Entrapment of 5-fluorouracil into PLGA matrices using supercritical antisolvent processes

Kalantarian, Pardis; Haririan, Ismaeil; Najafabadi, Abdolhossein Rouholamini; Shokrgozar, Mohammad Ali; Vatanara, Alireza

doi:10.1111/j.2042-7158.2010.01249.x

Cited by 14 publications

(7 citation statements)

References 22 publications

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“…Up to now, the SAS process has been widely exploited to produce composite polymer/active compound systems for various biomedical applications. In particular, composite particles were produced to treat inflammations [8,11,46,65,98,99], infections [17,[100][101][102][103][104][105][106], asthma and allergies [22,32,44,93], diabetes [35,107,108], hypertension [34,70], and other diseases [39,94,[109][110][111][112][113]. Different kinds of active principles, both with synthetic and natural origin, have been incorporated into polymeric particles.…”

Section: Sas Coprecipitation Of Active Compounds With Polymeric Carriersmentioning

confidence: 99%

“…Eudragit L100-55 allowed reaching a controlled release of NSAIDs, antibiotics, and bronchodilator drugs from SAS microspheres [44,104]. Until now, the SAS coprecipitation was attempted using other kinds of polymers, such as polyethylene glycol (PEG) [35,106,129,130], poly(lactide-co-glycolide) (PLGA) [36,37,109], ethyl cellulose (EC) [91,[100][101][102]105], HPMC [34,39,42,70,107], and poly(hydroxybutyrate-co-hydroxyvalerate (PHBV) [95,96,[131][132][133][134][135]. However, the use of these carriers must be further investigated, by changing the selected solvents or/and the operating conditions, because the morphology of the polymer/drug precipitated powder is not yet satisfactory.…”

Section: Sas Coprecipitation Of Active Compounds With Polymeric Carriersmentioning

confidence: 99%

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Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Franco

Marco

2020

Processes

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The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of different pathologies and to better the patient’s compliance. In this context, many active compounds have been micronized to enhance their dissolution rate and bioavailability. Aiming for more effective treatments with reduced side effects caused by drug overdose, the SAS polymer/active principle coprecipitation has mainly been proposed to offer an adequate drug release for specific therapy. The demand for new formulations with reduced side effects on the patient’s health is still growing; in this context, the SAS technique is a promising tool to solve existing issues in the biomedical field. This updated review on the use of the SAS process for clinical applications provides useful information about the achievements, the most effective polymeric carriers, and parameters, as well as future perspectives.

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Section: Sas Coprecipitation Of Active Compounds With Polymeric Carriersmentioning

confidence: 99%

Section: Sas Coprecipitation Of Active Compounds With Polymeric Carriersmentioning

confidence: 99%

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Franco

Marco

2020

Processes

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“…Co-polymers of polylactic and polyglycolic acids as microparticles incorporating indomethacin have been produced by a variant of the SAS method, namely, solution-enhanced dispersion by supercritical fluids (SEDS) [115]. This polymeric matrix, incorporating the antitumor agent 5-fluorouracil, was produced by an SAS method from supercritical carbon dioxide too [116]. Low-cross-linked polymethacrylate matrices, produced from 2-(dimethyl-amino)ethyl methacrylate and incorporating ibuprofen, were produced in supercritical carbon dioxide and shown to have high loading of the drug and efficient controlled release [117].…”

Section: Preparation Of Nano-sized Particlesmentioning

confidence: 99%

Some Advances in Supercritical Fluid Extraction for Fuels, Bio-Materials and Purification

Marcus

2019

Processes

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Supercritical fluids are used for the extraction of desired ingredients from natural materials, but also for the removal of undesired and harmful ingredients. In this paper, the pertinent physical and chemical properties of supercritical water, methanol, ethanol, carbon dioxide, and their mixtures are provided. The methodologies used with supercritical fluid extraction are briefly dealt with. Advances in the application of supercritical extraction to fuels, the gaining of antioxidants and other useful items from biomass, the removal of undesired ingredients or contaminants, and the preparation of nanosized particles of drugs are described.

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“…This method has been modified by dissolving the API in a liquid to which a SCF is added as an antisolvent that causes API precipitation of the API [270,271]. Depending on the method of crystallization, SCF technology can be classified into three main processes: gas anti-solvent (GAS) [272], aerosol solvent extraction system (ASES) process and solution-enhanced dispersion by SCFs (SEDS) [270].…”

Section: Principlementioning

confidence: 99%

Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges

Kaialy

Shafiee

2016

Advances in Colloid and Interface Science

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The advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore pharmacokinetic properties similar to those observed in solutions. The present review outlines the recent advances, promises and challenges of the engineering nanosized APIs. The principles, merits, demerits and applications of the current 'bottom-up' and 'top-down' technologies by which the state of the art nanosized APIs can be produced were described. Although the number of research reports on the nanoparticle engineering topic has been growing in the last decade, the challenge is to take numerous research outcomes and convert them into strategies for the development of marketable products.

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Entrapment of 5-fluorouracil into PLGA matrices using supercritical antisolvent processes

Abstract: Application of supercritical processing for co-precipitation of 5-FU and PLGA provided mild and non-aqueous conditions, so the hydrophilic drug incorporated in the polymer had good stability during the process.

Cited by 14 publications

References 22 publications

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Some Advances in Supercritical Fluid Extraction for Fuels, Bio-Materials and Purification

Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges

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