Repartitioning Agents: 5-[1-Hydroxy-2-(isopropylamino)ethyl]-anthranilonitrile and Related Phenethanolamines; Agents for Promoting Growth, Increasing Muscle Accretion and Reducing Fat Deposition in Meat-producing Animals

Asato, Goro; Baker, P.K.; Bass, Roy T.; Bentley, T. J.; Chari, Sarangan; Dalrymple, R. H.; France, Donald J.; Gingher, Paul E.; Lences, Barbara L.; Pascavage, John J.; Pensack, J. M.; Ricks, Catherine A.

doi:10.1080/00021369.1984.10866611

Cited by 10 publications

(11 citation statements)

References 2 publications

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“…The level of cimaterol provided in the feed was selected on the basis of results from Asato et al (1984), which suggested .25 ppm was the optimum level for use with broilers. There were no significant differences between live weights of the two treatment groups at any age.…”

Section: Discussionmentioning

confidence: 99%

“…Dietary clenbuterol significantly reduced eviscerated carcass fat in both males and females, but only in the female was abdominal fat reduced. Asato et al (1984) assessed the growth-promoting and fat-reducing potencies of a series of phenethanolamines related to clenbuterol. In chickens, 5-[l-hydroxy-2-(isopropylamino)ethyl]anthranilonitrile (cimaterol) appeared to be more potent than clenbuterol in its ability to redirect metabolized energy away from fat formation and toward muscle accretion.…”

Section: Introductionmentioning

confidence: 99%

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Adipose Tissue Deposition and Cellularity in Cimaterol-Treated Female Broilers

Merkley

Cartwright

1989

Poultry Science

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The effect of feeding a beta agonist, cimaterol, on carcass yield and composition and adipose tissue development was studied in female broilers. Cimaterol was provided at .25 ppm in the feed starting at 4 wk of age. Birds were sacrificed at 4, 6, 8, 10, 12, and 16 wk for determination of eviscerated carcass yield, carcass composition, and growth and cellularity of the abdominal, neck, back, and sartorial adipose depots. Carcass yield was significantly (P less than .01) greater in treated birds than in controls (70.0 vs. 72.8%) at 10 wk of age. Moisture percentage and protein decreased (P less than .05) less rapidly in treated carcasses than in control carcasses with increasing age. Lipid percentage increased (P less than .05) in treated carcasses less rapidly than in control carcasses. The weight of the abdominal fat pad was significantly (P less than .05) lower in treated birds than controls at 16 wk. There were no significant treatment effects on live weights, skeletal growth, or liver weights at any age. The composition of the pectoralis minor was not affected by the treatment. Frequency distributions of adipocyte diameters from the neck and thigh differed from those of the abdominal and back depots at 16 wk. Adipocyte diameter appeared to be more sensitive to the dietary treatment than adipocyte numbers per depot. Both adipocyte size and numbers in each depot continued to increase with increasing age of the broilers. The abdominal fat pad showed the largest percentage increase in cell numbers from 4 to 16 wk of age.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adipose Tissue Deposition and Cellularity in Cimaterol-Treated Female Broilers

Merkley

Cartwright

1989

Poultry Science

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“…Oral or parenteral administration of substituted phenylethanolarnines, which share some structural and pharmacological properties with the naturally occurring catecholamines epinephrine and norepinephrine, has been found to have profound effects on skeletal muscle growth and fat deposition in farm animals (Asato, 1984;Baker and Kiernan, 1983). The first reports of the repartitioning of tissue growth by this type of compound centered on the effects of clenbuterol in lambs (Baker et ai., 1984), poultry (Dalrymple et ai., 1984a), cattle and swine .…”

Section: Use Of F3-adrenergic Agonists To Manipulate Animal Growthmentioning

confidence: 99%

Animal Growth Regulation

1989

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“…Asato et al (1984) have been investigating the effect of ß-agonists on fat deposition in a number of farm animals, including poultry. Initially these were produced as human anti-obesity drugs but are now being tested on farm animals.…”

Section: Regulation Of Lipolysis and Its Role In Hypertrophymentioning

confidence: 99%