Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation

Oliveira-Santos, Alécia A; Salvatori, Roberto; Nogueira, Mônica Cristina; Bueno, Ana Carolina; Barros-Oliveira, Cynthia S; Leal, Ângela Cristina Gomes Borges; Marinho, Cindi G.; Damascena, Nicole Prata; Oliveira, D A S; Melo, Manuela A; Oliveira, Carla R. P.; Costa, F.; Santos, Jinssica S.S. Dos; Santos, Paula Fc; Campos, Viviane C.; Santos, Elenilde G.; Melo, Enaldo Vieira de; Barbosa, Meirielly L.A.; Rocha, Ívina E. S.; Castro, Margaret de; Aguiar‐Oliveira, Manuel H.

doi:10.1210/jc.2019-00094

Cited by 9 publications

(9 citation statements)

References 54 publications

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“…As ghrelin is a potent GLP-1 secretion enhancer, they speculated that high ghrelin secretion causes higher GLP-1 secretion, thereby contributing to the increased insulin sensitivity of subjects with IGHD. Additionally, the reduction in the somatostatin tone can contribute to the increase in GLP-1 in view of the feedback loop between GLP-1 and somatostatin [96,97]. Therefore, the authors' results confirmed the existence of the mutual relationship between ghrelin, insulin/glucagon and GLP-1/GHIH.…”

Section: The Influence Of Malnutrition On Ghrelin Secretionsupporting

confidence: 60%

“…We proposed a tempting hypothesis that the low bioactivity of IGF-1 is a stimulating factor for ghrelin synthesis [63,64]. An interesting analysis was described by Oliviera-Santos et al [96]. Authors calculated the area under the curve (AUC) of ghrelin in response to a mixed meal in a cohort of 20 adults with congenital, untreated, severe isolated GHD caused by homozygous mutation in the GHRHR gene (c.57+1 G→A) and in controls.…”

Section: The Influence Of Malnutrition On Ghrelin Secretionmentioning

confidence: 99%

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Contribution of Ghrelin to the Pathogenesis of Growth Hormone Deficiency

Lewiński

Karbownik-Lewińska

Wieczorek-Szukała

et al. 2021

IJMS

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In this review we described the interactions between ghrelin and the growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in children and adults with growth hormone deficiency (GHD). A possible involvement of these interactions in the pathogenesis of unexplained cases of GHD was suggested. Current research provides more and more details to the knowledge on the circadian rhythm of ghrelin. We gathered reports on the decreasing effect of Helicobacter pylori-related chronic gastritis on the number of ghrelin immunopositive cells and the consequent decrease in ghrelin serum concentration. The gastrointestinal tract microflora modification of the ghrelin action, by the mechanism of molecular mimicry, was also stressed. Moreover, the mutual relationships between ghrelin and the TSH-FT4/FT3 axis in growth and metabolic processes are described. It is to be recalled that FT4 and FT3 exert a permissive impact on IGF-1 action and, in turn, GH, in reaction mediated by IGF-1, enhances the monodeiodination of FT4 to FT3. Finally, we discussed the latest attempts to use the GH secretagogue receptor (GHS-R) analogues for possible diagnostic and therapeutic purposes.

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Section: The Influence Of Malnutrition On Ghrelin Secretionsupporting

confidence: 60%

Section: The Influence Of Malnutrition On Ghrelin Secretionmentioning

confidence: 99%

Contribution of Ghrelin to the Pathogenesis of Growth Hormone Deficiency

Lewiński

Karbownik-Lewińska

Wieczorek-Szukała

et al. 2021

IJMS

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“…Low circulating des-acyl ghrelin levels increase cardiovascular risk ( 53 ). However, Oliveira-Santos et al ( 54 ) argued that there are favorable vascular and metabolic outcomes of reduced postprandial ghrelin secretion in GHD individuals. In our cohort, GHD children treated with rhGH showed higher total ghrelin and lower resistin levels than the control group.…”

Section: Discussionmentioning

confidence: 99%

Increased Carotid Intima-media Thickness and Its Association with Carbohydrate Metabolism and Adipocytokines in Children Treated with Recombinant Growth Hormone

Saygılı¹,

Kocaaga²,

Kaya³

et al. 2023

Jcrpe

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Objective: Reports on the association between growth hormone (GH) therapy and cardiovascular risk factors in children are limited. This study aimed to evaluate carotid intima-media thickness (cIMT) in children treated with recombinant human GH (rhGH) and assess the effects of rhGH therapy and changes in serum carbohydrate metabolism, lipid profile and adipocytokines on cIMT. Methods: Seventy-one isolated idiopathic GH deficiency (GHD) children and 44 age- and sex-matched healthy controls were enrolled in this study. The study group was divided into two subgroups according to insulin resistance (IR) on oral glucose tolerance tests. Insulin secretion [homeostatic model assessment (HOMA) B, total insulin] and sensitivity (HOMA-IR, QUICKI, Matsuda) indices were calculated. cIMT was measured and the standard deviation scores (SDS) were calculated. Associations between cIMT-SDS and insulin secretion and sensitivity indices, serum lipid levels, adipocytokines (leptin, resistin, ghrelin), and other rhGH treatment-related factors were evaluated. Results: cIMT-SDS was increased in GHD children treated with rhGH compared to the controls [0.02 (2.27) vs. -1.01 (1.63), p=0.003]. cIMT-SDS did not differ between those children on rhGH treatment with or without IR. High cIMT-SDS was significantly associated with higher serum ghrelin levels and lower serum high density lipoprotein (HDL) levels (β=0.491, p=0.001 and β=-0.027, p=0.017), but not with BMI-SDS, blood pressure, insulin secretion and sensitivity indices, or the dose and duration of rhGH therapy. Conclusion: Our findings showed that GHD children treated with rhGH have increased cIMT. Alterations in carbohydrate metabolism were not associated with cIMT in children treated with rhGH. GH therapy per se appears to be associated with this increased cIMT but causality should be elucidated in further studies. cIMT also appears to be associated with higher ghrelin and lower HDL levels.

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“…In addition, they consume, in percentage, more proteins, less carbohydrates, and equal amounts of lipids ( 58 ). They show increased areas under the curves of GLP-1 and ghrelin and hunger attenuation in response to a mixed meal ( 59 ). They also exhibit reduced FGF21 and β-Klotho levels.…”

Section: Body Functions In Itabaianinha Syndromementioning

confidence: 99%

The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

Aguiar‐Oliveira¹,

Salvatori²

2022

Archives of Endocrinology and Metabolism

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In the late 19 th century, José Dantas de Souza Leite, a physician born in Sergipe, published the first detailed clinical description of acromegaly under the guidance of the French neurologist Pierre Marie. In 2014, the Brazilian Society of Endocrinology and Metabolism created the "José Dantas de Souza Leite Award" , which is granted every two years to a Brazilian researcher who has contributed to the development of endocrinology. In 2022, the award was given to another physician from Sergipe, Manuel Hermínio de Aguiar Oliveira, from the Federal University of Sergipe for the description of "Itabaianinha syndrome" in a cohort of individuals with isolated GH deficiency due to a homozygous inactivating mutation in the GH-releasing hormone receptor gene. This research, which was carried out over almost 30 years, was performed in partnership with Roberto Salvatori from Johns Hopkins University and in collaboration with other researchers around the world. This review article tells the story of Souza Leite, some milestones in the history of GH, and summarizes the description of Itabaianinha syndrome.

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Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation

Cited by 9 publications

References 54 publications

Contribution of Ghrelin to the Pathogenesis of Growth Hormone Deficiency

Contribution of Ghrelin to the Pathogenesis of Growth Hormone Deficiency

Increased Carotid Intima-media Thickness and Its Association with Carbohydrate Metabolism and Adipocytokines in Children Treated with Recombinant Growth Hormone

The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

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