The purpose of the study is in two fold. First, the study examines the impact of language, history, and culture in Anglophone and Francophone countries on the rate of unemployment and economic growth. Second, the study explores the extent to which sustainable entrepreneurship influences the rate of unemployment, and economic growth in Anglophone and Francophone (A&F) countries. The study employed a descriptive and quantitative research design where a longitudinal data were sourced from the World Development Indicators and World Bank Entrepreneurship databases on 12 and 9 Francophone and Anglophone countries respectively. The random effect and the generalized method of moments (GMM) regression models were employed to attain the objectives of the study. The findings of the study revealed that there is a significant negative effect of sustainable entrepreneurship on unemployment; sustainable entrepreneurship has a positive significant effect on economic growth; and also, history and culture were found to have a significant impact on unemployment reduction and economic growth. However, language was found to have an insignificant influence between A&F countries suggesting that the ability of sustainable entrepreneurship to minimize the rate of unemployment and boost economic growth is generic irrespective of linguistic factors.