Enterokinase in Contaminated Small-Bowel Syndrome

Rutgeerts, L; Mainguet, P.; Tytgat, G. N. J.; Eggermont, Ephrem

doi:10.1159/000197543

Cited by 24 publications

(6 citation statements)

References 6 publications

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“…16,38 The reason for this is possibly attributable to bacterial-induced mucosal damage leading to malabsorption of dietary proteins that rely on membrane hydrolysis. 39,40 Alternatively, bacteria in the small intestines may be inducing some degree of intestinal inflammation, leading to increased permeability of intestinal vasculature or lymphatics with subsequent protein (albumin) exudation across the mucosal surface and mild subclinical protein-losing enteropathy. It is interesting that only albumin concentration, but not globulin concentration, was significantly affected in our study.…”

Section: Discussionmentioning

confidence: 99%

Effects of oral administration of metronidazole on small intestinal bacteria and nutrients of cats

Johnston

Lamport²,

Ballèvre³

et al. 2000

ajvr

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Oral administration of metronidazole decreased the number of aerobic bacteria and altered indigenous flora in the small bowel of cats. Normal duodenal flora appeared to be stable, because species of bacteria were re-established by 9 months after cessation of metronidazole. Bacterial flora appeared to have an impact on nutrients, because albumin and cobalamin increased during antibiotic administration and returned to preadministration concentrations after cessation of the antimicrobial.

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Section: Discussionmentioning

confidence: 99%

Effects of oral administration of metronidazole on small intestinal bacteria and nutrients of cats

Johnston

Lamport²,

Ballèvre³

et al. 2000

ajvr

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show abstract

“…[ 10 ] In diabetic patients with bacterial over-growth, protein mal-absorption is the result of several factors: The abundantly present bacteria compete with the host for proteins, amino acid absorption may be impaired as a result of mucosal damage, and the levels of proteolytic enzymes may be decreased. [ 12 13 30 ] The above pathologic processes would result in increased fecal proteins, but this was not the case in this study. It is, therefore, likely that other pathophysiological events could have contributed to this deviant occurrence.…”

Section: Discussionmentioning

confidence: 63%

“…[ 11 ] In diabetic patients with bacterial over-growth, protein mal-absorption is the result of several factors: The abundantly present bacteria compete with the host for protein; amino acid absorption may be impaired as a result of mucosal damage, and the levels of proteolytic enzymes may be decreased. [ 12 13 ]…”

Section: Introductionmentioning

confidence: 99%

Improvement in nutrient handling in STZ induced diabetic rats treated with Ocimum gratissimum

Okon

Davies

Olubobokun

2015

Int J App Basic Med Res

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Objective:Alteration in digestive and absorptive enzymatic activities has been reported in diabetes mellitus (DM), but not with Ocimum gratissimum (OG) treatment. This study was, therefore, designed to indirectly assess the effect of DM and treatment with OG on nutrient digestion and absorption, through estimation of their fecal excretion.Materials and Methods:Animals were randomly assigned into three groups of six per group for control, DM and diabetic mellitus treated (DMT). Diabetes was induced by single intraperitoneal injection of 65 mg/kg streptozotocin in the test groups. OG was administered to the DMT group at dose of 1500 mg/kg once daily for 28 days. Fecal glucose, protein and cholesterol were determined.Results:Fecal glucose was significantly (P < 0.001) lower in the DM group compared to the control and DMT groups, with the DMT groups significantly (P < 0.001) lower than the control. Fecal protein was significantly (P < 0.001) lower in the DM group than the control whereas it was significantly lower in the DMT groups than the DM. Fecal cholesterol was significantly (P < 0.001) higher in the DM than the DMT and control groups with DMT significantly (P < 0.01) higher than the control.Conclusion:This result indicates the propensity of OG to reverse impairment of nutrient digestion and absorption in DM.

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“…Although asymptomatic cases, mostly among the elderly [2], have been described, the condition is generally accompanied by malabsorption and the consequent clinical syndrome is characterized by major symptoms, such as diarrhea, steatorrhea and weight loss, together with abdominal pain, bloating and flatulence. Therefore, an impairment of the nutritional status is frequently present and several nutritional defects have been described [3][4][5][6][7][8][9].…”

Section: Clinical and Pathophysiological Aspectsmentioning

confidence: 99%

Treatment of Small Intestine Bacterial Overgrowth and Related Symptoms by Rifaximin

2005

Chemotherapy

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The treatment of small intestine bacterial overgrowth should address different aims: the removal of the predisposing condition, guarantee of adequate nutritional support to reintegrate both caloric and vitamin requirements and, obviously, suppression of the contaminating bacterial flora, which represents the major goal. The polymicrobic nature of contaminating flora suggests the administration of wide-spectrum antibiotics, but until now there has been no conclusive information on the most effective therapeutic approach. In this paper, the efficacy of the different therapeutic approaches used is reviewed.

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Enterokinase in Contaminated Small-Bowel Syndrome

Cited by 24 publications

References 6 publications

Effects of oral administration of metronidazole on small intestinal bacteria and nutrients of cats

Effects of oral administration of metronidazole on small intestinal bacteria and nutrients of cats

Improvement in nutrient handling in STZ induced diabetic rats treated with Ocimum gratissimum

Treatment of Small Intestine Bacterial Overgrowth and Related Symptoms by Rifaximin

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