Entrapment of herbal extracts into biodegradable microcapsules

Bоrodinа, Tatyana N.; Румш, Л. Д.; Kunizhev, S. M.; Sukhorukov, Gleb B.; Vorozhtsov, Georgy N.; Feldman, Baruch; Rusanova, A. V.; Васильева, Т. В.; Strukova, S. M.; Марквичева, Елена

doi:10.1134/s199075080802008x

Cited by 16 publications

(17 citation statements)

References 20 publications

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“…After the complete solution of the carbonate matrix, polyelec trolyte microcapsules were washed with water and stored as a suspension at 4°C. Microcapsules with the architecture [DS/poly(Arg)] 3 were used in the work.…”

Section: Methodsmentioning

confidence: 99%

“…In recent years, a great num ber of papers have been devoted to the delivery of bio active substances into cells by means of polyelectrolyte capsules [1][2][3][4][5]. An encapsulated protein has a number of advantages over a nonencapsulated one; these are the possibility of targeted delivery of biologically active substances, a prolonged exit from microcap sules, and the protection of the protein against destruction and sorption in biological fluids of the organism during the delivery to cells.…”

Section: Introductionmentioning

confidence: 99%

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Delivery of lactoferrin to cells using biodegradable microcapsules

et al. 2016

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The possibility of the effective delivery of lactoferrin to the cells of the innate immune system (neutrophils and monocytes) by means of biodegradable polyelectrolyte microcapsules has been shown. A study of the effect of the structural component of microcapsules, poly L arginine, has shown that the pro duction of reactive oxygen species (ROS) was maximum at a concentration of the polyelectrolyte of 0.5 μg/mL. Increasing the polycation concentration significantly decreased the neutrophil viability and ROS production. The study of neutrophil apoptosis showed that hollow microcapsules containing no lactoferrin accelerated the apoptosis of phagocytes by 15-20%. Encapsulated lactoferrin inhibited the neutrophil apo ptosis by 65-70%, whereas nonencapsulated lactoferrin decreased it by 35%. It was found that encapsulated lactoferrin reduced the production of TNF α by THP 1 promonocytic cells to an approximately the same degree as nonencapsulated lactoferrin.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Delivery of lactoferrin to cells using biodegradable microcapsules

et al. 2016

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“…The in vitro release from microspheres of Lycopene has been determined [4,6,8]. In the USP basket style dissolution test apparatus, an in vitro drug release analysis was conducted.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

“…Phytosomes of phospholipid drugs have been developed [3] . Microcapsules have been prepared by layer-by-layer adsorption of carrageenan and oligochitosan into micro-particles of calcium carbonate in the treatment of gastric ulcers [4] . In view of these advantages of drug distribution, the present study was carried out to integrate Lycopene into mucoadhesive sodium alginate, carbopol 934 and sodium CMC microcapsules and to test their physicochemical parameters.…”

Section: Introductionmentioning

confidence: 99%

Novel drug delivery system of Lycopene: Preparation and in-vitro investigation

D¹,

Panneerselvam²,

Vijayamma³

et al. 2021

ijprls

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Compared to pharmaceutical drugs, herbal medications have known to be more affordable and better for the treatment of many diseases but are less effective and not targeted. Therefore, the use of innovative drug delivery devices to distribute herbal drugs is very helpful in enhancing their release, potency and operation. Lycopene was introduced into the muco-adhesive microspheres. Using sodium alginate, carbopol 934, and sodium CMCC, mucoadhesive microspheres were prepared (carboxy methyl cellulose). The prepared microspheres had been evaluated for its physical and physicochemical parameters, invitro release. The prepared microspheres showed consistent physicochemical parameters, release sustained to 8hrs. Herbal drugs can preferably be delivered using novel drug delivery systems after proper chemical and biological standardization.

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“…Using the model of acetate ulcer in rats, it has been demonstrated that PCE released from the microcapsules accelerates gastric tissue repair. [ 20 ]…”

Section: Herbal Novel Drug Delivery Systemsmentioning

confidence: 99%

Importance of novel drug delivery systems in herbal medicines

2010

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Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. Our country has a vast knowledge base of Ayurveda whose potential is only being realized in the recent years. However, the drug delivery system used for administering the herbal medicine to the patient is traditional and out-of-date, resulting in reduced efficacy of the drug. If the novel drug delivery technology is applied in herbal medicine, it may help in increasing the efficacy and reducing the side effects of various herbal compounds and herbs. This is the basic idea behind incorporating novel method of drug delivery in herbal medicines. Thus it is important to integrate novel drug delivery system and Indian Ayurvedic medicines to combat more serious diseases. For a long time herbal medicines were not considered for development as novel formulations owing to lack of scientific justification and processing difficulties, such as standardization, extraction and identification of individual drug components in complex polyherbal systems. However, modern phytopharmaceutical research can solve the scientific needs (such as determination of pharmacokinetics, mechanism of action, site of action, accurate dose required etc.) of herbal medicines to be incorporated in novel drug delivery system, such as nanoparticles, microemulsions, matrix systems, solid dispersions, liposomes, solid lipid nanoparticles and so on. This article summarizes various drug delivery technologies, which can be used for herbal actives together with some examples.

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Entrapment of herbal extracts into biodegradable microcapsules

Cited by 16 publications

References 20 publications

Delivery of lactoferrin to cells using biodegradable microcapsules

Delivery of lactoferrin to cells using biodegradable microcapsules

Novel drug delivery system of Lycopene: Preparation and in-vitro investigation

Importance of novel drug delivery systems in herbal medicines

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