2011
DOI: 10.1021/jz2013566
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Entropy Balance in the Intercalation Process of an Anti-Cancer Drug Daunomycin

Abstract: I ntercalation 1 is one of the important biophysical processes by which anticancer drugs (such as daunomycin) interact with DNA causing subsequent death of cancerous cells. The enormous therapeutic significance of daunomycin 2 (DM) and related anticancer drugs 3 invoked exhaustive studies on thermodynamic analysis of the intercalation 4À6 and other drugÀDNA binding processes 7,8 portraying a general enthalpy/entropy balance. 9À11 Chaires surmised an interesting aspect of thermodynamic features of drugÀDNA bind… Show more

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Cited by 36 publications
(35 citation statements)
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“…93,94 This effect however is dependent upon the "depth of insertion". [98][99][100] Common organic intercalators include phenanthrolines, 101 phenanthridines, 102 acridines, 102 anthraquinones, 103 anthracenes, 104 and ellipticines. [98][99][100] Common organic intercalators include phenanthrolines, 101 phenanthridines, 102 acridines, 102 anthraquinones, 103 anthracenes, 104 and ellipticines.…”
Section: Intercalationmentioning
confidence: 99%
“…93,94 This effect however is dependent upon the "depth of insertion". [98][99][100] Common organic intercalators include phenanthrolines, 101 phenanthridines, 102 acridines, 102 anthraquinones, 103 anthracenes, 104 and ellipticines. [98][99][100] Common organic intercalators include phenanthrolines, 101 phenanthridines, 102 acridines, 102 anthraquinones, 103 anthracenes, 104 and ellipticines.…”
Section: Intercalationmentioning
confidence: 99%
“…The pRDF method has been used for calculating solvation entropy changes during the intercalation process of an anticancer drug. 20 …”
Section: Introductionmentioning
confidence: 99%
“…A negative change in entropy can be attributed to the favorable electrostatic interactions between ligands and RNA [55,57]. Note that the resultant entropy change appeared during flavins-aptamer binding is the combined effect of drug entropy change, RNA entropy change as well as entropy change of water during binding process [58]. It is obvious that drug entropy will decrease while binds to aptamer, and the flexibility of RNA decreases during the interaction with drug or protein [59].…”
Section: Isothermal Titration Calorimetry (Itc): a Thermodynamic Glimpsementioning
confidence: 99%
“…It is obvious that drug entropy will decrease while binds to aptamer, and the flexibility of RNA decreases during the interaction with drug or protein [59]. On the other hand, water entropy generally increases when a drug binds to DNA/RNA, as water molecules are coming out from the surrounding of ligand binding location in RNA [58]. Therefore, the negative entropy is originated by the cancellation of positive entropy change for water by the negative entropy change of RNA as well as flavins.…”
Section: Isothermal Titration Calorimetry (Itc): a Thermodynamic Glimpsementioning
confidence: 99%