The Benoistii Crossandra L. A widely distributed plant in India and Africa belongs to the Acanthaceae family. The forests of India have traditionally been used by several tribal people. This plant is home to many forests in India and is rich in Southern India. In this study, methanol and ethanol leaf extracts were tested for antiulcer activity following the folklore reports of antimicrobial activity. Methanolic and aqueous extracts were studied and proven to be equally effective in prevention and cure of ulcers for synthetic medicines. The CBME and CBEE inhibits were at 400 mg/kg higher than normal and the lower doses of 200 mg/kg still appeared to be the same operation as the standard one. The higher dose of the extracts was supposed to lead to greater activity. With the maximal dose of 2000mg/kg, the UD50 is raised, and the above limits contribute to an even greater dose than the one seen in the process. Given the side effects of prescription medications, it is strongly recommended to use natural medicines for the ulcer. Much phytochemical study has been carried out on the plant and the same number of feedings has so far been isolated. It demands that the latest medicine provision be implemented in order to include plant extracts to cure all diseases.

Compared to pharmaceutical drugs, herbal medications have known to be more affordable and better for the treatment of many diseases but are less effective and not targeted. Therefore, the use of innovative drug delivery devices to distribute herbal drugs is very helpful in enhancing their release, potency and operation. Lycopene was introduced into the muco-adhesive microspheres. Using sodium alginate, carbopol 934, and sodium CMCC, mucoadhesive microspheres were prepared (carboxy methyl cellulose). The prepared microspheres had been evaluated for its physical and physicochemical parameters, invitro release. The prepared microspheres showed consistent physicochemical parameters, release sustained to 8hrs. Herbal drugs can preferably be delivered using novel drug delivery systems after proper chemical and biological standardization.

Various approaches have been used to retain the dosage form in the stomach as a way ofincreasing the gastric residence time (GRT), including floatation systems; high-density systems; mucoadhesive systems; magnetic systems; unfoldable, extendible, or swellable systems; andsuperporous hydrogel systems. The aim of this study was to prepare and evaluate floatingmicrospheres of cefdinir for the prolongation of gastric residence time. Themicrospheres were prepared byCapillary Extrusion method.A full factorial design was applied to optimize the formulation. The optimum batch of microsphere exhibited smooth surfaces with good flow and packing properties, prolonged sustained drug release, remained buoyant for more than 12 hrs, high entrapment efficiency upto68%.Scanning electron microscopy confirmed the hollown structure with particle size in the order of190 μm. The studies revealed that increase in concentration of gum Karaya increased the drug release from the floating microspheres.

The purpose of this work was to incorporate superporus hydrogels for cefditoren pivoxil by using polymer like poly acrylic acid aqua cc polymer and composite agent like cross linked sodium carboxy methyl cellulose in the presence of N,N-methylene-bis-Acrylamide as crosslinking agent. Pluronic F-127 as a stabilizer and ammonium per sulfate and tetramethylene diamine as a initiator pair. Poly acrylic acid aqua cc polymer-cross linked sodium carboxy methyl cellulose superporus hydrogels of cefditoren pivoxil were incorporate by gas blowing technique. The reaction  of pH on the swelling ratio was decisive. Swelling reversibility research was also achieve. Fourier transform infrared spectroscopy analysis and scanning electron microscopy studies were assume to indicate the drug loaded superporous hydrogels, while dissolution studies were achieve to assess release characteristics. Swelling was hugely depending on the term of crosslinking and the quantity of the polymer existing in formulation. The huge amount of cross-linking agent reduced the swelling ratio. The superporous hydrogels were hugely perceptive to pH of swelling medium, and exhibit reversible swelling and de-swelling behavior during still keep their mechanical stability. Apparent density was reliant on the amount of the superporous hydrogels and reduced with developing crosslink density. Degradation kinetics reveals that poly acrylic acid aqua cc polymer superporous hydrogels had good water holding potential. Drug release was similar to quantity of cross-linking agent. The studies report that poly acrylic acid aqua cc polymer superporous hydrogels can be used as a Gastroretentive drug delivery system in view of their swelling characteristics in acidic pH.

Hyperlipidemia is a common condition among today's generation. Only a few medicines are available for treatment, but they pose a risk if used for an extended period of time. As a result, the objective of this study is to find a potential HMG-CoA reductase inhibitor in a natural traditional plant, Schleichera oleosa. The extract was prepared through the cold maceration of the tree's bark with methanol. The preliminary phytochemical assessment was carried out in accordance with the standard test. The HMG-CoA reductase inhibition test kit was used as an in-vitro investigation to investigate the inhibitory potential of phytoconstituents at 2, 10, 20, 40, 60, 80, and 100 µg/ml. For 600 seconds, spectrophotometric scans (340 nm) were performed at 30 second intervals. The in-silico ligand-protein docking approach was used to determine the binding potential of phytoconstituents to a complex of the catalytic part of human HMG-CoA reductase (1HW8). The presence of triterpenes, phenols, tannins, glycosides, carbohydrates, and sterols was found, but flavonoids, alkaloids, and saponins were absent. The phytoconstituents were shown to be effective in the inhibition experiment, with 63.14 ± 0.34 % inhibition at 100 µg/ml, and the extract's IC50 was 54.87 µg/ml.