Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children

Park, Kwisung; Lee, BaeckHee; Baek, KyoungAh; Cheon, Doo‐Sung; Yeo, Sang-Gu; Park, JoonSoo; Soh, Jaewan; Cheon, HaeKyung; Yoon, Kyungah; Choi, Young–Jin

doi:10.1186/1743-422x-9-205

Cited by 41 publications

(35 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As reported in a previous study, herpangina is associated with different strains of enteroviruses, such as CAV2 in Taipei 2008 [48], CAV5 in Korea 2009 [49], CAV6 and CAV10 in France 2010 [45]. In addition, in Japan during 2000–2005, there have been reports of enterovirus infections caused by CAV2, CAV4, CAV6, CAV8 and CAV10 [10].…”

Section: Discussionmentioning

confidence: 83%

Prevalence and Characterization of Enterovirus Infections among Pediatric Patients with Hand Foot Mouth Disease, Herpangina and Influenza Like Illness in Thailand, 2012

et al. 2014

View full text Add to dashboard Cite

Hand, foot, and mouth disease (HFMD) and herpangina are common infectious diseases caused by several genotypes of human enterovirus species A and frequently occurring in young children. This study was aimed at analyzing enteroviruses from patients with these diseases in Thailand in 2012. Detection and genotype determination of enteroviruses were accomplished by reverse transcription-polymerase chain reaction and sequencing of the VP1 region. Enterovirus-positive samples were differentiated into 17 genotypes (coxsackievirus A4 (CAV4), A5, A6, A8, A9, A10, A12, A16, A21, B1, B2, B4, B5, echovirus 7, 16, 25 and Enterovirus 71). The result showed CAV6 (33.5%), followed by CAV16 (9.4%) and EV71 (8.8%) as the most frequent genotypes in HFMD, CAV8 (19.3%) in herpangina and CAV6 (1.5%) in influenza like illness. Enterovirus infections were most prevalent during July with 34.4% in HFMD, 39.8% in herpangina and 1.6% in ILI. The higher enterovirus infection associated with HFMD and herpangina occurred in infants over one year-old. This represents the first report describing the circulation of multiple enteroviruses in Thailand.

show abstract

Section: Discussionmentioning

confidence: 83%

Prevalence and Characterization of Enterovirus Infections among Pediatric Patients with Hand Foot Mouth Disease, Herpangina and Influenza Like Illness in Thailand, 2012

et al. 2014

View full text Add to dashboard Cite

show abstract

“…EV-A71 and CV-A16 were responsible for 90.2% and 8.7% of fatal outcomes, respectively. 17,24,29,31,40,41,44,47,49,58,67 Although usually mild, CV-A16 infection may lead to neural and muscle cells apoptosis 118 and has occasionally been the cause of rhombencephalitis, brain stem encephalitis and acute flaccid paralysis, fatal pneumonitis and fulminant myocarditis with intractable shock. 8 Since 2004, the incidence of CV-A6-and CV-A10-associated HFMD epidemics has markedly increased worldwide [ Table 1].…”

Section: Enteroviruses Cell and Tissue Tropismmentioning

confidence: 99%

Is a multivalent hand, foot, and mouth disease vaccine feasible?

Klein¹,

Chong

2015

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Keywords: bivalent and multivalent vaccines, coxsackievirus A16, coxsackieviruses B3 and B5, echovirus 30, epidemiology, enterovirus A (EV-A), enterovirus A71, hand, foot and mouth diseases, inactivated whole virion vaccines, monovalent, EV-A71 vaccine Enterovirus A infections are the primary cause of hand, foot and mouth disease (HFMD) in infants and young children. Although enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) are the predominant causes of HFMD epidemics worldwide, EV-A71 has emerged as a major neurovirulent virus responsible for severe neurological complications and fatal outcomes. HFMD is a serious health threat and economic burden across the Asia-Pacific region. Inactivated EV-A71 vaccines have elicited protection against EV-A71 but not against CV-A16 infections in large efficacy trials. The current development of a bivalent inactivated EV-A71/CV-A16 vaccine is the next step toward that of multivalent HFMD vaccines. These vaccines should ultimately include other prevalent pathogenic coxsackieviruses A (CV-A6 and CV-A10), coxsackieviruses B (B3 and B5) and echovirus 30 that often co-circulate during HFMD epidemics and can cause severe HFMD, aseptic meningitis and acute viral myocarditis. The prospect and challenges for the development of such multivalent vaccines are discussed.

show abstract

“…EVs are transmitted mainly from person to person by fecal-oral or oral-oral routes and by contact with upper respiratory secretions, fomites, or fluid from blisters [ 2 , 5 ]. Although most EV infections remain asymptomatic, they are also responsible for a wide range of clinical syndromes, such as aseptic meningitis, encephalitis, myocarditis, acute flaccid paralysis, hand-foot-and-mouth disease, and herpangina [ 2 , 3 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Non-rhinovirus enteroviruses associated with respiratory infections in Peru (2005-2010)

Huaman

Carrión

Ampuero

et al. 2014

Virol J

View full text Add to dashboard Cite

BackgroundEnteroviruses (EVs) are a common cause of respiratory tract infections and are classified into seven species (EVA-D and rhinoviruses [RHVs] A-C) with more than 200 different serotypes. Little is known about the role of non-RHV EVs in respiratory infections in South America. The aim of this study was to describe the epidemiology of non-RHV EVs detected in patients with influenza-like illness enrolled in a passive surveillance network in Peru.MethodsThroat swabs and epidemiological data were collected from participants after obtaining verbal consent. Viral isolation was performed in cell culture and identified by immunofluorescence assay. Serotype identification of EV isolates was performed using commercial monoclonal antibodies. Identification of non-serotypeable isolations was carried out by reverse transcriptase-PCR, followed by sequencing.ResultsBetween 2005 and 2010, 24,239 samples were analyzed, and 9,973 (41.1%) possessed at least one respiratory virus. EVs were found in 175 samples (0.7%). Our results revealed a clear predominance of EVB species, 90.9% (159/175). No EVDs were isolated. The mean and median ages of EV-positive subjects were 9.1 and 4.0 years, respectively, much younger than the population sampled, 17.6 and 12.0 years. Sixteen serotypes were identified, four EVA, 11 EVB, and one EVC species. The most common serotypes were coxsackievirus B1, coxsackievirus B2, coxsackievirus B5, and coxsackievirus B3.ConclusionThis study provides data about the serotypes of EVs circulating in Peru and sets the need for further studies.

show abstract

Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children

Cited by 41 publications

References 31 publications

Prevalence and Characterization of Enterovirus Infections among Pediatric Patients with Hand Foot Mouth Disease, Herpangina and Influenza Like Illness in Thailand, 2012

Prevalence and Characterization of Enterovirus Infections among Pediatric Patients with Hand Foot Mouth Disease, Herpangina and Influenza Like Illness in Thailand, 2012

Is a multivalent hand, foot, and mouth disease vaccine feasible?

Non-rhinovirus enteroviruses associated with respiratory infections in Peru (2005-2010)

Contact Info

Product

Resources

About