Entrapment of an ACE inhibitory peptide into ferritin nanoparticles coated with sodium deoxycholate: Improved chemical stability and intestinal absorption

Liu, Ying; Zhang, Yuncheng; Chen, Zhi; Huang, Wuyang; Cui, Li; Li, Chunyang; Ma, Kaiyang; Hu, Xindi; Feng, Jia‐Xun

doi:10.1016/j.lwt.2021.111547

Cited by 8 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results were likely to have arisen from the reduced accessibility of the loaded peptides to ACE by the outer vesicles of the liposomes, which function as barriers, whereas chitosan modification made the vesicle structure more stable. Therefore, the release of the loaded peptides was slower, thereby resulting in a lower rate of reactions between the loaded peptides and ACE (Li et al., 2021; Ramezanzade et al., 2021). This suggested that nanoliposomes can reduce the excretion of peptides and therefore can maintain the ACE inhibitory activity of peptides.…”

Section: Resultsmentioning

confidence: 99%

Chitosan‐coated nanoliposomes for the enhanced stability of walnut angiotensin‐converting enzyme (ACE) inhibitory peptide

Cao

Hao

Wang

et al. 2023

Journal of Food Science

View full text Add to dashboard Cite

This study encapsulated walnut angiotensin‐converting enzyme (ACE) inhibitory peptides within nanoliposomes and then modified them with chitosan. The resulting effect of the nanoliposome loading and chitosan coating on physicochemical characteristics, stability, bioactivity, chemical structure, and morphology of the encapsulated peptides was assessed. The resulting particle size and polymer dispersity index revealed that the chitosan‐coated nanoliposomes loaded with walnut ACE inhibitory peptides (WAIP) (CL‐P) exhibited higher physical stability compared with the nanoliposomes loaded with WAIP (L‐P). The encapsulation efficiency (EE) of CL‐P increased from 73.32% to 76.13% after chitosan modification, and the EE of L‐P and CL‐P could be maintained by storage at 4°C. In addition, the antioxidant activity and ACE inhibitory activity of the peptides were effectively protected by L‐P and CL‐P during storage. Fourier transform infrared spectroscopy showed that the nanoliposomes were bound in ionic form with both the peptides and chitosan. Transmission electron micrographs indicated the presence of vesicle‐like carriers with a reservoir‐type structure. This study highlights the potential of nanoliposomes and their modification with chitosan to increase the stability and bioactivity retention of ACE inhibitory peptides. Practical Application Chitosan‐coated nanoliposomes loaded with walnut ACE inhibitory peptides were prepared in this study. Chitosan coating increased nanoliposomes’ encapsulation efficiency and provided higher physical stability. In addition, the bioactivity of the walnut ACE peptides was effectively protected during storage. This study was relevant for improving the storage and transportation used for nanoliposome systems applied in the food and health product industry.

show abstract

Section: Resultsmentioning

confidence: 99%