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The present invention relates to therapeutic uses of clen buterol in humans and animals. The uses include retarding or reversing muscular atrophy of denervated muscle, alleviat ing or reversing loss of function arising from surgical or accidental muscular trauma, and alleviating or reversing the loss of muscle function arising from a humorally mediated catabolic state or from temporary disuse of the muscle. Clenbuterol can be mixed with a beta-adrenergic antagonist to obviate or mitigate unwanted side effects without exces sively inhibiting the desired therapeutic effects."Modification of body composition by clenbuterol in normal and dystrophic (mdx) mice," by N. J. Rothwell and M. J. Stock, Bioscience Reports 5, pp. 755-760 (1985)."Chronic effects of B-adrenergic agonists on body compo sition and protein synthesis in the rat,' by P. W. Emery, N.

Clenbuterol [benzyl alcohol, 4-amino-alpha-(t-butylamino)methyl-3,5-dichloro] was tested in the finisher ration of broilers in three series of experiments for its effects on performance and carcass characteristics. In Experiment 1, administration of clenbuterol at feed levels of .25, .5, 1, 2, and 4 ppm from 28 to 49 days of age resulted in significant sex combined weight gain improvements at all levels except 4 ppm and significant feed efficiency improvements at all levels tested. Uneviscerated body composition analysis indicated that clenbuterol treatment significantly increased body protein and water content and decreased body fat in female birds. In males, body fat was significantly reduced by 1, 2, and 4 ppm clenbuterol. From these results the 1 ppm level was selected for further testing. In Experiments 2 and 3, clenbuterol fed from 28 to 49 days of age significantly improved sex combined weight gain and feed efficiency and both male and female 49-day weights. Carcass yield was significantly increased in males and females by 1.11 and 1.91 percentage points, respectively. Abdominal fat was significantly reduced by clenbuterol feeding only in females. Carcass analysis indicated that clenbuterol-fed birds had a significantly lower carcass fat content. In Experiments 4 to 7, clenbuterol was administered at 1 ppm in the finishing feed but was withdrawn 3 to 5 days prior to terminal performance and carcass evaluations. Clenbuterol significantly improved sex combined weight gain and feed efficiency, and 49-day weights for both sexes. Carcass yield was significantly increased in males and females by .54 and .98 percentage points, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

SUMMARY Tissue concentrations of 5-HT have been measured in the duodenal mucosa of adults and children with coeliac disease and were found to be significantly higher than those from a control group. This finding may be associated with hyperactivity or hyperplasia of enterochromaffin (EC) cells in the duodenum of patients with coeliac disease and could also be directly related to described abnormalities of 5-HT metabolism in this disease.

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