Enteropathogenic<i>Klebsiella pneumoniae</i>HIV-Infected Adults, Africa

Thi, Phuong Le; Yassibanda, S.; Aidara, A.; Bouguénec, Chantal Le; Germani, Y

doi:10.3201/eid0901.020138

Cited by 17 publications

(10 citation statements)

References 6 publications

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“…In contrast, the gram positive organism, Streptococcus pneumonia, binds carbohydrates containing the linkages Galβ1-3GalNAc and Galβ1-4GluNAc [5,25,26]. The observation that all of these organisms adhere to HEp-2 cells suggests the presence of a diverse array of carbohydrates receptors to which their adhesins are able to bind [20,[26][27][28][29]. This is also supported by the plant lectin binding experiments reported here.…”

Section: Discussionsupporting

confidence: 73%

Inhibition of lectin adherence to tissue culture cells by prebiotic carbohydrates

Maldonado¹,

Fangman²,

Pinto³

et al. 2013

ABB

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Prebiotic carbohydrates, in addition to their ability to influence the colonic microbiota, are also able to inhibit attachment of pathogenic bacteria to epithelial cells. This effect is mediated via their structural similarity to the carbohydrate ligands, located on the mucosal cell surface to which bacterial lectins attach. However, the mechanism for this inhibition is not well understood. The goal of this research was to measure the effect of two prebiotic carbohydrates, galactooligosaccharide and polydextrose, on the binding kinetics of plant lectins, having known ligand specificity, to tissue culture cells. To measure adherence, competetion experiments were conducted with HEp-2 cells exposed to nine fluorescent-labeled lectins and either the cognate ligand or a prebiotic. Fluorescence microscopy and image analysis were used to quantify adherence. Lectins that were able to bind to target cells were significantly inhibited in the presence of the cognate ligands. When prebiotics were added, inhibittion of lectin binding was observed, depending on the structural similarity between the prebiotic and the cognate ligands. In general, PDX did not inhibit lectin attachment, whereas GOS significantly inhibited most lectins. This research suggests that receptor sites located on the surface of epithelial HEp-2 cells are structurally similar to GOS.

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Section: Discussionsupporting

confidence: 73%

Inhibition of lectin adherence to tissue culture cells by prebiotic carbohydrates

Maldonado¹,

Fangman²,

Pinto³

et al. 2013

ABB

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“…A study of Bacciu et al [2] indicated that an intergeneric transfer of virulence genes (involving the astA gene) via an insertion sequence (IS1414, encoding a transposase (tnpA) and astA in Salmonella) from E. coli together with studies reporting the presence of astA in bacterial genera besides E. coli, like Salmonella Agona [32] and Klebsiella pneumoniae [29] clearly indicate that horizontal transfer of virulence factors, including the astA gene, between bacterial genera occurs in nature and can account for the considerable distribution of the EAST1 gene in E. coli besides EAEC. Yet, there is no evidence of EAST1-dependent fluid secretion in animal studies or of an association of EAST1 with epidemic strains of E. coli with high diarrheagenic potential [2].…”

Section: Discussionmentioning

confidence: 99%

Presence of Escherichia coli carrying the EAST1 toxin gene in farm animals

Veilleux

Dubreuil

2006

Vet. Res.

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-Enteroaggregative Escherichia coli (EAEC) heat-stable toxin 1 (EAST1) is a small toxin of proteic nature. The reference strain producing this toxin was originally detected in the stools of a diarrheic Chilean child. Today, we know that EAST1 is not solely associated with EAEC but also with many other diarrheic E. coli families. Some studies have established the role of EAST1 in human outbreaks of diarrhea. In addition, isolates from farm animals were shown, more recently, to carry the astA gene coding for EAST1. However, the relation between the presence of EAST1 and disease is not conclusive. In this article, the current state of the knowledge on the presence and probable role of EAST1 in farm animal diseases is reviewed and discussed.

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“…They were typical lobar pneumonia (Friedlander pneumonia), acute bronchopneumonia with subclinical aspiration, and chronic K. pneumonia with typical cavitary lung abscesses. These nonmotile bacteria also can cause ventilator-associated pneumonia (Pawar et al, 2003), bacteremia (Yinnon, Butnaru, Raveh, Jerassy, & Rudensky, 1996), septicaemia (Akindele & Rotilu, 1997;Lopes, Rodrigues, & Morais, 2005;Yang, Lauderdale, & Lo, 2004), urinary tract infections (Lopes et al, 2005;Stratton, 2001;Yang et al, 2004), chronic pulmonary disease (Sinha, Panjabi, Varma, Vijayan, & Shah, 2003), soft tissue infections (Lopes et al, 2005;Yang et al, 2004) and diarrhea (Thi, Yassibanda, Aidara, Bouguenec, & Germani, 2003). Yao, Hung, Su, and Chiu (2001) reported a case of beta-thalassaemia major complicated with K. pneumoniae endogenous endophthalmitis in child.…”

Section: Introductionmentioning

confidence: 96%

Incidence of Klebsiella pneumonia in street foods sold in Malaysia and their characterization by antibiotic resistance, plasmid profiling, and RAPD–PCR analysis

Haryani

Noorzaleha²,

Fatimah

et al. 2007

Food Control

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A total of 78 samples of street foods from different states in Malaysia were examined for the presence of Klebsiella pneumonia. K. pneumonia contamination was recorded in 32% of the samples examined. The frequency of the K. pneumonia isolates containing plasmids was shown to be 48%. Susceptibility testing showed that all isolates were highly resistant to ampicillin (100%), erythromycin (100%), rifampicin (100%), streptomycin (96%) and sulfamethoxazole (80%), but susceptible to chloramphenicol. RAPD proved to be the most effective technique in discriminating the K. pneumonia isolates since dendrogram constructed using the combination of 4 primers could differentiate 25 isolates of K. pneumonia to 25 strains. This is the first report that revealed the occurrence of K. pneumonia in street foods sold in Malaysia.

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EnteropathogenicKlebsiella pneumoniaeHIV-Infected Adults, Africa

Cited by 17 publications

References 6 publications

Inhibition of lectin adherence to tissue culture cells by prebiotic carbohydrates

Inhibition of lectin adherence to tissue culture cells by prebiotic carbohydrates

Presence of Escherichia coli carrying the EAST1 toxin gene in farm animals

Incidence of Klebsiella pneumonia in street foods sold in Malaysia and their characterization by antibiotic resistance, plasmid profiling, and RAPD–PCR analysis

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