients with coeliac disease.

First Report on Metastasizing Small Bowel Carcinoids in First-Degree Relatives in Three Generations

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